Dendrobine ameliorates mitophagy-mediated endothelial senescence in diabetic kidney disease through activating the SIRT1/FOXO3a pathway [0.03%]
石斛素通过激活SIRT1/FOXO3a途径改善糖尿病肾病内皮细胞线粒体自噬介导的衰老
Yan Zhang,Xuan Qi,Rui-Xuan Sun et al.
Yan Zhang et al.
Background: Glomerular senescence plays a vital role in the pathogenesis of diabetic kidney disease (DKD). Dendrobine (Den) exhibits anti-senescence properties and nephroprotective effects; however, its precise impact and...
Mechanistic insights into the multi-target anti-atherosclerotic actions of rhubarb: a traditional remedy revisited [0.03%]
药用大黄抗动脉粥样硬化多靶点机制研究的新认识
Feng-Jiao Hu,Yue-Ming Tang,Bin-Yue Hu et al.
Feng-Jiao Hu et al.
Atherosclerosis (AS), a chronic inflammatory vascular disease, underlies the pathogenesis of most cardiovascular disorders. Its pathologic features include endothelial damage, inflammatory response, lipid plaque formation and rupture, throm...
Exocarpium Citri Grandis ameliorates alcoholic liver disease by modulation of hepatic lipid metabolism and iron homeostasis [0.03%]
瓜蒌皮通过调节肝脂代谢和铁稳态治疗酒精性肝病
Yun-Jia Li,Yu-Xue Zhang,Shu Xu et al.
Yun-Jia Li et al.
Background: Alcoholic liver disease (ALD) is a key cause of chronic liver disease worldwide, which progresses to liver cirrhosis and even hepatocellular carcinoma. After years of application and research, the traditional ...
Omics-based profiling and therapeutic potential of natural components in pan-Shennongjia medicinal herbs [0.03%]
基于组学的神农架全域药用植物活性成分功效评价及开发利用潜力研究
Jun Song,Chong Yuan,Fei Wang et al.
Jun Song et al.
The pan-Shennongjia region represents a globally significant biodiversity hotspot characterized by high species diversity and endemism. While its rich medicinal resources have long been recognized, the systematic characterization of their n...
Traditional Chinese medicine use and risk of type 2 diabetes mellitus among patients with prediabetes: a population-based cohort study [0.03%]
基于人群的队列研究中糖尿病前期患者使用中药与2型糖尿病风险的关系
Zilin Long,Houyu Zhao,Yueqi Yin et al.
Zilin Long et al.
Background: Prediabetes was a reversible process in the development of type 2 diabetes mellitus (T2DM). Traditional Chinese medicine (TCM) was used to regulate blood glucose for thousands of years. However, there was a la...
Integrating knowledge graphs with ancient Chinese medicine classics: challenges and future prospects of multi-agent system convergence [0.03%]
知识图谱与中医古籍的融合：多Agent系统汇聚的挑战和未来展望
Shate Xiang,Huanxiang Lin,Fen Cai et al.
Shate Xiang et al.
The inheritance of knowledge from Ancient Chinese Medicine Classics (ACMC) confronts challenges including fragmented literature, terminological heterogeneity, and reliance on traditional apprenticeship. Knowledge Graphs (KG) have become one...
5,7-dimethoxyflavone inhibits hepatocellular carcinoma progression via increasing intestinal Akkermansia muciniphila and hepatic CD8+ T cell infiltration [0.03%]
5,7-二甲氧基黄酮通过增加肠道Akk菌和肝部CD8+T细胞浸润抑制肝癌进展
Weicong Chen,Changshun Liu,Xiao Li et al.
Weicong Chen et al.
Background: Hepatocellular carcinoma (HCC) mainly develops in cases of fibrosis and cirrhosis and is accompanied by intestinal flora disorder. HCC also affects CD8+ T cell immune function. 5,7-Dimethoxyflavone (DMF), an a...
Comparative analysis of Chinese classical prescriptions and global traditional polyherbal formulations: insights from the database of global polyherbal formulation (GPFD) [0.03%]
基于全球复方数据库的中药经典名方与国际传统复方比较分析研究
Hongguo Chen,Zhaoyu Liu,Yupeng Du et al.
Hongguo Chen et al.
Polyherbal formulations (PHFs) serve as a cornerstone of traditional medical systems worldwide and remain integral to diverse therapeutic practices. The COVID-19 pandemic has reinvigorated scientific interest in PHFs, driving extensive inve...
Potential mechanisms of acupuncture treatment for rheumatoid arthritis: a study based on network topology and machine learning [0.03%]
基于网络拓扑和机器学习的针刺治疗类风湿性关节炎潜在机制研究
Feiyang Li,Zhen Liu,Yuan Xu et al.
Feiyang Li et al.
Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease that requires multitarget therapeutic strategies. Acupuncture, an integrative therapy of traditional Chinese medicine (TCM), has shown efficacy in the...
Discovery of an AKT1-targeting compound from a traditional herbal formula for alcoholic liver disease via integrative computational and experimental approaches [0.03%]
通过整合计算和实验方法发现治疗酒精性肝病的传统草药方中针对AKT1的化合物
Shuxuan Yang,Caiting Zou,Dexian Li et al.
Shuxuan Yang et al.
Background: Alcoholic liver disease (ALD) poses a major global health challenge, with limited effective interventions. The Dampness-Heat Regulating Formula (DRF), a traditional Chinese herbal tea composed of nine edible m...