Skin biopsy: an emerging tool for the diagnosis of protein misfolding diseases of the central nervous system [0.03%]
皮肤活检：中枢神经系统蛋白错误折叠疾病诊断的新兴工具
Wei Zhu,Hao-Lun Sun,Yan-Jiang Wang et al.
Wei Zhu et al.
Alpha-synuclein seeding amplification assays in Lewy body dementia: a brief review [0.03%]
路易体痴呆中α-突触核蛋白种子放大实验的简要综述
Maria Bregendahl,Zeynep Bengisu Kaya,Wolfgang Singer et al.
Maria Bregendahl et al.
Lewy body dementia (LBD), which includes dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), is characterized by cognitive decline, sleep disturbances, motor dysfunction, and other debilitating clinical symptoms. Neuropa...
Current strategies in the management of dementia with lewy bodies and future directions based on disease pathophysiology [0.03%]
基于疾病病理生理的 Lewy 体痴呆症的当前管理策略及未来方向
Daniel Erskine,John-Paul Taylor
Daniel Erskine
Dementia with Lewy bodies (DLB) is thought to be the second most common form of dementia after Alzheimer’s disease, and is characterised by a combination of cognitive, neuropsychiatric and motor symptoms. The present review seeks to discus...
Mechanisms of interventions targeting modifiable factors for dementia risk reduction [0.03%]
针对可改变的危险因素减缓痴呆风险的干预机制
Anna Matton,Ruth Stephen,Makrina Daniilidou et al.
Anna Matton et al.
The global prevalence of dementia is increasing. With no widely available and accessible treatments to halt or reverse the progression of dementia, exploring preventative strategies is critical. Lifestyle-based interventions show promise in...
The PKCι-β-arrestin2 axis disrupts SORLA retrograde trafficking, driving its degradation and amyloid pathology in Alzheimer's disease [0.03%]
PKCι-β-arrestin2信号轴干扰SORLA逆向运输促使其降解并驱动阿尔茨海默病淀粉样病理损害
Hasibur Rehman,Shun Yan,Shalini Saggu et al.
Hasibur Rehman et al.
Background: Variants of SORL1 have been associated with both late and early onset of Alzheimer's disease (AD). SORL1 encodes the sorting-related receptor with A repeat (SORLA) protein, which belongs to the VPS10 receptor ...
Clinical progression and genetic pathways in body-first and brain-first Parkinson's disease [0.03%]
帕金森病体先型和脑先型的临床进展与遗传途径
Massimiliano Passaretti,Daniel Veréb,Mite Mijalkov et al.
Massimiliano Passaretti et al.
Background: Parkinson’s disease (PD) is a highly heterogeneous disorder with distinct phenotypes that can develop well before motor symptoms appear. Recently, two main phenotypes based on the different pathological sprea...
Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer's disease through disrupted regulated intramembrane proteolysis [0.03%]
PSEN1突变通过干扰调节性跨膜蛋白水解促进阿尔茨海默病小胶质细胞炎症反应
Oliver J Ziff,Gustavo Morrone Parfitt,Sarah Jolly et al.
Oliver J Ziff et al.
Background: Mutations in PSEN1 cause familial Alzheimer's disease with almost complete penetrance. Age at onset is highly variable between different PSEN1 mutations and even within families with the same mutation. Current...
sPLA2-IIA modifies progranulin deficiency phenotypes in mouse models [0.03%]
sPLA2-IIA修饰小鼠模型的原颗粒素缺乏表型
Cha Yang,Huan Du,Gwang Bin Lee et al.
Cha Yang et al.
Background: Haploinsufficiency of the progranulin (PGRN) protein is a leading cause of frontotemporal lobar degeneration (FTLD). Mouse models have been developed to study PGRN functions. However, PGRN deficiency in the co...
Interrogating the plasma proteome of repetitive head impact exposure and chronic traumatic encephalopathy [0.03%]
重复性脑震荡和慢性创伤性脑病的血浆蛋白组学研究
Rowan Saloner,Kaitlin B Casaletto,Sruti Rayaprolu et al.
Rowan Saloner et al.
Background: Exposure to repetitive head impacts (RHI) is associated with increased risk for chronic traumatic encephalopathy (CTE), a neurodegenerative tauopathy, and other neuropathological changes. Biological drivers of...
Myelin dysfunction in aging and brain disorders: mechanisms and therapeutic opportunities [0.03%]
髓鞘功能障碍在衰老和脑疾病中的机制及治疗机会
Zhihai Huang,Yulan Zhang,Peibin Zou et al.
Zhihai Huang et al.
Myelin is a multilamellar membrane that surrounds axons in the vertebrate nervous system. Properly functioning myelin is essential for the rapid conduction of nerve impulses, and it metabolically supports axonal integrity. Emerging evidence...