Biomimetic nanodelivery system with simultaneous blood-brain barrier-crossing and neuroprotective abilities for anti-parkinsonian therapy [0.03%]
一种用于抗帕金森病治疗的同时具备血脑屏障穿越和神经保护能力的仿生纳米递送系统
Xuanying Yin,Jinmei Qiu,Guowang Cheng et al.
Xuanying Yin et al.
Background: Parkinson's disease (PD) has emerged as a critical public health challenge amidst global population aging. The pathogenesis of PD is extremely complex. Notably, evidence showed that neuroinflammation due to mi...
Serum IgG N-glycans act as serum biomarkers for differentiation of cold and heat pattern in rheumatoid arthritis [0.03%]
血清IgG糖链作为区分类风湿关节炎寒热证型的生物标志物
Yilin Wang,Yu Lai,Jingrong Wang et al.
Yilin Wang et al.
Background: To develop and validate a panel of serum IgG N-glycan biomarkers for both the diagnosis of rheumatoid arthritis (RA) and the differentiation of Traditional Chinese Medicine (TCM) syndromes in RA patients. ...
Dendrobine alleviates CCl4-induced acute liver injury by inhibiting necroptosis through activation of the Nrf2/PPARγ/SOD2 signaling pathways [0.03%]
石斛素通过激活Nrf2/PPARγ/SOD2信号通路抑制坏死性凋亡从而改善四氯化碳诱导的急性肝损伤
Yonggang Yang,Xiaolong Fu,Ling Tan et al.
Yonggang Yang et al.
Background: Acute liver injury (ALI) represents a critical clinical challenge characterized by rapid degradation of hepatic function, necessitating prompt intervention for improved patient outcomes. Dendrobine (DDB) is th...
Yiqi Wenyang Formula ameliorates diabetic kidney disease via inhibiting inflammation and regulating the gut microbiota-bile acid axis in mice by FXR signaling pathway [0.03%]
一气温阳方通过抑制炎症及调节肠道菌群-胆汁酸轴FXR信号通路改善小鼠糖尿病肾病作用机制研究
Tongyi Yuan,Xiang Gao,Xinxin Wang et al.
Tongyi Yuan et al.
Background: Diabetic kidney disease (DKD) is a microangiopathic complication of diabetes. Yiqi Wenyang Formula (YQWYF) has been used to treat DKD in the clinic for many years. However, the underlying regulatory mechanisms...
Liriodendron attenuates intestinal fibrosis and inflammation in mice with radiation proctopathy [0.03%]
黄莲木对放射性直肠病模型小鼠肠道纤维化和炎症的改善作用研究
Hao Huang,Junsheng Li,Yanling Zhang et al.
Hao Huang et al.
Radiotherapy (RT) is a commonly employed therapeutic approach for malignant tumors located in the abdomen. However, radiation proctopathy (RP) is a significant side effect that occurs during RT, and there are limited pharmaceutical interven...
HuoXue QianYang QuTan recipe attenuates myocardial hypertrophy in obese hypertensive rats by regulating MPC1/MCT4 mediated pyruvate-lactate metabolic axis [0.03%]
祛痰活血前贤曲通过调控MPC1/MCT4介导的丙酮酸-乳酸代谢轴抑制肥胖高血压大鼠心室重构的作用机制研究
Jing Wang,Meng Wang,Jianhua Li et al.
Jing Wang et al.
Background: HuoXue QianYang QuTan Recipe (HQQR) is an effective prescription for the clinical management of myocardial hypertrophy in patients with obesity-related hypertension (OBH). In previous studies, HQQR showed the ...
Huang-Lian-Jie-Du decoction alleviates cognitive impairment in periodontitis rats through restoring microbiota-gut-brain axis and inhibiting neuroinflammation via TLR4/NF-κB pathway [0.03%]
黄连解毒汤通过重塑微生态-肠-脑轴及TLR4/NF-κB信号通路抑制神经炎症缓解牙周病大鼠认知障碍
Mingqi Chen,Jie Li,Pan Ren et al.
Mingqi Chen et al.
Background: Huang-Lian-Jie-Du decoction (HLJDD), a typical formulation for heat clearance and detoxification, shows therapeutic potential for oral diseases and cognitive impairment. Nevertheless, the mechanism by which HL...
Ershen Dan attenuates atherosclerosis by modulating the NOTCH1/NF-κB/NLRP3 signaling pathway to suppress M1 macrophage polarization [0.03%]
尔甚丹通过调控NOTCH1/NF-κB/NLRP3信号通路抑制M1型巨噬细胞极化以缓解动脉粥样硬化病情
Wenjie Zhao,Hui Wang,Shijing Peng et al.
Wenjie Zhao et al.
Background: Atherosclerosis is a chronic inflammatory disease. Inhibition of macrophage inflammatory secretion is the key to the prevention and treatment of atherosclerosis. Ershen Dan (ESD) has been shown to be effective...
Detumescence Analgesic Plaster mitigates knee osteoarthritis via active ingredients targeting mitochondrial complex 1/AMPK/MYL3-regulated cartilage homeostasis [0.03%]
退潜止痛膏通过活性成分靶向线粒体复合物1/AMPK/MYL3调节软骨稳态缓解膝关节炎
Chunxia Li,Weijie Li,Yue Yin et al.
Chunxia Li et al.
Background: The Detumescence Analgesic Plaster (DAP) has been widely used in clinical practice for knee osteoarthritis (KOA) treatment, yet its active ingredients and molecular mechanisms remain incompletely understood. ...
Qing-Kai-Ling oral liquid alleviates non-alcoholic fatty liver disease via remodeling gut microbiota and activating AMPK/ACC1 axis [0.03%]
清凯灵口服液通过重塑肠道菌群和激活AMPK/ACC1轴改善非酒精性脂肪肝病
Kaiwei Cai,Zihao Chen,Jingyun Wu et al.
Kaiwei Cai et al.
Background: Qing-Kai-Ling (QKL) oral liquid, evolving from a classical Chinese formula known as An-Gong-Niu-Huang pills, has demonstrated hepatoprotective, lung-protective, and gut microbiota-modulating properties. Howeve...