Modified Guilu Erxian Glue regulates Treg immune function to suppress bone marrow failure in aplastic anemia mice [0.03%]
改冰二仙胶通过调控Tregs免疫功能抑制再生障碍性贫血小鼠骨髓失效
Wei Liu,Pingxin Zhang,Jingmin Niu et al.
Wei Liu et al.
Background: Aplastic anemia (AA) is an autoimmune disorder characterized by impaired immunosuppressive function and abnormal differentiation of regulatory T (Treg) cells. Immunosuppressive treatment (IST) is a primary tre...
Tilianin: pharmacological potential, mechanisms of action, and future perspectives in traditional and modern medicine [0.03%]
tilianin：药理潜力、作用机制及在传统和现代医学中的未来展望
Mohammed A Abdel-Rasol,Ruwaidah A R Abbas,Wael M El-Sayed
Mohammed A Abdel-Rasol
Purpose: This review evaluates the therapeutic potential of tilianin, a flavonoid glycoside from medicinal plants, in managing chronic diseases such as cancer, cardiovascular diseases, neurodegenerative disorders, and met...
Reinforcement learning for LLM-based explainable TCM prescription recommendation with implicit preferences from small language models [0.03%]
基于小语言模型隐式偏好的LLM解释性中医处方推荐的强化学习
Xinyu Wang,Xiaohe Sun,Lei Yang et al.
Xinyu Wang et al.
Objective: In an effort to reinforce both the interpretability and accuracy of prescription recommendations in Traditional Chinese Medicine (TCM), this study puts forward a two-stage training framework that integrates kno...
Acupuncture accelerates wound healing via CGRP-RAMP1-TSP1-mediated macrophage M2 polarization [0.03%]
针灸通过CGRP-RAMP1-TSP1介导的M2型巨噬细胞极化促进伤口愈合
Xiaoer Liu,Junsheng Chen,Lingyue Zou et al.
Xiaoer Liu et al.
Background: Macrophages orchestrate the immune microenvironment during skin wound healing. While acupuncture's efficacy in accelerating wound healing is established, its underlying mechanisms, particularly those related t...
TCM-DS: a large language model for intelligent traditional Chinese medicine edible herbal formulas recommendations [0.03%]
TCM-DS：一种用于智能推荐中医食疗方的大规模语言模型
Xuanfeng Li,Haining He,Guibin Lu et al.
Xuanfeng Li et al.
Background: The concept of medicine and food homology in traditional Chinese medicine (TCM) emphasized the dual role of certain material as both food and medicine, offering nutritional and therapeutic benefits. Edible her...
Berberine ameliorates high-fat diet-induced metabolic disorders through promoting gut Akkermansia and modulating bile acid metabolism [0.03%]
番泻叶苷通过促进肠道Akk菌和调节胆汁酸代谢来改善高脂饮食诱导的代谢紊乱
Wei-Jian Hang,Rui Yin,Xi-Wei Kang et al.
Wei-Jian Hang et al.
Background: Coptidis Rhizoma, the rhizome of Coptis chinensis Franch., has long been employed in the treatment of diabetes. Its active component, berberine, has been utilized in clinical practice; however, the underlying ...
Cyclovirobuxine D ameliorates cardiomyocyte senescence in diabetic cardiomyopathy mice by enhancing mitochondrial function via sirtuin 3-ATP5O signal axis [0.03%]
环瑞宁丁D通过SIRT3-ATP5O信号轴增强线粒体功能改善糖尿病心肌病小鼠心肌细胞衰老
Jiang-Fei An,Hang Su,Xue-Ting Wang et al.
Jiang-Fei An et al.
Background: Diabetic cardiomyopathy (DCM) is a cardiovascular complication, with cardiomyocyte senescence being a key pathological process. Cyclovirobuxine D (CVB-D), the active compound in Buxus sinica (Rehd. et Wils.) v...
Electroacupuncture alleviates cognitive impairments in APP/PS1 mice via gastric vagal afferent-mediated activation of the nucleus tractus solitarius‒locus coeruleus noradrenergic circuit [0.03%]
电针可通过迷走传入‒NTS-蓝斑去甲肾上腺素神经环路改善APP/PS1小鼠认知障碍
Chaochao Yu,Man Li,Feng Shen et al.
Chaochao Yu et al.
Objective: Neuroinflammatory cascades mediated by the locus coeruleus-norepinephrine (LC-NE) system emerge as critical pathophysiological determinants governing the etiology and advancement of neurodegenerative disorders,...
Corynoline enhances sorafenib sensitivity in hepatocellular carcinoma via NOS3-mediated ROS production [0.03%]
小分子化合物Corynoline通过介导NOS3产生ROS增强肝癌细胞对Sorafenib的敏感性
Qiaoli Yi,Xi Chen,Shangjun Zhou et al.
Qiaoli Yi et al.
Background: The clinical application of sorafenib (Sora) in advanced hepatocellular carcinoma (HCC) is greatly limited due to its moderate efficacy and acquired resistance. Combination therapy with other agents holds prom...
Regulatory effects of Sini-San on bile acid homeostasis in the enterohepatic circulation of mice with liver fibrosis [0.03%]
四逆散对肝纤维化小鼠肠肝循环胆汁酸稳态的调控作用研究
Fangsi Zhu,Yijie Ding,Luyun Chen et al.
Fangsi Zhu et al.
Background: Sini-San (SNS), a classical traditional Chinese medicinal formula, has demonstrated promising potential in mitigating the progression of liver fibrosis (LF). Increasing evidence highlights that disruption of b...