A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Lei-gong-gen formula granule on a spontaneously hypertensive rat model [0.03%]
基于网络药理学探究雷公根配方颗粒在自发性高血压大鼠模型中的活性成分及分子机制
Qiaofeng Li,Taijin Lan,Songhua He et al.
Qiaofeng Li et al.
Background: Lei-gong-gen formula granule (LFG) is a folk prescription derived from Zhuang nationality, the largest ethnic minority among 56 nationalities in China. It consists of three herbs, namely Eclipta prostrata (L.)...
New bakuchiol dimers from Psoraleae Fructus and their inhibitory activities on nitric oxide production [0.03%]
Psoraleae Fructus中新的一种白千层二聚体及其对一氧化氮产生的抑制活性
Qingxia Xu,Qian Lv,Lu Liu et al.
Qingxia Xu et al.
Background: Dried fruits of Psoralea corylifolia L. (Psoraleae Fructus) is one of the most popular traditional Chinese medicine with treatment for nephritis, spermatorrhea, pollakiuria, asthma, and various inflammatory di...
Shikonin attenuates rheumatoid arthritis by targeting SOCS1/JAK/STAT signaling pathway of fibroblast like synoviocytes [0.03%]
茜草素通过靶向类风湿滑膜细胞SOCS1/JAK/STAT信号通路减轻类风湿性关节炎
Lianhua He,Huijie Luan,Juan He et al.
Lianhua He et al.
Background: Rheumatoid arthritis is a progressive and systemic autoimmune disease seriously compromises human health. Fibroblast like synoviocytes are the major effectors of proliferation and inflammation in rheumatoid ar...
Neurobehavioral alternations of the female offspring born to polycystic ovary syndrome model rats administered by Chinese herbal medicine [0.03%]
中药对多囊卵巢综合征模型大鼠所生雌性后代神经行为学改变的影响
Xian Zhang,Lifang You,Xiaohui Zhang et al.
Xian Zhang et al.
Background: Chinese herbal medicine (CHM) has significant effects that improve the reproductive functions of patients with polycystic ovary syndrome (PCOS). However, the intergenerational effects of CHM on offspring and t...
Marchantia polymorpha L. ethanol extract induces apoptosis in hepatocellular carcinoma cells via intrinsic- and endoplasmic reticulum stress-associated pathways [0.03%]
马齿苋L.乙醇提取物通过内在的和内质网应力相关的途径诱导肝癌细胞凋亡
Fangfang Zhou,Adila Aipire,Lijie Xia et al.
Fangfang Zhou et al.
Background: Marchantia polymorpha L. is a kind of Chinese herbal medicine and has various biological activities including antioxidant and antifungal. However, it is not clear about the antitumor effect and mechanism of M....
Chemical profiles and metabolite study of raw and processed Cistanche deserticola in rats by UPLC-Q-TOF-MSE [0.03%]
基于UPLC-Q-TOF-MSE技术的生、制肉苁蓉在大鼠体内的化学成分及代谢产物研究
Zhe Li,Lkhaasuren Ryenchindorj,Bonan Liu et al.
Zhe Li et al.
Background: Chinese materia medica processing is a distinguished and unique pharmaceutical technique in Traditional Chinese Medicine (TCM) used for reducing side effects, and increasing or even changing therapeutic effica...
Mechanism exploration of Gouqi-wentang formula against type 2 diabetes mellitus by phytochemistry and network pharmacology-based analysis and biological validation [0.03%]
基于植物化学和网络药理学分析及生物验证探讨构杞温糖方抗2型糖尿病的机制研究
Lin Han,Hao-Yu Yang,Yu-Jiao Zheng et al.
Lin Han et al.
Background: The Gouqi-wentang formula (GQWTF) is a herbal formula used by Academician Xiao-lin Tong for the clinical treatment of T2DM. GQWTF is beneficial to qi, nourishes Yin, clears heat, and promotes fluid production,...
Oral colon-targeting core-shell microparticles loading curcumin for enhanced ulcerative colitis alleviating efficacy [0.03%]
负载姜黄素的口服结肠定位核壳型微粒在溃疡性结肠炎治疗中的增效作用研究
Chen Zhang,Zhejie Chen,Yanan He et al.
Chen Zhang et al.
Background: The oral colon-targeting drug delivery vehicle is vital for the efficient application of curcumin (Cur) in ulcerative colitis (UC) treatment because of its lipophilicity and instability in the gastrointestinal...
UPLC-MS/MS method for simultaneously determining nucleosides and methyl-nucleosides in liver mRNA of Epimedin C-induced liver injury mouse model [0.03%]
赵思佳
Zhizhen Song,Zeyun Li,Xueqian Wen et al.
Zhizhen Song et al.
Background: Epimedin C, one of the main active ingredients of Epimedium, has been reported to have potential hepatotoxicity. However, the mechanism of Epimedin C-induced liver injury has not been studied. mRNA methylation...
Hierarchical chromatin features reveal the toxin production in Bungarus multicinctus [0.03%]
多带眼镜蛇毒素产生的分层染色质特征分析
Xuejiao Liao,Shuai Guo,Xianmei Yin et al.
Xuejiao Liao et al.
Background: Bungarus multicinctus, from which a classical Chinese medicine is produced, is known as the most venomous land snake in the world, but the chromatin organization and transcription factor activity during venom ...