Exploring the role of RCEO in macrophage-mediated modulation of pulmonary fibrosis [0.03%]
探究RCEO在巨噬细胞介导的肺纤维化调节中的作用
Zhiguo Mao,Xiangke Lin,Xingyi Yang et al.
Zhiguo Mao et al.
Background: Pulmonary fibrosis (PF) is an interstitial lung disease with macrophage polarization playing a critical role. Previous research has demonstrated that essential oil from Radix Curcumae (RCEO) significantly amel...
Targeting the gut‒kidney axis for lupus nephritis treatment: multimechanism regulatory strategies and evidence from Traditional Chinese medicine [0.03%]
靶向肠道-肾脏轴治疗狼疮性肾炎：多机制调节策略及中医药证据
Qingyun Fang,Jiabao Liu,Chen Xuan et al.
Qingyun Fang et al.
Lupus nephritis (LN) treatment remains challenging because of the limited efficacy and substantial side effects of conventional immunosuppressive therapies. Traditional Chinese medicine (TCM), with its holistic and multitarget approach, off...
Epigenetic precision diagnostics of traditional Chinese medicine (TCM) syndrome differentiation: a pilot study of atrial fibrillation with qi-yin deficiency syndrome based on 5-hydroxymethylcytosine signatures in extracellular vesicle DNA from plasma [0.03%]
基于血浆细胞外囊泡DNA的5-羟甲基胞嘧啶表观遗传精准诊断体系初探：房颤气阴两虚证的辨证研究
Shaowei Fan,Haoyu Chen,Hangyu Chen et al.
Shaowei Fan et al.
Background: Syndrome differentiation in Traditional Chinese Medicine (TCM) is pivotal to clinical practice and dictates the efficacy of medicinal treatments. However, precision diagnostic models for TCM syndromes, constru...
6-Shogaol inhibits HSCs activation and liver fibrosis by regulating glycolytic reprogramming via targeting HIF-1α [0.03%]
6-姜酚通过靶向HIF-1α调节糖酵解重编程抑制肝星状细胞活化和肝纤维化作用机制研究
Junfa Yang,Min Shu,Hui Fang et al.
Junfa Yang et al.
Background: Liver fibrosis is a representative scarring response that can ultimately lead to liver cancer. However, relevant antifibrotic drugs for the effective treatment of liver fibrosis in humans have not yet been ide...
Electroacupuncture prevents CUMS induced depressive-like behaviors by inhibiting microglia-mediated synaptic pruning induced by gut dysbiosis [0.03%]
电针通过抑制肠道菌群紊乱介导的突触修剪减轻慢性不可预测应激诱导的抑郁样行为
Lu Zhang,Jingyi Quan,Linlin Nie et al.
Lu Zhang et al.
Rationale: Electroacupuncture (EA) has been widely used for depression treatment. Microbiota-gut-brain (MGB) axis plays a vital role in regulating emotional behaviors. However, the potential role of MGB axis in EA-mediate...
Research advances in the application of betulinic acid for anti-inflammatory and anti-tumour therapy [0.03%]
Betulin酸抗炎及抗肿瘤作用研究进展
Zewen Chu,Shuaiyu Jiang,Yuting Li et al.
Zewen Chu et al.
Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid widely distributed in a variety of medicinal plants and has attracted considerable attention as an active constituent of several traditional herbal medicines. In recent y...
Research progress of biological processing of traditional Chinese medicine:fermentation and sprouting [0.03%]
中药生物加工研究进展：发酵与发芽
Jia-Qi Shi,Xiao-Ting Wang,Jia-Li Tian et al.
Jia-Qi Shi et al.
Aim: This paper presents a comprehensive review focusing on biological processing of traditional Chinese medicine. It reviews emerging modern fermentation technologies, as well as the two major aspects of biological proce...
Multi-omics analysis reveals that Danggui Buxue decoction ameliorates benzene-induced blood deficiency syndrome via the restoration of hematopoietic lineage and remodeling of the immune microenvironment [0.03%]
多组学分析揭示当归补血汤通过恢复造血谱系和重塑免疫微环境改善苯致血虚证
Hongda Liu,Junling Ren,Yu Hu et al.
Hongda Liu et al.
Blood deficiency syndrome (BDS) is a systemic disorder characterized by hematopoietic dysfunction and immune dysregulation. Given the limitations of current therapies, such as single efficacy and adverse effects, there is an urgent need for...
Integrating network pharmacology, transcriptomics, and experimental validation: Compound Baixianpi Formula targets IL-17A to inhibit dual PI3K-AKT/JAK2-STAT3 pathways for psoriasis improvement [0.03%]
基于网络药理学、转录组和实验验证的复方败藓片通过靶向IL-17A抑制双PI3K-AKT/JAK2-STAT3信号通路改善银屑病研究
Lin Tang,Yanli Wang,Yue Zhou et al.
Lin Tang et al.
Background: Psoriasis is an immune-mediated chronic inflammatory skin disease. Existing therapies have limitations, necessitating the development of new treatment approaches. Compound Baixianpi Formula (FFBXP) is a clinic...
Ya Han Jie ameliorates adjuvant-induced arthritis by inhibiting the NF-κB/NETosis/inflammation axis [0.03%]
Ya Han Jie通过抑制NF-κB/NETosis/炎症轴改善弗氏完全佐剂诱导的类风湿关节炎
Haixu Jiang,Jia Zeng,Enfan Xiao et al.
Haixu Jiang et al.
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease that mainly affects the joints. Ya Han Jie (YHJ) is a Dai medicine that has significant therapeutic effects on RA. However, the bioactive compounds and...