Synergistic potential of Berberine and Wogonin improved adipose inflammation and insulin resistance associated with obesity through HIF-α axis [0.03%]
小檗碱和黄芩素通过HIF-α轴改善肥胖相关性脂肪组织炎症和胰岛素抵抗的协同潜力
Zihan Zhou,Mingsu Wang,Xiaoyu Zhang et al.
Zihan Zhou et al.
Background: Obesity-induced adipose hypoxia activates the hypoxia-inducible factor alpha (HIF-α) axis, where HIF-1α and HIF-2α exhibit functional antagonism: HIF-1α exacerbates insulin resistance (IR) and inflammation...
Synergistic potential of Berberine and Wogonin improved adipose inflammation and insulin resistance associated with obesity through HIF-α axis [0.03%]
小檗碱和黄芩素通过缺氧诱导因子-α轴改善肥胖相关脂肪组织炎症和胰岛素抵抗的协同潜力
Zihan Zhou,Mingsu Wang,Xiaoyu Zhang et al.
Zihan Zhou et al.
Background: Obesity-induced adipose hypoxia activates the hypoxia-inducible factor alpha (HIF-α) axis, where HIF-1α and HIF-2α exhibit functional antagonism: HIF-1α exacerbates insulin resistance (IR) and inflammation...
Integration of network pharmacology, transcriptomics and single-cell sequencing to explore the effect of Rougan Keli in alleviating liver cirrhosis [0.03%]
整合网络药理学、转录组和单细胞测序研究 rougan keli 缓解肝硬化的作用
Chengbo Jin,Tianle Ma,Yiheng Zhang et al.
Chengbo Jin et al.
Background: The progression of liver cirrhosis leads to severe complications, significantly threatening the survival and prognosis of patients. Rou gan keli (Rgkl), a herbal formula derived from classical prescriptions, h...
Integration of network pharmacology, transcriptomics and single-cell sequencing to explore the effect of Rougan Keli in alleviating liver cirrhosis [0.03%]
整合网络药理学、转录组和单细胞测序研究 Roo Gan Ke Li 改善肝硬化的机制研究
Chengbo Jin,Tianle Ma,Yiheng Zhang et al.
Chengbo Jin et al.
Background: The progression of liver cirrhosis leads to severe complications, significantly threatening the survival and prognosis of patients. Rou gan keli (Rgkl), a herbal formula derived from classical prescriptions, h...
Amygdalin regulated vasoactive intestinal peptide receptor to protect alveolar epithelial barrier against lung injury induced by influenza a virus [0.03%]
苦杏仁苷通过调控肺泡上皮细胞VIP信号通路保护呼吸道上皮屏障功能以抵御甲型流感病毒感染所致的急性肺损伤的作用及机制研究
Xueyue Song,Ting Wang,Miao Ye et al.
Xueyue Song et al.
Background: Bitter apricot kernel is a common traditional Chinese medicine used for lung diseases. Previous studies showed that Xuanbai-Chengqi decoction (XCD) containing bitter apricot kernel protected the alveolar and i...
Isolinderalactone regulates macrophage polarization and efferocytosis by activating the LXRα pathway against ulcerative colitis [0.03%]
孤立菌乳香酸通过激活LXRα途径调节巨噬细胞极化和摄取死亡细胞作用于溃疡性结肠炎
Mincong Huang,Mengyao Lan,Xin Liu et al.
Mincong Huang et al.
Background: Ulcerative colitis (UC), a chronic inflammatory bowel disease, remains an unmet medical need. Lindera aggregata, a traditional Chinese medicine used in treating gastrointestinal disorders, has demonstrated ant...
Xiaoyaosan modulates gut-brain metabolic pathways and brain microstructure in depression: a multi-omics insight [0.03%]
逍遥散调节抑郁症的肠脑代谢途径和脑微结构：多组学洞察
Wen-Zhi Hao,Yan-Ru Sun,Ying-Ren Zhang et al.
Wen-Zhi Hao et al.
Background: Depression is closely associated with metabolic disorders in the gut-brain axis. Our previous studies using antibiotics (ABX)-treated mice and germ-free mice models demonstrated that Xiaoyaosan (XYS) alleviate...
Berberine-based strategies: novel delivery systems bring out new potential for wound healing [0.03%]
基于小檗碱的伤口愈合策略：新型递送系统揭示其潜在作用机制
Jie Yin,Siqi Qin,Junren Chen et al.
Jie Yin et al.
Wound healing is a highly regulated biological process that restores tissue integrity following injury, while it could be disrupted in specific conditions such as diabetes mellitus (DM) and bacterial infection, leading to delayed healing an...
Artemisia annua-derived extracellular vesicles reprogram breast tumor immune microenvironment via altering macrophage polarization and synergizing recruitment of T lymphocytes [0.03%]
青蒿素衍生的细胞外囊泡通过改变巨噬细胞极化和协同募集T淋巴细胞重新编程乳腺肿瘤免疫微环境
Yun Wang,Lin Meng,Sicheng Su et al.
Yun Wang et al.
Background: The immunosuppressive microenvironment and limited immune cell infiltration into the tumor bed contribute to the proliferation, metastasis, and invasion of breast cancer (BC) cells. Reprogramming the tumor imm...
Salvianolic acid B and Senkyunolide I synergistically alleviate cardiac hypertrophy and regulate MAP3K1 signaling [0.03%]
天冬酸乙酯和当药内酯通过协同抑制MAP3K1信号通路缓解心室重构
Changtong Liu,Rui Guo,Yue Zhou et al.
Changtong Liu et al.
Background: Cardiac hypertrophy, characterized by the thickening of the heart muscle, arises from factors such as hypertension and genetic mutations, often leading to adverse outcomes like heart failure and arrhythmias. G...