Thermodynamic-driven supramolecular transition from nanofibers to nanospheres: morphology-dependent antibacterial specificity of herb medicines [0.03%]
基于热力学驱动的超分子从纳米纤维到纳米球的转变及草药中天然产物的形态依赖性抗菌特性研究
Ji-Chang Wei,Xiao-Yu Lin,Yi-Hang Zhao et al.
Ji-Chang Wei et al.
Background: Scutellariae Radix (SR) and Coptidis Rhizoma (CR) are classic drug pairs used in clinical practice for clearing heat and drying dampness, purging fire for removing toxin. By further studying the mechanism of c...
Colla Corii Asini regulate collagen regeneration in UV exposure-induced skin photoaging in mice [0.03%]
驴皮提取物通过调节紫外线照射所致皮肤光老化小鼠胶原蛋白再生发挥抗皱功效作用机制研究
Yuman Ma,Jun Huang,Junxiao Gong et al.
Yuman Ma et al.
Background: Ultraviolet (UV) radiation is the primary external factor driving skin aging, mainly due to imbalanced collagen synthesis and degradation. Identifying new drugs targeting collagen regeneration may effectively ...
The association between acupuncture and response to immune checkpoint inhibitors in non-small cell lung cancer [0.03%]
针刺与非小细胞肺癌免疫检查点抑制剂疗效的关联分析
Rui Zhou,Yan-Juan Zhu,Yi-Han He et al.
Rui Zhou et al.
Background: Immune checkpoint inhibitors (ICIs) have transformed non-small cell lung cancer (NSCLC) treatment, yet low response rates and resistance remain challenges. Emerging evidence suggests acupuncture may enhance IC...
Buyang Huanwu Decoction enhances hippocampal-cortical connectivity remodeling via sonic hedgehog signaling to ameliorate memory dysfunction in cerebral ischemic rats [0.03%]
补阳还五汤通过声波刺猬信号转导促进脑缺血再灌注损伤大鼠海马-皮层连接重塑及改善学习记忆能力
Yun Lu,Ziyue Lin,Hanyu Wang et al.
Yun Lu et al.
Background: Although Buyang Huanwu Decoction (BHD) has been shown to promote functional recovery of memory following ischemic stroke, the precise mechanisms underlying its therapeutic effects remain incompletely understoo...
Multi-omics reveals mechanism of Qi-Po-Sheng-Mai granule in reducing atrial fibrillation susceptibility in aged rats [0.03%]
多组学揭示益气补阳生脉颗粒减少衰老大鼠房颤易感性的机制
Shuqing Shi,Xiaohan Zhang,Jiayu Lv et al.
Shuqing Shi et al.
Background: Atrial Fibrillation (AF) is the most common arrhythmia in clinical practice, and age is an independent risk factor for the development of AF. Qi-Po-Sheng-Mai granule (QPSM) has been used clinically to treat ag...
Potential of phytochemicals in the treatment of Alzheimer disease by modulating lysosomal dysfunction: a systematic review [0.03%]
植物化学物质通过调节溶酶体功能治疗阿尔茨海默病的潜力：系统性综述
Man Yuan,Trinh Thach Thi Nguyen,Alasdair J Gibb et al.
Man Yuan et al.
Alzheimer disease (AD) is a primary international health dilemma, especially in elderly populations, due to its progressive nature and its adverse cognitive impact. The dysfunction of lysosomes, which impairs protein degradation and leads t...
Integrated metabolomics and the microbiome reveal the compatibility mechanism of the Suxiao Jiuxin pill in the treatment of stable coronary artery disease [0.03%]
整合代谢组学和微生物组揭示苏氏九味丸治疗稳定性冠心病的兼容机制
Wanqi Le,Jingyu Liao,Yuhao Zhang et al.
Wanqi Le et al.
Background: The Suxiao Jiuxin pill (SJP) is a Chinese patent medicine that is used for the treatment of stable coronary artery disease (SCAD). However, the compatibility mechanism of SJP in treating of SCAD is still uncle...
Houttuynia cordata Thunb-derived extracellular vesicle-like particles alleviate ischemic brain injury by miR159a targeting ACSL4 to suppress ferroptosis [0.03%]
鱼腥草外泌体类似微粒通过内源性miR159a靶向ACSL4抑制铁死亡从而减轻缺血脑损伤
ShenYang Zhang,ZhiYan Liang,ChunYi Wu et al.
ShenYang Zhang et al.
Introduction: Neuroprotective agents for acute ischemic stroke often fall short in efficacy due to the blood-brain barrier challenges, lack of target specificity, and limited effectiveness. Recently, plant-derived extrace...
Astrocyte inhibition and PV interneuron activation: key mechanisms in electroacupuncture's effect on pain-anxiety comorbidity [0.03%]
astrocyte抑制和PV间神经元激活：电针镇痛抗焦虑效应的关键机制
Junfan Fang,Yashuang Xu,Mengting Qiu et al.
Junfan Fang et al.
Background: Evidence indicates that the interplay between pain and anxiety poses clinical challenges for the evaluation and management of chronic pain, yet effective therapies for these comorbidities are limited. This stu...
Exploring the potential bioactive compounds group and mechanism of Ci Bai Capsule in treating leukopenia: a combined approach of network pharmacology and transcriptome evidences [0.03%]
基于网络药理学和转录组证据的Ci Bai胶囊治疗白细胞减少症活性成分群及机制研究
Dingfan Zhang,Congshu Huang,Lei Zhou et al.
Dingfan Zhang et al.
Background: Radiation-induced leukopenia caused by low-dose exposure is frequently associated with Traditional Chinese Medicine (TCM) syndromes like "blood deficiency" and "fatigue syndrome". Ci Bai Capsule (CB) has been ...