Buyang Huanwu Decoction promotes neurorepair after spinal cord injury through a Lactobacillus johnsonii-indole-3-lactic acid-AhR-PI3K/Akt axis [0.03%]
补阳还五汤通过肠菌-色氨酸代谢-AhR信号促进脊髓损伤后神经修复
Jinwang Dong,Yang Cao,Xiujin Chen et al.
Jinwang Dong et al.
Background: Spinal cord injury (SCI) induces gut microbiota dysbiosis, which significantly affects recovery. Buyang Huanwu Decoction (BHD), a traditional Chinese medicine formula, has shown therapeutic effects on SCI. Alt...
Research progress on the mechanisms of Panax ginseng and its active components in maintaining skin homeostasis and disease intervention [0.03%]
人参及其活性成分调控皮肤稳态和疾病治疗的研究进展
Lu Ding,Zihan Wang,Nanqi Hou et al.
Lu Ding et al.
Panax ginseng (Panax ginseng C.A. Meyer) is a classic herbal medicine widely utilized in dermatological management, yet its precise therapeutic mechanisms have only recently begun to be fully elucidated. This review systematically synthesiz...
TRPV1 in skeletal muscles mediates the improvement of cardiac function induced by acupuncture at the PC6 acupoint in rats with acute myocardial infarction [0.03%]
针刺内关穴通过骨骼肌瞬时受体电位香草素1通道介导急性心梗大鼠心脏功能改善的作用及机制研究
Xue Liu,Yongjian Wu,Yongxiao Zhai et al.
Xue Liu et al.
Background: The acupoint is the initial response site to acupuncture stimulation, and changes in the acupoint affect the subsequent therapeutic effects of acupuncture. However, the mechanism of acupuncture from this initi...
Shuangshen granules enhance anti-PD1 therapy effectiveness in lung adenocarcinoma by modulating myeloid-derived suppressor cell-induced T cell exhaustion [0.03%]
双神颗粒通过调节髓源抑制细胞诱导的T细胞衰竭增强抗PD-1治疗在肺腺癌中的疗效
Zhong-Ning He,Qi Huang,Yi Li et al.
Zhong-Ning He et al.
Background: Worldwide, lung cancer is the most common cause of cancer-related deaths. Molecular targeted therapies and immunotherapies for non-small-cell lung cancer (NSCLC) have improved outcomes markedly over the past t...
A stabilized enrichment method for rosemary diterpenoids and their therapeutic potential in diabetic kidney disease [0.03%]
一种岩玫瑰二萜类成分富集方法及其对糖尿病肾脏疾病的潜在疗效研究
Jiali Wei,Qian Xiao,Hua Yang et al.
Jiali Wei et al.
Background: As a traditional medicinal herb, rosemary leaves have shown potential for the treatment for diabetic kidney disease (DKD). However, the bioactive compounds responsible for its anti-DKD effects remain unidentif...
Chemical proteomics reveals sinomenine's anti-inflammatory mechanism through serum protein covalent modification [0.03%]
化学蛋白质组学揭示了青风藤碱通过血液蛋白共价修饰发挥抗炎作用的机制
Meixian Liu,Zhiyuan Zheng,Yida Zhang et al.
Meixian Liu et al.
Background: Covalent protein modification by drugs or their reactive metabolites has emerged as an important mechanism underlying pharmacological activity. However, its contribution to the therapeutic effects of compounds...
Shexiang Tongxin Dropping Pills targeting Piezo1/Ca2+/NLRP3 axis attenuates vascular endothelial inflammation [0.03%]
麝香通心滴丸通过作用于Piezo1/Ca2+/NLRP3轴减轻血管内皮炎症反应
Jingya Liu,Ke Wang,Hongjing You et al.
Jingya Liu et al.
Background: Vascular endothelial inflammation is a key pathological process underlying various inflammatory vascular conditions, which can lead to severe cardiovascular complications. Shexiang Tongxin Dropping Pills (STDP...
Targeting tumor-associated macrophages through phytochemicals: a promising strategy for cold tumor therapy [0.03%]
植物化学物质靶向肿瘤相关巨噬细胞：冷肿瘤治疗的潜在策略
Tian Shue,Yujun Guo,Peishan Zhou et al.
Tian Shue et al.
Immunotherapy serves as the fourth modality for cancer treatment, following surgery, radiotherapy, and chemotherapy. However, its efficacy remains inconsistent due to the heterogeneity of the tumor microenvironment (TME). Tumors characteriz...
Qinggan Jianpi formula attenuates atherosclerosis by suppressing macrophage lactate transport to activate repair genes via H3K18 lactylation [0.03%]
清肝健脾方通过抑制巨噬细胞乳酸转运激活修复基因（H3K18乳酰化）从而改善动脉粥样硬化功效的研究
Xuefeng Zhuang,Rui Zhang,Jiatong Sun et al.
Xuefeng Zhuang et al.
Background: Atherosclerosis (AS) is a complex vascular disease characterized by lipid accumulation, chronic inflammation, and immune dysregulation. Qinggan Jianpi Formula (QGJP), a traditional Chinese medicinal preparatio...
FeiyanHeji multifunctionally inhibits influenza virus via PA protein degradation and RIG-I signaling pathway potentiation [0.03%]
菲扬合剂通过降解PA蛋白及激活RIG-I信号通路多重抑制流感病毒
Tongtong Cao,Wenqiang Sun,Yan Hu et al.
Tongtong Cao et al.
Influenza virus infection can lead to high mortality and severe disease complicated by secondary bacterial pneumonia. FeiyanHeji (FyHj) is a traditional Chinese medicine (TCM) mixture used clinically to treat pneumonia caused by influenza, ...