Beyond transparency: why Traditional Chinese Medicine (TCM) need explainable artificial intelligence (XAI) [0.03%]
超越透明度：中医为何需要可解释的人工智能(XAI)
Wanting Zheng,Yuanyuan Tong,Jinjian Huang et al.
Wanting Zheng et al.
The integration of artificial intelligence (AI) with Traditional Chinese Medicine (TCM) is rapidly expanding, creating new opportunities for digital diagnosis, syndrome differentiation, prescription recommendation, multimodal clinical suppo...
Natural polysaccharides targeting mitochondrial function for colorectal cancer prevention and treatment: mechanisms and nano-delivery strategies [0.03%]
针对肠道肿瘤预防和治疗的天然多糖类线粒体功能调节药物的作用机制及纳米传递策略研究进展
Huan Yan,Lianfeng Wang,Jiaxin Gan et al.
Huan Yan et al.
Background: Colorectal cancer (CRC) is a malignant tumor of the digestive system with high incidence and mortality worldwide. Mitochondrial dysfunction plays a central role in the development, progression, and chemotherap...
Renqing Mangjue modulates chronic atrophic gastritis inflammation-cancer transition via the cGMP-PKG/PI3K-AKT pathway [0.03%]
仁青芒觉通过环磷酸鸟苷-蛋白激酶G/磷脂酰肌醇-3-激酶-蛋白激酶B信号轴调控慢性萎缩性胃炎炎癌转化作用机制研究
Fengyu Huang,Peiping Chen,Daiyue Ding et al.
Fengyu Huang et al.
Background: Chronic atrophic gastritis (CAG) is a critical stage in the progression from inflammation to cancer and is closely associated with an increased risk of gastric cancer (GC). Renqing Mangjue (RQMJ), a traditiona...
Rhein from a traditional herbal formula attenuates hepatic fibrosis via ALDH1A3-mediated retinoic acid metabolism [0.03%]
Rhein通过ALDH1A3介导的代谢调节肝纤维化中的视黄酸机制
Kai Yu,Minqi Chen,Wanchao Hou et al.
Kai Yu et al.
Background: Hepatic fibrosis is a prevalent outcome of chronic liver diseases. Although activation of hepatic stellate cell (HSC) is a primary driver of fibrogenesis, therapeutic strategies targeting retinoic acid (RA) me...
Electroacupuncture enhances anti-tumor immunity in TNBC by reducing NE release and blocking α2-AR-mediated NGF/Hippo signaling [0.03%]
电针可通过减少去甲肾上腺素释放和阻断α2-AR介导的NGF/Hippo信号增强三阴性乳腺癌抗肿瘤免疫能力
Fei-Fei Li,Yan Huang,Chun-Fang Gao et al.
Fei-Fei Li et al.
Background: Targeting the neuro-immune microenvironment to suppress triple-negative breast cancer (TNBC) represents a critical strategy in tumor immunotherapy. ...
Resveratrol-activated PI3K/AKT/mTOR signaling pathway attenuates ferroptosis by promoting NRF2/GPX4 metabolic pathway to mitigate IFN-gamma-mediated aplastic anemia [0.03%]
白藜芦醇通过激活PI3K/AKT/mTOR信号通路缓解γ-干扰素所致再生障碍性贫血：一种新的铁死亡调控机制
Erhao Zhang,Jianan Cui,Xinran Zhu et al.
Erhao Zhang et al.
Background: Aplastic anemia (AA) is a severe hematological disorder caused by hyperactivated T cell-mediated hematopoietic failure. It is characterized by hematopoietic stem cell deficiency and hypocellular hematopoiesis ...
Xifeng Zhichou decoction mitigates tic disorder on juvenile rats by regulating neuroinflammation and neurotransmitter homeostasis: dual modulation of Nr4a2 and gut microbiota [0.03%]
止痉涤稠汤通过调控神经炎症和神经递质稳态缓解青少年期仓鼠抽动障碍：Nr4a2与肠道微生态的双向调节作用机制研究
Ruolan Wu,Jinlan Peng,Mingyue Zhang et al.
Ruolan Wu et al.
Background: Xifeng Zhichou decoction (XFZCD), a modified formulation of Chinese medicine, demonstrates significant clinical efficacy in treatment of tic disorder (TD). However, its efficacy and therapeutic mechanisms rema...
Qishen Granules attenuate adverse ventricular remodeling in chronic heart failure by promoting Legumain/Arg1/Rac1-mediated efferocytosis of resident cardiac macrophages [0.03%]
补肾方通过促进心室驻留巨噬细胞Legumain/Arg1/Rac1介导的促凋亡作用来缓解慢性心力衰竭中不利的心室重塑作用
Meijiao Tao,Shixuan Min,Jiali Liu et al.
Meijiao Tao et al.
Background: Ventricular remodeling is a key pathological feature of chronic heart failure (CHF). Following myocardial infarction (MI), impaired macrophage efferocytosis sustains cardiac inflammation, disrupts tissue repai...
Advances in electroacupuncture for perioperative neurocognitive disorders: mechanisms and clinical evidence [0.03%]
电针改善围手术期神经认知障碍的新进展：机制与临床证据
Shirong Wei,Sitong Zhou,Junwen Tu et al.
Shirong Wei et al.
Perioperative neurocognitive disorders (PND), including postoperative delirium, delayed neurocognitive recovery, and postoperative cognitive dysfunction, are common complications in older surgical patients and are associated with impaired r...
Eerdun Wurile, a Mongolian medicine, alleviates neuronal damage and improves neurological dysfunction after cerebral hemorrhage by activating the PI3K/AKT signaling pathway [0.03%]
厄多 wombug 芪防治脑出血后神经元损伤和改善神经功能缺损的作用及对PI3K/Akt信号通路的影响
Wenhui Yang,Yilu Li,Xueying Wang et al.
Wenhui Yang et al.
Background: This study aims to evaluate the neuroprotective effects of the Mongolian medicine Eerdun Wurile (EW) against intracerebral hemorrhage (ICH) and explore its underlying mechanisms. ICH, a severe subtype of strok...