Skin-Brain Axis: neural pathways in acupuncture treatment [0.03%]
针刺治疗中的皮肤病经颅神经通路机制研究——皮肤-大脑轴的影响因素及作用路径探讨
Teng He,Yuanjia Zheng,Jinglan Yan et al.
Teng He et al.
The "Skin-Brain Axis" hypothesis posits that the skin contains a dense network of nerve endings, neurotransmitters, and neuropeptide receptors capable of detecting tissue damage with high precision and relaying signals to the brain through ...
Electroacupuncture attenuates intestinal epithelial ferroptosis in inflammatory bowel disease via Piezo1-mediated mitochondrial homeostasis [0.03%]
电针通过Piezo1介导的线粒体稳态缓解炎症性肠病中的肠道上皮细胞铁死亡
Haolong He,Jingying Zhou,Sihui Cao et al.
Haolong He et al.
Background: Inflammatory bowel disease (IBD) involves pathological mechanical forces transduced by mechanosensitive Piezo1 channels. While electroacupuncture (EA) alleviates IBD injury, its relationship with Piezo1-mediat...
Epigenetic control of the plant metabolome: implications for Chinese medicine [0.03%]
植物代谢组的表观遗传调控：对中国医学的影响
Tae Kyung Hyun
Tae Kyung Hyun
Epigenetic regulation-including DNA methylation, histone modifications, and small RNAs-plays a crucial role in modulating specialized metabolism in plants; specialized metabolites confer crucial pharmacological properties to plants, forming...
Novel intranasal delivery of sihosogansan demonstrates rapid antidepressant activity via GABAergic and BDNF/TrkB pathways: identification of potential bioactive quality markers [0.03%]
新的鼻内给药sihosogan-san通过GABA能和BDNF/TrkB途径快速抗抑郁作用：潜在生物活性质量标志物的鉴定
Khoa Nguyen Tran,Yeasmin Akter Munni,Ly Thi Huong Nguyen et al.
Khoa Nguyen Tran et al.
Background: Sihosogansan (SHSGS) is a traditional medicine used to treat depression. However, conventional oral administration requires high doses and prolonged treatment periods. This study aimed to investigate the rapid...
Identification of salvianolic acid A as an ADP receptor-selective and Gq/IP3 pathway-mediated anti-platelet component in Qishen Yiqi [0.03%]
基于气相色谱-三重四级杆质谱联用技术的丹参茋类成分诱导人脐静脉内皮细胞差异表达蛋白质的研究
Wenli Dang,Liping Chen,Qinhua Shang et al.
Wenli Dang et al.
Background: Antiplatelet therapy is crucial for preventing and treating cardio-cerebrovascular diseases. However, adverse events related to thrombosis or bleeding have been reported in instances of treatment with glycopro...
Deciphering the antiviral mechanisms of Fangqin Qinggan decoction against influenza A virus: a multi-omics and machine learning approach [0.03%]
方芩清肝汤抗流感病毒机制研究：多组学与机器学习联合分析
Huan Lei,Hao Zhang,Yixi Xu et al.
Huan Lei et al.
Background: Influenza A virus (IAV) infection poses a significant global health burden, contributing to high morbidity and mortality in both humans and animals through rapid viral transmission and dysregulated inflammator...
Inhibition of P2X7 receptor in satellite glial cells contributes to electroacupuncture's analgesia in rats with CFA-induced inflammatory pain [0.03%]
电针镇痛作用依赖于星形胶质细胞P2X7受体的抑制状态
Yuxin Wu,Minghui Wu,Shuxin Tian et al.
Yuxin Wu et al.
Background: Accumulating evidence highlights the anti-inflammatory and analgesic effects of electroacupuncture (EA), yet the underlying mechanisms remain poorly understood. The P2X7 purinergic receptor (P2X7R), located in...
Therapeutic potential of traditional Chinese medicine and mechanisms for the treatment of type 2 diabetes mellitus [0.03%]
中医药治疗2型糖尿病的治疗潜力及作用机制研究
Miao Wang,Qing Yang,Ye Li et al.
Miao Wang et al.
Diabetes, a chronic metabolic non-communicable disease, has become prevalent worldwide. Its prevalence is increasing at an alarming rate, and the affected population is becoming increasingly younger, posing a serious threat to both individu...
Multi-omics and network pharmacology approaches reveal the mechanism of action of KeKe tablet against post-infectious cough [0.03%]
基于多组学和网络药理学的咳可平片治疗感染后咳嗽的作用机制研究
Mengyue Su,Jiahe Zhang,Shukun Wang et al.
Mengyue Su et al.
Background: Post-infectious cough (PIC) refers to a persistent cough lasting longer than three consecutive weeks following an infection, despite the resolution of other symptoms and normal examination results. This common...
Feasibility of vinegar processing of toxic herbs in Shi-Zao-Tang: toxicity reduction, efficacy preservation in malignant ascites rats and underlying pharmacodynamic mechanisms [0.03%]
丹参素对醋制十枣汤解毒、保效及机制研究
Jin-Di Xu,Xiao-Qin Gao,Rong-Ling Zhong et al.
Jin-Di Xu et al.
Background: Shi-Zao-Tang (SZT), a classical formula of Traditional Chinese Medicine orally used for treating malignant ascites effusion (MAE), is made by mixing the powder of Kansui Radix (KR), Euphorbiae Pekinensis Radix...