Mitochondria transfer in neurological disorders: the key role of neuroglia [0.03%]
线粒体转移在神经性疾病中的作用：神经胶质细胞的关键作用
Jie Jiao,Hui Chen,Alexei Verkhratsky et al.
Jie Jiao et al.
Mitochondria transfer has emerged as a distinctive mechanism for intercellular communication and neuronal homeostasis. Neurones, owing to their unique bioenergetic demands, are particularly vulnerable to mitochondrial dysfunction, a shared ...
Tauseef R Butt
Tauseef R Butt
Pharmacological restoration of impaired autophagy in retinal ganglion cells prevents abnormal mitochondrial accumulation and glaucomatous neurodegeneration [0.03%]
药理学恢复视网膜神经节细胞的受损自噬可预防异常线粒体积累和青光眼神经退行性病变
Prabhavathi Maddineni,Balasankara Reddy Kaipa,Bindu Kodati et al.
Prabhavathi Maddineni et al.
Background: Progressive loss of retinal ganglion cells (RGCs) and degeneration of optic nerve (ON) axons are the key pathological hallmarks of glaucoma, the leading cause of irreversible blindness. Elevated intraocular pr...
Irika R Sinha,Abigail L Atkinson,Katherine E Irwin et al.
Irika R Sinha et al.
TDP-43 is a ubiquitously expressed, primarily nuclear DNA/RNA-binding protein implicated in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer's disease (AD). In this revie...
LRRK2 and GBA1 in Lewy body diseases: neuropathological subtypes at opposite ends of a spectrum? [0.03%]
LRRK2和GBA1在路易体疾病中的作用：神经病理亚型处于连续谱的两端？
Vedika Jha,Lorraine V Kalia
Vedika Jha
Plasma proteomic signatures of preclinical Alzheimer's disease in clinically unimpaired older adults [0.03%]
无认知障碍老年人中阿尔茨海默病临床前期的血浆蛋白质组标志物
Alexandra N Trelle,Karly A Cody,Tran T Nguyen et al.
Alexandra N Trelle et al.
Obesity-driven phosphatidylethanolamine dysregulation impairs neuroimmune crosstalk and accelerates Alzheimer's pathogenesis [0.03%]
肥胖诱发的磷脂酰乙醇胺失调损害神经免疫相互作用并加速阿尔茨海默病发病机制
Li Yang,Jianting Sheng,Shaohua Qi et al.
Li Yang et al.
Regional diffusion imaging measures to disentangle SVD-related hypertensive arteriopathy versus cerebral amyloid angiopathy [0.03%]
区域弥散成像措施可区分与高血压血管病有关的SVD和脑淀粉样血管病
Sheelakumari Raghavan,Scott A Przybelski,Robel K Gebre et al.
Sheelakumari Raghavan et al.
Andy P Tsai,Amara K Martin,Andrew Mi et al.
Andy P Tsai et al.
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and pathological hallmarks, including amyloid plaques, tau tangles, microgliosis, and chronic neuroinflammation. Over the past decade, ...
Molecular characterization of humanized APOE mouse models reveals source and genotype dependent differences [0.03%]
人源化APOE小鼠模型的分子特征表明来源和基因型依赖性差异
Na Wang,Gefei Yu,Zhen Wang et al.
Na Wang et al.