Functional near-infrared spectroscopy (fNIRS) in medical research: applications, opportunities, and challenges [0.03%]
功能近红外光谱(fNIRS)在医学研究中的应用、机遇和挑战
Qingya Yu,Qiuxu Yuan,Yuying Song et al.
Qingya Yu et al.
fNIRS is an innovative and non-invasive tool for monitoring hemodynamic changes in the cerebral cortex. In recent years, it has become a widely used intervention method in the medical field for treating various diseases due to its portabili...
Dachaihu decoction alleviates septic liver injury by modulating the intestinal barrier dysfunction and suppressing the NF-κB/NLRP3/Caspase-1 signaling pathway [0.03%]
大柴胡汤通过调节肠道屏障功能障碍并抑制NF-κB/NLRP3/Caspase-1信号通路缓解脓毒症肝损伤
Zhen Yang,Xingyu Kao,Lin Zhang et al.
Zhen Yang et al.
Background: Intestinal barrier dysfunction is a key driver of septic liver injury (SLI). Dachaihu decoction (DCHD), a classic traditional Chinese medicine formula recorded in the Treatise on Cold Damage, is widely used to...
Heterophyllin B ameliorates diabetic lower limb ischemia by inhibiting SMOX to activate the Nrf2 antioxidant pathway [0.03%]
异叶茋B通过抑制SMOX激活Nrf2抗氧化途径改善糖尿病下肢缺血
Shudong Lin,Yunchao Huang,Yiqiong Wang et al.
Shudong Lin et al.
Background: Diabetic lower limb ischemia (DLLI) is a serious complication of diabetes with limited therapeutic options. Heterophyllin B (HET-B), a bioactive cyclopeptide from Pseudostellaria heterophylla, possesses antiox...
Processing-induced detoxification of toxic Traditional Chinese Medicines: a systematic review of attenuation mechanisms at physical, chemical, and in vivo levels [0.03%]
有毒中药的炮制解毒作用：物理、化学及生物活性水平减轻毒性的机制系统综述
Weiye Zhang,Zhubin Zhang,Ziwen Bian et al.
Weiye Zhang et al.
The "toxicity" of Traditional Chinese Medicines (TCMs) carries a dual connotation, referring both to the potent nature of certain medicinal substances and a critical constraint on their safe clinical application. Processing is the core appr...
Polygala oligosaccharide esters improve memory disorder by restoring gut microbiota homeostasis through the regulation of the "gut-brain" axis [0.03%]
聚花灵多糖酯通过调控“肠-脑轴”恢复肠道菌群稳态从而改善认知障碍
Yan Wang,Chaoyun Ren,Wenkai Dong et al.
Yan Wang et al.
Background: Yuanzhi (Polygala tenuifolia Willd.) possesses the effects of calming the spirit, enhancing intelligence, regulating the heart-kidney connection, eliminating phlegm, and reducing swelling. It is commonly used ...
Application of biosensors in research of traditional Chinese medicine: a systematic review [0.03%]
生物传感器在中医药研究中的应用：系统综述
Shengnan Du,Fan Zhang,Xing Yan et al.
Shengnan Du et al.
As advanced analytical tools, biosensors combine biological recognition elements with physicochemical transducers, enabling the sensitive and selective detection of target analytes. As research in traditional Chinese medicine (TCM) continue...
Chuangling Ye mitigates diabetic foot ulcer through suppressing keratinocyte ferroptosis via inhibiting ACSS2/ACSL4 axis [0.03%]
叶创灵通过抑制ACSS2/ACSL4轴抑制角质细胞铁死亡从而治疗糖尿病足溃疡
Xiao Feng,Nan Yi,Cunyu Zhang et al.
Xiao Feng et al.
Background: Diabetic foot ulcers (DFU) is a serious complication of diabetes, and keratinocyte ferroptosis has been shown to accelerate its pathological progression. Chuanglin Ye (CLY), widely used in clinical practice fo...
Calculus Bovis ameliorates primary sclerosing cholangitis via a dual-pronged mechanism restoring bile acid and lipid homeostasis in the gut-liver axis [0.03%]
牛黄通过肠道-肝脏轴的双重机制恢复胆汁酸和脂质稳态从而改善原发性硬化性胆管炎
Xuepeng Gong,Yufei Chen,Tinghui Zhao et al.
Xuepeng Gong et al.
Objective: Primary sclerosing cholangitis (PSC) is a progressive cholestatic liver disease lacking FDA-approved therapy. Calculus Bovis (CB), a traditional medicine derived from animal gallstones, has been historically us...
Hyperoside protects against poly-GR-mediated neurodegeneration via regulation of mitochondrial fission and oxidative stress in C9orf72-associated ALS [0.03%]
富柳苷通过调节C9orf72基因相关ALS中线粒体分裂和氧化应激来对抗多聚体poly-GR介导的神经退行性病变
Wen-Chi Hsieh,Chun-Yu Lin,Hsuan-Cheng Wu et al.
Wen-Chi Hsieh et al.
Background: Arginine-rich poly-glycine-arginine (poly-GR), a toxic dipeptide repeat protein generated from C9orf72 hexanucleotide repeat expansion, drives mitochondrial dysfunction, oxidative stress, and neuronal loss in ...
An integrated machine learning framework for TCM five-flavor classification based on E-tongue profiling and SHAP analysis [0.03%]
基于E舌谱和SHAP分析的中药五味性整合机器学习框架
Ziang Li,Xianglong Meng,Lin Yang et al.
Ziang Li et al.
Background: The "five-flavor" (wu wei) classification is a core organizing principle in Traditional Chinese Medicine (TCM) pharmacology and quality control, yet its assessment still relies on subjective organoleptic evalu...