Sodium tanshinone IIA sulfonate alleviates osteoarthritis through targeting SIRT1 [0.03%]
sodium tanshinone IIA 磺酸盐通过作用于SIRT1来缓解骨关节炎
Mao Xu,Xulei Sun,Xiao Ma et al.
Mao Xu et al.
Background: Osteoarthritis (OA), a chronic degenerative disease, is characterized by the loss of articular cartilage, impacting more than 500 million individuals worldwide. Sodium tanshinone IIA sulfonate (STS) is a water...
Impact of Traditional Chinese Medicine therapy focused on strengthening the body on postoperative recurrence and metastasis prevention in stage IIIA non-small cell lung cancer: a real-world retrospective cohort study [0.03%]
基于健脾补肾法的中医药治疗对IIIa期非小细胞肺癌术后复发和远处转移影响的队列研究
Ruoyan Qin,Yi Jiang,Liping Shen et al.
Ruoyan Qin et al.
Background: This study aimed to evaluate the impact of Traditional Chinese Medicine (TCM) therapy focused on strengthening the body on postoperative recurrence and metastasis prevention in patients with stage IIIA non-sma...
Maimendong decoction and its active ingredient, ophiopogonin D, alleviate bleomycin-induced pulmonary fibrosis by regulating the behavior of lung fibroblasts [0.03%]
麦门冬汤及其活性成分ophiopogonin D通过调节肺成纤维细胞的表型抑制bleomycin诱导的大鼠肺纤维化
Mingjie Yang,Xinyue Zhang,Shengchuan Bao et al.
Mingjie Yang et al.
Background: Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by progressive scarring of lung tissue, which can lead to respiratory failure and other serious complications, making the search for ...
Sea cucumber polypeptide ameliorates aging properties via the brain-gut axis in naturally aging mice [0.03%]
海参肽通过脑-肠轴改善小鼠的衰老表型
Chao Feng,Yiwen Shou,Shulin Wu et al.
Chao Feng et al.
Background: Sea cucumber has been recognized as a traditional nutraceutical in Chinese medicine for millennia, with its derived polypeptide (SCP) demonstrating diverse bioactive properties. Nevertheless, the molecular mec...
Inter-species and individualized biotransformation of five saponins by human being- and mouse-derived fecal microbiota [0.03%]
人和小鼠来源粪便菌群对五种皂苷的物种间与个体间的生物转化差异研究
Wenjing Wei,Mingxiao Li,Lingyun Pan et al.
Wenjing Wei et al.
Background: The gut microbiota plays a critical role in the biotransformation of saponins. However, current research predominantly focuses on metabolism by single microbial species, with limited investigation into inter-s...
Multi-omics analysis reveals ACOT1 as the key target of piperine in Piper Longum-mediated gastric cancer treatment [0.03%]
多组学分析揭示了胡椒碱在长柄胡椒介导的胃癌治疗中靶向ACOT1的关键作用
Boyu Pan,Ling Liu,Xiaofeng Wang et al.
Boyu Pan et al.
Background: Piper longum demonstrates significant therapeutic potential against gastric cancer (GC), but its underlying mechanisms remain incompletely understood. This study aimed to establish a comprehensive multi-omics ...
Yuye Jinhua Qingre Tablets Attenuate Acute Pharyngitis by inhibiting the Complement Cascade and C5a/C5aR1 Axis [0.03%]
银菊金花清热片通过抑制补体级联及C5a/C5aR1轴治疗急性咽炎
Yifei Gao,Leiming You,Jiying Zhou et al.
Yifei Gao et al.
Background: Acute pharyngitis (AP) is a common upper respiratory tract infection, primarily characterized by symptoms such as throat pain, redness, swelling, and difficulty swallowing. It is typically caused by viral infe...
Effects of acupuncture versus moxibustion on functional dyspepsia: a randomized clinical trial [0.03%]
针刺和艾灸治疗功能性消化不良的疗效比较：随机对照试验
Yangke Mao,Pan Zhang,Zhaoxuan He et al.
Yangke Mao et al.
Background: Functional dyspepsia (FD) is a prevalent gastrointestinal disorder, despite its high prevalence and impact on quality of life, effective treatments are limited. Acupuncture and moxibustion, two complementary t...
An exhaustive examination of the research progress in identifying potential JAK inhibitors from natural products: a comprehensive overview [0.03%]
一种来自天然产物的潜在JAK抑制剂的研究进展综述：全面概述
Wendong Yang,Jiabin Lu,Peihua Luo et al.
Wendong Yang et al.
The JAK-STAT signaling pathway serves as a central regulator of diverse cellular processes encompassing proliferation, apoptosis, inflammation, and differentiation. Specifically, extracellular ligands such as interleukins, and colony-stimul...
Sanren decoction ameliorates ulcerative colitis by modulating gut microbiota and macrophage polarization to enhance intestinal barrier function [0.03%]
三仁汤通过调节肠道菌群和巨噬细胞极化来改善溃疡性结肠炎以增强肠屏障功能
Shujuan Zhang,BangHua Li,Xiaoqun Han et al.
Shujuan Zhang et al.
Sanren Decoction (SRD), a traditional Chinese medicine formula historically used to relieve damp-heat and gastrointestinal disorders, demonstrates targeted efficacy in ulcerative colitis (UC)-a disease marked by chronic inflammation and muc...