Unveiling medication patterns in traditional Chinese medicine for the prevention of colorectal cancer recurrence: from potential combinations to validation of components and targets [0.03%]
基于中医古籍的防复方抗癌模式探索研究：从经方拆解组合到组分及靶点验证
Qianqian Bu,Shaoxun Yuan,Xiaoman Wei et al.
Qianqian Bu et al.
Colorectal cancer (CRC) is a prevalent malignant tumor with high incidence and mortality rates, with recurrence being the primary cause of death among patients. Traditional Chinese Medicine (TCM) utilizes a holistic cognitive approach to de...
Gambogic acid induces cell death via covalent binding with PRDX1 to regulate ER stress and autophagy [0.03%]
gambogic酸通过与prdx1共价结合诱导细胞死亡以调节内质网应激和自噬
Jinyan Wang,Wei Zhang,Li Yang et al.
Jinyan Wang et al.
Background: Gambogic acid (GA) is a natural bioactive compound derived from Garcinia hanburyi Hook. F, has proven anticancer activity and is currently in Phase II clinical trials for the treatment of cancer. However, the ...
Metapath2vec and attention-driven heterogeneous graph learning for prioritizing TCM-derived small molecules in gastric cancer [0.03%]
基于元路径的TCM派生的小分子抗胃癌潜力预测模型研究
Nengquan Sheng,Jinran Liu,Wen Fang et al.
Nengquan Sheng et al.
Traditional Chinese Medicine (TCM) represents a multi-component therapeutic system with substantial chemical complexity. This complexity makes it difficult to directly elucidate anti-gastric cancer mechanisms from macroscopic herbal formula...
A clinical and mechanistic study on traditional Chinese medicine herbs used in olfactory training [0.03%]
临床和机制研究：中药嗅觉训练疗法
Wei Zhang,Yingjian Liu,Jiahui Sun et al.
Wei Zhang et al.
Background: Olfactory dysfunction (OD) is a prevalent condition with limited treatment options, severely impairing patients' quality of life. Olfactory training (OT) using conventional odorants provides limited benefit. T...
Ureic clearance granule ameliorates chronic kidney disease by reshaping microbial dysbiosis via modulating bile acid metabolism [0.03%]
尿素清理颗粒通过调节胆汁酸代谢重塑肠道菌群失调以改善慢性肾脏病
Li-Min Liu,Yu-Lu Zhang,Jing-Teng Zhou et al.
Li-Min Liu et al.
Background: Chronic kidney disease (CKD) is a highly prevalent global public health problem that inevitably leads to renal failure. Although renin-angiotensin system blockers, as first-line therapy, can reduce proteinuria...
Huayu-qutan formula ameliorates hypertrophic cardiomyopathy by regulating MAPK and HIF‑1α-signaling pathways [0.03%]
华瘀清痰方通过调节MAPK和HIF-1α信号通路改善肥厚型心肌病
Wei Ding,Ni Zhang,Lei Xiao et al.
Wei Ding et al.
Background: Hypertrophic cardiomyopathy (HCM) is often complicated by coronary microvascular dysfunction (CMD), which precipitates localized myocardial ischemia and metabolic disturbance, triggering compensatory cardiomyo...
Homo- and hetero-dimeric sesquiterpenoids with unprecedented skeletons and their co-occurring monomers from Vernonia solanifolia with anti-liver steatotic potential [0.03%]
来自 Vernonia solanifolia 具有抗肝脂肪变潜力的同分异构二聚茋衍生物及其共存单体
Yue Yang,Fei Zhou,Chang-Qiang Ke et al.
Yue Yang et al.
Background: Sesquiterpenoids show potential as therapeutics against metabolic dysfunction-associated steatotic liver disease (MASLD). Vernonia solanifolia Benth. has been traditionally used to treat abdominal pain and ent...
Licoisoflavone A potentiates oxaliplatin efficacy in colorectal cancer by dual targeting arginine metabolism of tumor microenvironment and cancer cells [0.03%]
LICoisflavone A通过双重靶向肿瘤微环境和癌细胞的精氨酸代谢增强oxaliplatin治疗结直肠癌的效果
Lu Wang,Qing-Rui Liu,Bing-Wen Zhou et al.
Lu Wang et al.
Background: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality, with resistance to oxaliplatin (Oxa) and its associated side effects posing major therapeutic challenges. Natural flavonoids have sh...
Why the same herb is not the same medicine: plant epigenetic and metabolic plasticity as a missing variable in Chinese medicine [0.03%]
为何同一种草药不是同样的药物：植物表观遗传和代谢可塑性是中医药中缺失的变量
Tae Kyung Hyun
Tae Kyung Hyun
Traditional Chinese medicine (TCM) standardization is largely based on chemical equivalence, yet achieving reproducible therapeutic efficacy remains challenging. This limitation reflects an implicit assumption that medicinal plants are chem...
Celastrol ameliorates atherosclerosis by inhibiting TLR4/STAT3/NLRP3-mediated macrophage pyroptosis [0.03%]
celastrol通过抑制tlr4/stat3/nlrp3介导的巨噬细胞pyroptosis改善动脉粥样硬化
Yaning Shi,Ziyi Li,Qizhi Liu et al.
Yaning Shi et al.
Background: Atherosclerosis is a chronic inflammatory disease characterized by plaque formation. Macrophage pyroptosis critically contributes to the formation and expansion of necrotic core as well as the instability of a...