Shengxian decoction suppresses malignant progression of lung adenocarcinoma by enhancing CD8+ T cell function via the FYN-PI3K/AKT axis [0.03%]
圣贤汤通过FYN-PI3K/AKT轴增强CD8+t细胞功能抑制肺腺癌恶性进展
Qiong Ma,Xiao Zeng,Chunxia Huang et al.
Qiong Ma et al.
Background: Shengxian Decoction (SXD), a traditional Chinese herbal formula, has demonstrated significant clinical efficacy against lung adenocarcinoma (LUAD). However, its exact mechanisms of action remain to be elucidat...
A systems herbal-to-molecule and transcriptomic strategy identifies emodin as an ESR1-targeting phytochemical driving thrombopoiesis [0.03%]
一种中药到分子和转录组策略识别出大黄素是一种驱动巨核细胞生成的ESR1靶向植物化学物质
Xiao Qi,Qinyao Li,Fengyu Li et al.
Xiao Qi et al.
Radiation-induced thrombocytopenia (RIT) is a major dose-limiting toxicity of radiotherapy, for which effective pharmacological interventions remain limited. Rhei Radix et Rhizoma (RR) is widely used in traditional medicine, yet its thrombo...
Wubi Shanyao Pills ameliorate glucocorticoid-induced osteoporosis by regulating bone marrow T cell homing as an immune intermediate to restore bone metabolism [0.03%]
乌威湿山药丸通过调节骨髓T细胞归巢免疫介体来改善糖皮质激素引起的骨质疏松症以恢复骨代谢
Ying-Jie Dong,Jia-Yue Zhu,Jie Su et al.
Ying-Jie Dong et al.
Background: The disruption of bone immune function and bone metabolism homeostasis is intricately linked to the onset and progression of glucocorticoid-induced osteoporosis (GIOP). From the perspective of indirect pharmac...
Pro-EGCG suppresses endometriosis progression via regulating monocytic myeloid-derived suppressor cells [0.03%]
普_egcg通过调节单核来源的髓系抑制细胞来抑制子宫内膜异位症的发展
Qianhan Xu,Lu Chen,Jun Chen et al.
Qianhan Xu et al.
Background: Pro-EGCG has shown therapeutic promise for endometriosis, yet its immunoregulatory mechanisms remain unclear. Myeloid-derived suppressor cells (MDSCs) are key drivers of disease progression. This study investi...
The IL-17A modulating astrocytic activity was associated with the electroacupuncture-mediated improvement of sensorimotor ability after stroke [0.03%]
电针改善卒中后感觉运动功能缺损与星形胶质细胞介导的IL-17A活性下调有关
Yuenming Yau,Zeli Li,Zhiyuan Jiang et al.
Yuenming Yau et al.
Both clinical and preclinical evidence showed that electroacupuncture (EA) at Baihui (Governing Vessel 20, GV20) and Dazhui (GV14) could relieve sensorimotor disability after ischemic stroke (IS). However, the mechanism behind this therapeu...
Jiedu Huoxue decoction inhibits cardiomyocyte apoptosis via PTEN/AKT/GSK3β-mediated mitochondrial dynamics in myocardial infarction: an integrative study of network pharmacology, transcriptomics and molecular docking [0.03%]
解毒活血汤通过PTEN/AKT/GSK3β介导的线粒体动力学抑制心肌梗死心脏成纤维细胞凋亡：网络药理学、转录组学和分子对接综合研究
Mingjie Pang,Han Peng,Changlei Hu et al.
Mingjie Pang et al.
Background: Myocardial infarction (MI) triggers oxidative stress, mitochondrial dysfunction, and cardiomyocyte apoptosis. At present, it remains urgently needed to develop novel therapies specifically suppressing cardiomy...
Herb-derived immunometabolic modulators: traditional Chinese medicine at the crossroads of metabolism and antitumor immunity [0.03%]
源自草药的免疫代谢调节剂：传统中医在代谢和抗肿瘤免疫的交汇点
Bo Zhang,Na Wang,Xiaoshan Wang et al.
Bo Zhang et al.
Background: Traditional Chinese Medicine (TCM) has long been applied in oncology to "support vital Qi and eliminate pathogenic factors", yet its place within modern immunometabolic therapy is still not clearly defined. Tu...
Paishi granule inhibits calcium oxalate-induced oxidative stress kidney injury after gut microbiota transformation: a multi-omics analysis combined in vivo and in vitro study [0.03%]
基于多组学联合体内外研究的排石颗粒通过改造肠道菌群抑制草酸钙所致氧化应激肾损伤作用机制探讨
Bingqi Zhang,Xingxu Pan,Xiaolin Xie et al.
Bingqi Zhang et al.
Background: Renal stones are a common clinical problem with a high recurrence rate. In recent years, many Chinese herbs have been reported to effectively ameliorate calcium oxalate via different mechanisms. Gut microbiota...
Panax quinquefolium saponin decreases atherosclerosis in ovariectomized ApoE-/- mice via regulating estrogen receptor α [0.03%]
五味子皂苷通过调节雌激素受体α降低卵巢切除ApoE基因敲除小鼠动脉粥样硬化水平
Li Chen,Jun-He Shi,Xiao-Juan Ma et al.
Li Chen et al.
Background: Postmenopausal women are at an increased risk for atherogenesis. Panax quinquefolium saponin (PQS) has demonstrated beneficial effects on decreasing inflammatory response, alleviating oxidative stress and impr...
Critical role of high-dose Astragalus in Buyang Huanwu Decoction for enhancing neurovascular coupling in a Qi Deficiency and Blood Stasis animal model [0.03%]
黄芪重用量参附益气汤通过改善气虚血瘀动物模型的神经血管耦合发挥作用的关键作用机制研究
Kaichao Hu,Juxiang Yang,Guining Wei et al.
Kaichao Hu et al.
Background: Buyang Huanwu Decoction (BHD) is a classical Traditional Chinese Medicine (TCM) formula effective for treating Chronic Cerebral Ischemia with Qi Deficiency and Blood Stasis Syndrome (CCIQDBS), which is known t...