Shen-Zhi-Ling oral liquid ameliorates cerebral glucose metabolism disorder in early AD via insulin signal transduction pathway in vivo and in vitro [0.03%]
Shen之灵口服液通过胰岛素信号转导通路改善早衰AD的小脑葡萄糖代谢紊乱(体内和体外)
Gaofeng Qin,Yunfang Dong,Zhenhong Liu et al.
Gaofeng Qin et al.
Background: Shen-Zhi-Ling oral liquid (SZL) is an herbal formula known for its efficacy of nourishing "heart and spleen", and is used for the treatment and prevention of middle- and early-stage dementia. This study invest...
Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo [0.03%]
honokiol通过激活Nrf2抑制NLRP3炎性小体介导的焦亡来缓解LPS诱导的急性肺损伤体内和体外实验研究
Yuhan Liu,Jiabin Zhou,Yingying Luo et al.
Yuhan Liu et al.
Background: Honokiol (HKL) has been reported to ameliorate lipopolysaccharide (LPS)-induced acute lung injury (ALI). However, its potential mechanism of its protective effects remains unclear. In this study, the protectiv...
Integrated DIA proteomics and lipidomics analysis on non-small cell lung cancer patients with TCM syndromes [0.03%]
非小细胞肺癌中医证候的整合DIA蛋白质组学和脂质组学分析
Song Cang,Ran Liu,Wei Jin et al.
Song Cang et al.
Background: Lung cancer remains the leading cause of mortality from malignant tumors, non-small cell lung cancer (NSCLC) accounts for the majority of lung cancer cases, and individualized diagnosis and treatment is an eff...
Comparative and phylogenetic analyses of eleven complete chloroplast genomes of Dipterocarpoideae [0.03%]
Dipterocarpoideae十一号完整叶绿体基因组的比较和系统发生分析
Yang Yu,Yuwei Han,Yingmei Peng et al.
Yang Yu et al.
Background: In South-east Asia, Dipterocarpoideae is predominant in most mature forest communities, comprising around 20% of all trees. As large quantity and high quality wood are produced in many species, Dipterocarpoide...
Integrating network pharmacological and experimental models to investigate the therapeutic effects of baicalein in glaucoma [0.03%]
整合网络药理学和实验模型研究黄酮在青光眼中的治疗效果
Jiawei Yang,Mingxu Zhang,Qiuyi Song et al.
Jiawei Yang et al.
Background: Traditional Chinese medicine (TCM) has a long history of treating glaucoma with remarkable effects, but there is no clear conclusion on its mechanism. ...
Aloin induced apoptosis by enhancing autophagic flux through the PI3K/AKT axis in osteosarcoma [0.03%]
Aloin通过PI3K/AKT轴增强自噬流诱导骨肉瘤细胞凋亡
Jiaming He,Wenkan Zhang,Xiaozhong Zhou et al.
Jiaming He et al.
Background: Osteosarcoma is a malignant tumor of bone and soft tissue in adolescents. Due to its tumor biological behavior pattern, osteosarcoma usually generates poor prognosis. Autophagy is an important self-defense mec...
A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation [0.03%]
基于WGCNA及体外实验验证的复方苦参注射液治疗胰腺癌的网络药理学研究及其作用靶点和生物机制探索
Chao Wu,Zhi-Hong Huang,Zi-Qi Meng et al.
Chao Wu et al.
Background: Compound kushen injection (CKI), a Chinese patent drug, is widely used in the treatment of various cancers, especially neoplasms of the digestive system. However, the underlying mechanism of CKI in pancreatic ...
Contents of lobetyolin, syringin, and atractylolide III in Codonopsis pilosula are related to dynamic changes of endophytes under drought stress [0.03%]
龙胆甲素、紫草苷和当归酰内酯III在不同干旱胁迫下党参内生菌动态变化中的含量关系研究
Yichuan Liang,Guangfei Wei,Kang Ning et al.
Yichuan Liang et al.
Background: Codonopsis pilosula, an important medicinal plant, can accumulate certain metabolites under moderate drought stress. Endophytes are involved in the metabolite accumulations within medicinal plants. It is still...
A correlational study of Weifuchun and its clinical effect on intestinal flora in precancerous lesions of gastric cancer [0.03%]
胃癌前病变中卫馥春与肠道菌群临床效果的相关性研究
Yanqin Bian,Xi Chen,Hongyan Cao et al.
Yanqin Bian et al.
Background: Weifuchun (WFC), a Chinese herbal prescription consisting of Red Ginseng, Isodon amethystoides and Fructus Aurantii, is commonly used in China to treat a variety of chronic stomach disorders. The aim of the pa...
Buyang Huanwu Decoction protects against STZ-induced diabetic nephropathy by inhibiting TGF-β/Smad3 signaling-mediated renal fibrosis and inflammation [0.03%]
买阳还五 decoction 通过抑制 TGF-β/Smad3 信号介导的肾纤维化和炎症来抵抗由 STZ 引起的糖尿病肾病
Weifeng Wu,Yifan Wang,Haidi Li et al.
Weifeng Wu et al.
Background: Buyang Huanwu Decoction (BHD) is a classical Chinese Medicine formula empirically used for diabetic nephropathy (DN). However, its therapeutic efficacies and the underlying mechanisms remain obscure. In our st...