Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease [0.03%]
表观遗传调控与成体神经干细胞及阿尔茨海默病的关系
Carlos P Fitzsimons,Emma van Bodegraven,Marijn Schouten et al.
Carlos P Fitzsimons et al.
Experimental evidence has demonstrated that several aspects of adult neural stem cells (NSCs), including their quiescence, proliferation, fate specification and differentiation, are regulated by epigenetic mechanisms. These control the expr...
Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice [0.03%]
通过预防肠梗阻揭示突变TDP-43（A315T）小鼠进行性神经退行性病变
Sarah Herdewyn,Carla Cirillo,Ludo Van Den Bosch et al.
Sarah Herdewyn et al.
Background: Intraneuronal inclusions of TAR DNA-binding protein 43 (TDP-43) have been found in the majority of Amyotrophic Lateral Sclerosis (ALS) patients. Mutations in the gene encoding TDP-43 cause familial ALS. Transg...
Vacuolar protein sorting 35 (Vps35) rescues locomotor deficits and shortened lifespan in Drosophila expressing a Parkinson's disease mutant of Leucine-Rich Repeat Kinase 2 (LRRK2) [0.03%]
溶酶体降解途径关键蛋白Vps35能够缓解人类帕金森病致病基因LRKK2突变造成的果蝇行为异常和寿命缩短缺陷
Radek Linhart,Sarah Anne Wong,Jieyun Cao et al.
Radek Linhart et al.
Background: Parkinson's disease (PD) is the most common movement neurodegenerative movement disorder. An incomplete understanding of the molecular pathways involved in its pathogenesis impedes the development of effective...
Identification of longitudinally dynamic biomarkers in Alzheimer's disease cerebrospinal fluid by targeted proteomics [0.03%]
定量蛋白质组学鉴定阿尔茨海默病脑脊液纵向动态生物标志物
Kristin R Wildsmith,Stephen P Schauer,Ashley M Smith et al.
Kristin R Wildsmith et al.
Background: Alzheimer's disease (AD) is the leading cause of dementia affecting greater than 26 million people worldwide. Although cerebrospinal fluid (CSF) levels of Aβ42, tau, and p-tau181 are well established as diagn...
Ryanodine receptors: physiological function and deregulation in Alzheimer disease [0.03%]
ryanodine受体的生理功能及其在阿尔茨海默病中失调的作用
Dolores Del Prete,Frédéric Checler,Mounia Chami
Dolores Del Prete
Perturbed Endoplasmic Reticulum (ER) calcium (Ca2+) homeostasis emerges as a central player in Alzheimer disease (AD). Accordingly, different studies have reported alterations of the expression and the function of Ryanodine Receptors (RyR) ...
Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2 [0.03%]
TREM2杂合APPPS1-21小鼠中Aβ斑块诱导的小胶质细胞反应的改变
Jason D Ulrich,Mary Beth Finn,Yaming Wang et al.
Jason D Ulrich et al.
Background: Recent genome-wide association studies linked variants in TREM2 to a strong increase in the odds of developing Alzheimer's disease. The mechanism by which TREM2 influences the susceptibility to Alzheimer's dis...
Ekaterina Poguzhelskaya,Dmitry Artamonov,Anastasia Bolshakova et al.
Ekaterina Poguzhelskaya et al.
Background: Imaging methods are used widely to understand structure of brain and other biological objects. However, sample penetration by light microscopy is limited due to light scattering by the tissue. A number of meth...
Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodies [0.03%]
积累α-突触核蛋白片段的海马神经元细胞通过mGluR5对Aβ寡聚体毒性更易感—阿尔茨海默病伴路易小体痴呆的意义
Cassia R Overk,Anna Cartier,Gideon Shaked et al.
Cassia R Overk et al.
Background: In dementia with Lewy bodies (DLB) abnormal interactions between α-synuclein (α-syn) and beta amyloid (Aβ) result in selective degeneration of neurons in the neocortex, limbic system and striatum. However, ...
The Parkinsonian mimetic, 6-OHDA, impairs axonal transport in dopaminergic axons [0.03%]
6-羟多巴胺（帕金森病拟态）损害多巴胺能轴突运输
Xi Lu,Jeong Sook Kim-Han,Steve Harmon et al.
Xi Lu et al.
6-hydroxydopamine (6-OHDA) is one of the most commonly used toxins for modeling degeneration of dopaminergic (DA) neurons in Parkinson's disease. 6-OHDA also causes axonal degeneration, a process that appears to precede the death of DA neur...
Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease [0.03%]
老年增多的线粒体DNA突变促进APP / LD转基因小鼠阿尔茨海默病模型中淀粉样蛋白积累和脑萎缩发生
Lokesh Kukreja,Gregory C Kujoth,Tomas A Prolla et al.
Lokesh Kukreja et al.
Background: The role of mitochondrial dysfunction has long been implicated in age-related brain pathology, including Alzheimer's disease (AD). However, the mechanism by which mitochondrial dysfunction may cause neurodegen...