P2Y12 receptor as a new target for electroacupuncture relieving comorbidity of visceral pain and depression of inflammatory bowel disease [0.03%]
P2Y12受体作为电针缓解炎症性肠病内脏痛共病抑郁的新靶点
Yanzhen Li,Hong Zhang,Jingwen Yang et al.
Yanzhen Li et al.
Background: The P2Y12 receptor is a kind of purinoceptor that is engaged in platelet aggregation, and P2Y12 inhibitors have been used in clinical antithrombotic therapy. The P2Y12 receptor in microglia induces interleukin...
Acupressure in patients with seasonal allergic rhinitis: a randomized controlled exploratory trial [0.03%]
季节性过敏性鼻炎患者的穴位按压法：随机对照探索性试验
Lukas Israel,Gabriele Rotter,Ulrike Förster-Ruhrmann et al.
Lukas Israel et al.
Background: Acupuncture has shown beneficial effects for seasonal allergic rhinitis (SAR); however, it is time and cost intensive. We investigated feasibility and effects of self-administered body acupressure as a self-ca...
Perillaldehyde improves cognitive function in vivo and in vitro by inhibiting neuronal damage via blocking TRPM2/NMDAR pathway [0.03%]
垂藤醛通过阻断TRPM2/NMDAR信号通路抑制神经元损伤改善认知功能
Yue Qiu,Xian-Jun Xue,Geng Liu et al.
Yue Qiu et al.
Background: Vascular cognitive dysfunction in patients with vascular dementia (VD) is a kind of severe cognitive dysfunction syndrome caused by cerebrovascular diseases. At present, effective drugs to improve the cognitiv...
Mechanism of drug-induced liver injury and hepatoprotective effects of natural drugs [0.03%]
药物性肝损伤机制及天然药物保肝作用研究
Yongfeng Zhou,Junnan Wang,Dingkun Zhang et al.
Yongfeng Zhou et al.
Drug-induced liver injury (DILI) is a common adverse drug reaction (ADR) and a serious threat to health that affects disease treatments. At present, no targeted clinical drugs are available for DILI. Traditional natural medicines have been ...
Roles of reactive oxygen species, mitochondrial membrane potential, and p53 in evodiamine-induced apoptosis and G2/M arrest of human anaplastic thyroid carcinoma cells [0.03%]
桂皮色胺诱导人甲状腺癌细胞凋亡和G2/M期阻滞中活性氧,线粒体膜电位和p53的作用
Chih-Chiang Chien,Ming-Shun Wu,Shih-Wei Chou et al.
Chih-Chiang Chien et al.
Background: Our previous studies have shown that evodiamine (EVO) as paclitaxel and nocodazole could trigger apoptosis in various human cancer cells including human renal cell carcinoma cells, colorectal carcinoma cells, ...
Traditional chinese medicine syndromes classification associates with tumor cell and microenvironment heterogeneity in colorectal cancer: a single cell RNA sequencing analysis [0.03%]
传统中医证候分类与结直肠癌肿瘤细胞和微环境异质性的关联：单细胞RNA测序分析
Yiyu Lu,Chungen Zhou,Meidong Zhu et al.
Yiyu Lu et al.
Background: Colorectal cancer (CRC) is one of the common gastrointestinal malignancies, tumor heterogeneity is the main cause of refractory CRC. Syndrome differentiation is the premise of individualized treatment of tradi...
Neurogenesis-dependent antidepressant-like activity of Hericium erinaceus in an animal model of depression [0.03%]
齿孔菌的抗抑郁作用及其在动物模型中的神经发生依赖性活性研究
Pit Shan Chong,Chi Him Poon,Jaydeep Roy et al.
Pit Shan Chong et al.
Background: Depression is a severe neuropsychiatric disorder that affects more than 264 million people worldwide. The efficacy of conventional antidepressants are barely adequate and many have side effects. Hericium erina...
Bletilla striata polysaccharide cryogel scaffold for spatial control of foreign-body reaction [0.03%]
用于控制异物反应的斑兰玉凤花多糖冷冻凝胶支架
Jiaxi Chen,Huiqun Zhou,Daping Xie et al.
Jiaxi Chen et al.
Background: Implantation of a biomaterial may induce the foreign-body reaction to the host tissue that determines the outcome of the integration and the biological performance of the implants. The foreign-body reaction ca...
Efficacy and potential mechanisms of Chinese herbal compounds in coronavirus disease 2019: advances of laboratory and clinical studies [0.03%]
中药复方在新型冠状病毒肺炎中的疗效及潜在机制：实验和临床研究的进展
Mu-Feng Xiang,Cheng-Tao Jin,Li-Hua Sun et al.
Mu-Feng Xiang et al.
The Coronavirus disease 2019 (COVID-19) pandemic is still spread and has made a severe public health threat around the world. To improve disease progression, emerging Chinese herbal compounds were used in clinical practice and some agents h...
Traditional Chinese Medicine for adjuvant treatment of breast cancer: Taohong Siwu Decoction [0.03%]
中药作为乳腺癌辅助治疗：桃红四物汤
Huajuan Jiang,Minmin Li,Kequn Du et al.
Huajuan Jiang et al.
The high incidence of breast cancer is the greastest threat to women' health all over the world. Among them, HER-2 positive breast cancer has the characteristics of high malignancy, easy recurrence and metastasis, and poor prognosis. Tradit...