Inflammatory signaling differentially changes chromatin accessibility and gene expression of the PD- associated kinase LRRK2 between human and mice [0.03%]
炎症信号改变PD相关激酶LRRK2的染色质可及性和基因表达在人类和小鼠中的差异性研究
Alexandra Beilina,Jae-Hyeon Park,Natalie Landeck et al.
Alexandra Beilina et al.
Chunli Sun,Qianjin Liu
Chunli Sun
Altered trafficking of Kv1-Kvβ2 leads to neuronal hyperexcitability and memory deficits in amyloid-β pathology [0.03%]
淀粉样蛋白病理改变Kv1-Kvβ2转运导致神经元过度兴奋和记忆缺陷
Young-Sin Cho,Seo-Hyun Kim,Shin-Hyeon Ryu et al.
Young-Sin Cho et al.
Systems biology of Alzheimer's Disease: a scoping review of key pathways and mechanisms [0.03%]
阿尔茨海默病系统生物学：关键通路及机制的综述研究
Paula J Bice,Kwangsik Nho,Nilüfer Ertekin-Taner et al.
Paula J Bice et al.
Shirel Argueti-Ostrovsky,Su Min Lim,Olubankole A Arogundade et al.
Shirel Argueti-Ostrovsky et al.
The functional role of glial cells in the pathologic brain as reviewed by Alois Alzheimer in 1910 [0.03%]
阿尔兹海默1910年对病态大脑中胶质细胞的功能作用的评述
Helmut Kettenmann,Hans Lassmann,Bilge Ugursu et al.
Helmut Kettenmann et al.
Targeting tau in Alzheimer's Disease: rationale, approach and challenges [0.03%]
阿尔茨海默病的tau治疗：理由、方法及挑战
Aram Aslanyan,Martha S Foiani,Tatiana A Giovannucci et al.
Aram Aslanyan et al.
Lipid alterations in hereditary peripheral neuropathies: common mechanisms in disease heterogeneity? [0.03%]
遗传性周围神经病变中的脂质改变：异质性疾病中的共同机制？
Koen Kuipers,Sam Vanherle,Kirsten Poelmans et al.
Koen Kuipers et al.
Two lysosomal genes ATP13A2 and GBA1 interact to drive neurodegeneration [0.03%]
与溶酶体相关的两个基因ATP13A2和GBA1的互作促进神经退行性病变
Mingxue Gu,Jinghan Zhao,Mingxi Deng et al.
Mingxue Gu et al.
Multi-omics insights into GBA1-associated Parkinson's disease: interplay of genomics, transcriptomics, proteomics, and lipidomics [0.03%]
GBA1相关帕金森病的多组学见解：基因组、转录组、蛋白质组和脂质组的相互作用
Yang Ni,Huaibin Cai,Yaping Shao et al.
Yang Ni et al.
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide. The pathogenesis of PD is driven by multifactorial mechanisms involving a complex interplay among environmental exposures, genetic susceptibility, ...