Myocardial protective effect and transcriptome profiling of Naoxintong on cardiomyopathy in zebrafish [0.03%]
脑心通对斑马鱼心脏肌病的保护作用及其转录组分析
Mengyan Hu,Peirong Liu,Shuxian Lu et al.
Mengyan Hu et al.
Background: Cardiomyopathy is a kind of cardiovascular diseases, which makes it more difficult for the heart to pump blood to other parts of the body, eventually leading to heart failure. Naoxintong (NXT), as a traditiona...
Efficacy and safety of Chinese medicine JCM-16021 for diarrhea-predominant irritable bowel syndrome: study protocol for a multi-center, randomized, double-blind, placebo controlled clinical trial [0.03%]
中药JCM-16021治疗腹泻型肠易激综合症的疗效和安全性研究：多中心、随机、双盲、安慰剂对照临床试验方案
Ya Zheng,Jessica Ching,Chung Wah Cheng et al.
Ya Zheng et al.
Background: Irritable bowel syndrome (IBS) is a common gastrointestinal functional disease. Adults with IBS may experience abdominal pain, change of bowel habits, and abnormal stool form without organic disease. IBS can s...
Curcumin prevents As3+-induced carcinogenesis through regulation of GSK3β/Nrf2 [0.03%]
姜黄素通过调节GSK3β/Nrf2来预防As3+诱导的肿瘤生成
Yuan-Ye Dang,Hua Luo,Yong-Mei Li et al.
Yuan-Ye Dang et al.
Background: Arsenic (As3+) is a carcinogen with considerable environmental and occupational relevancy. Its mechanism of action and methods of prevention remain to be investigated. Previous studies have demonstrated that R...
Honokiol attenuates lipotoxicity in hepatocytes via activating SIRT3-AMPK mediated lipophagy [0.03%]
honokiol通过激活SIRT3-AMPK介导的脂噬来减轻肝细胞的脂毒性
Jingxin Liu,Tian Zhang,Jianzhong Zhu et al.
Jingxin Liu et al.
Background: Non-alcoholic fatty liver disease (NAFLD) is characterized by ectopic accumulation of triglycerides in the liver. Emerging evidence has demonstrated that lipophagy regulates lipid mobilization and energy homeo...
Honokiol attenuates lipotoxicity in hepatocytes via activating SIRT3-AMPK mediated lipophagy [0.03%]
honokiol通过激活SIRT3-AMPK介导的脂噬来减轻肝细胞的脂毒性
Jingxin Liu,Tian Zhang,Jianzhong Zhu et al.
Jingxin Liu et al.
Background: Non-alcoholic fatty liver disease (NAFLD) is characterized by ectopic accumulation of triglycerides in the liver. Emerging evidence has demonstrated that lipophagy regulates lipid mobilization and energy homeo...
Therapeutic potential of triptolide in autoimmune diseases and strategies to reduce its toxicity [0.03%]
雷公藤红素在自身免疫性疾病中的治疗潜力及其减毒策略
Yaxin Cheng,Yonghua Zhao,Ying Zheng
Yaxin Cheng
With the increasing epidemiology of autoimmune disease worldwide, there is an urgent need for effective drugs with low cost in clinical treatment. Triptolide, the most potent bioactive compound from traditional Chinese herb Tripterygium Wil...
An alcohol extract prepared from the male flower of Eucommia ulmoides Oliv. promotes synoviocyte apoptosis and ameliorates bone destruction in rheumatoid arthritis [0.03%]
杜仲雄花的乙醇提取物促进滑膜细胞凋亡并改善类风湿关节炎的骨破坏
Yan Zhang,Jian-Ying Wang,Hao Wang et al.
Yan Zhang et al.
Background: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease dominated by synovial hyperplasia and bone destruction. The male flower of Eucommia ulmoides Oliv. (EF) has been shown to exert effects on the...
Si-Wu-Tang ameliorates fibrotic liver injury via modulating intestinal microbiota and bile acid homeostasis [0.03%]
四物汤通过调节肠道微生物群和胆汁酸稳态改善肝脏纤维化损伤
Xiaoyong Xue,Jianzhi Wu,Mingning Ding et al.
Xiaoyong Xue et al.
Background: Fibrotic liver injury is a progressive scarring event, which may permanently affect liver function and progress into devastating end-stage liver diseases due to the absence of effective therapies. Si-Wu-Tang (...
Huiyang Shengji decoction promotes wound healing in diabetic mice by activating the EGFR/PI3K/ATK pathway [0.03%]
惠阳圣济汤通过激活EGFR / PI3K / ATK通道促进糖尿病小鼠伤口愈合
Qingwu Liu,Jinchao Zhang,Xuyang Han et al.
Qingwu Liu et al.
Background: Common chronic wounds include diabetic ulcers, venous ulcers, and pressure ulcers. The traditional Chinese medicine Huiyang Shengji decoction (HYSJD) has been shown to promote the healing of diabetic chronic w...
Comparison of the chemical constituents and anti-Alzheimer's disease effects of Uncaria rhynchophylla and Uncaria tomentosa [0.03%]
钩藤和秘鲁麻化学成分及抗阿尔茨海默病作用的比较研究
Qing-Qing Xu,Pang Chui Shaw,Zhen Hu et al.
Qing-Qing Xu et al.
Background: Uncaria tomentosa, which has similar chemical constituents with Uncaria rhynchophylla, has been reported to alleviate cognitive impairments in Alzheimer's disease (AD) animal models. This study aimed to compar...