Electroacupuncture stimulation improves pulmonary fibrosis by modulating ferroptosis in rats: multiscale analysis of transcriptome and proteome [0.03%]
电针调节铁死亡改善肺纤维化的多尺度转录组和蛋白质组分析研究
Yange Tian,Qinghua Song,Ruilong Lu et al.
Yange Tian et al.
Background: Idiopathic Pulmonary fibrosis (IPF) is a progressive lung disease with poor survival. Electroacupuncture has been proven to improve dyspnea in IPF patients, but the mechanism remains unclear. ...
Identification of anti-fibrotic compounds from Piper longum L via hollow fiber cell fishing and high-performance liquid chromatography with in vivo and in vitro validation [0.03%]
雷丸抗纤维化成分的体内-体外筛选模型及其活性成分研究
Jie Tian,Nan Zhou,Heng Wang et al.
Jie Tian et al.
Background: Traditional Chinese medicine (TCM) is an important source of bioactive compounds, hence enjoying a wide application in clinical treatment, while its pharmacodynamic material basis remains difficult to elucidat...
Emodin promotes GSK-3β-mediated PD-L1 proteasomal degradation and enhances anti-tumor immunity in hepatocellular carcinoma [0.03%]
蒽林通过GSK-3β介导的PD-L1蛋白酶体降解促进肝细胞癌的抗肿瘤免疫反应
Xuemei Yang,Weiguang Chen,Haitao Sun et al.
Xuemei Yang et al.
Background: Programmed death-ligand 1 (PD-L1), a prominent immune checkpoint, interacts with programmed death protein-1 (PD-1) on cytotoxic T cells within tumors and promotes immune evasion. Emodin, which is known to dest...
Moxibustion ameliorates abnormal subchondral bone remodeling by promoting ACSL1-mediated autophagy to degrade NLRP3 in osteoarthritis [0.03%]
艾灸通过促进ACSL1介导的自噬降解NLRP3改善骨关节炎软骨下骨异常重建
Xuelan Chen,Liping Fu,Yu Huang et al.
Xuelan Chen et al.
Background: Osteoarthritis (OA) is a joint disorder that is characterized, among other features, by abnormal subchondral bone remodeling. Moxibustion, a traditional Chinese medicine treatment, has a long history in the cl...
Correction: Plant-derived extracts or compounds for Helicobacter-associated gastritis: a systematic review of their anti-Helicobacter activity and anti-inflammatory effect in animal experiments [0.03%]
植物来源的抗幽门螺旋杆菌胃炎提取物或化合物的系统评价：实验动物的抗幽门螺旋杆菌活性和抗炎作用的矫正分析
Danni Chen,Wenlai Wang,Xiangyun Chen et al.
Danni Chen et al.
Published Erratum
Chinese medicine. 2025 Aug 8;20(1):124. DOI:10.1186/s13020-025-01139-5 2025
Triptolide targets PPP2CA/ITGA5 axis to suppress lactate-driven ovarian cancer progression [0.03%]
三尖杉酯碱通过靶向PPP2CA/ITGA5轴抑制卵巢癌的乳酸驱动进展
Ling Ding,Wutao Chen,Cenxin Luo et al.
Ling Ding et al.
Background: Triptolide, the active compound of Tripterygium wilfordii, exhibits broad anti-tumor activity. This study explores PPP2CA dysregulation in ovarian cancer (OC) progression via lactate production and evaluates T...
Huanglian Jiedu Decoction improves the"central-peripheral"inflammatory microenvironment and enhances the cognitive function of APP/PS1 mice by inhibiting the activation of NLRP3 inflammasome mediated by gut microbiota [0.03%]
黄连解毒汤通过抑制肠道菌群介导的NLRP3炎症小体活化改善APP/PS1小鼠“中枢-外周”炎性微环境及认知功能
Yani Zhang,Jiahua Wang,Xuetao Li et al.
Yani Zhang et al.
Background: Huanglian Jiedu Decoction (HLJDD) is a representative formula for clearing heat and removing toxins, and some basic studies indicated that it can improve the learning cognitive ability of Alzheimer's disease (...
Regulatory mechanisms of hepatocyte PCSK9 expression: translating mechanistic insights into potential nutraceuticals [0.03%]
肝细胞PCSK9表达的调控机制：从潜在的作用机制透视营养药物的发展方向
Seon Kyeong Park,Jin-Taek Hwang,Hyo-Kyoung Choi et al.
Seon Kyeong Park et al.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a critical regulator of cholesterol metabolism in hepatocytes with profound implications for cardiovascular health. This review explores the intricate regulatory network that controls...
Explore the potential mechanism of Huachansu injection against osteosarcoma via metabolomics, network pharmacology and bioinformatics [0.03%]
基于代谢组学、网络药理学及生物信息学的华蟾素注射液抗骨肉瘤机制探讨
Jingjing Meng,Xiangqi Zhang,Danfeng Xiang et al.
Jingjing Meng et al.
Aim: Huachansu injection (HCSI) shows effective medicinal functions against osteosarcoma. This study aimed to reveal the underlying mechanisms of HCSI against osteosarcoma by integrating metabolomics, network pharmacology...
Baitouweng decoction modulates gut microbial production of indole-3-propionic acid and epithelial necroptosis to alleviate DSS-induced colitis in mice [0.03%]
baitouweng汤通过调节肠道微生物产生印防己酸和上皮细胞坏死性凋亡来缓解小鼠dss诱导的结肠炎
Jingyi Hu,Hongxin Chen,Lei Zhu et al.
Jingyi Hu et al.
Background: Ulcerative colitis (UC) is a kind of inflammatory disorder structuring in the colon. Baitouweng decoction (BD) derived from Treatise on Cold Damage (Shang-Han-Lun in Chinese) has been used for the treatment of...