Wendan decoction modulates Parasutterella to influence fatty acid metabolism in MAFLD via the FXR/PPARα/CYP4A12A axis [0.03%]
温胆汤通过FXR/PPARα/CYP4A12A轴调节Parasutterella影响非酒精性脂肪性肝病脂代谢的作用机制研究
Yiheng Zhang,Jiahao Wang,Weihao Zhu et al.
Yiheng Zhang et al.
Background: The host microbiota and hepatic drug-metabolizing enzymes are important mediators of the metabolism and biological effects of herbal components. Through bidirectional interactions, herbal medicines can also re...
Single-cell transcriptomics reveals how Shenfu Qiangxin pill ameliorates HFpEF by modulating cardiac cellular heterogeneity [0.03%]
单细胞转录组揭示参附强心汤通过调节心脏异质性改善射血分数保留的心力衰竭的作用机制
Yakun Yang,Haohao Gao,Zhifei Fu et al.
Yakun Yang et al.
Background: Heart failure with preserved ejection fraction (HFpEF) has currently emerged as a predominant and challenging subtype of heart failure, with high morbidity and mortality. However, the efficacy of current thera...
Pharmacological manipulation of Sema4D by salvianolic acid A mitigates diabetic retinopathy via inhibiting PlexinB1/RhoA/ROCK/pMLC2 signaling cascade involved in endothelial dysfunction [0.03%]
通过药理学操纵Sema4D来缓解糖尿病视网膜病变： salvianolic酸A通过抑制内皮功能障碍中参与的PlexinB1/RhoA/ROCK/pMLC2信号级联反应发挥作用
Weiwei Zheng,Ling Ning,Peiliang Shen et al.
Weiwei Zheng et al.
Background: Diabetic retinopathy (DR) is a leading cause of blindness. While anti-vascular endothelial growth factor (VEGF) therapy is effective, its utility is limited by variable patient response and the need for freque...
Co-production of high-purity floridoside and isofloridoside ameliorates MASH via Parabacteroides goldsteinii-UDCA-FXR enterohepatic axis [0.03%]
高纯度floridoside和isofloridoside的共生产通过Parabacteroides goldsteinii-UDCA-FXR肠肝轴改善MASH
Shuang Li,Rong Guo,Linxiao Sun et al.
Shuang Li et al.
Background: Metabolic dysfunction-associated steatohepatitis (MASH), the progressive form of metabolic dysfunction-associated fatty liver disease (MAFLD), is tightly linked to gut microbiota dysbiosis and disrupted bile a...
Beyond chemical composition: solvent pretreatment modulates supramolecular assembly and interactions with MRSA to enhance antibacterial efficacy of Scutellariae Radix-Coptidis Rhizoma [0.03%]
超越化学组成：溶剂预处理调节黄连-黄芩的超分子组装及与金黄色葡萄球菌的作用以增强抗菌功效
Yiqing Huang,Yihang Zhao,Jichang Wei et al.
Yiqing Huang et al.
Background: Scutellariae Radix-Coptidis Rhizoma herb pair is a classic traditional Chinese medicine (TCM) combination with heat-clearing, dampness-drying and detoxifying effects, extensively applied clinically against bac...
Modeling symptom-acupoint interactions via a heterogeneous graph learning framework for intelligent acupoint recommendation [0.03%]
基于异构图学习框架的智能化腧穴推荐症状与腧穴交互建模
Wei Lin,Jiaqi Chen,Zhuo Chen et al.
Wei Lin et al.
Objective: Acupuncture prescriptions involve complex compatibility mechanisms grounded in multi-symptom and multi-acupoint interactions, embodying millennia of clinical experience. Despite growing interest in computationa...
Guiqi Baizhu prescription attenuates 5-FU-induced intestinal mucositis by targeting IKKβ to inhibit M1 macrophage polarization [0.03%]
归芪百枝方通过靶向IKKβ抑制M1型巨噬细胞极化治疗5-氟尿嘧啶小鼠肠黏膜炎症损伤研究
Yu-Cen Zhou,Ya-Ling Li,Jing Ma et al.
Yu-Cen Zhou et al.
Background: Chemotherapy-induced intestinal mucositis (CIM), particularly that induced by agents such as 5-fluorouracil (5-FU), frequently leads to chemotherapy discontinuation. However, effective treatment options remain...
Atractylodis Macrocephalae Rhizoma ameliorates diarrhea induced by cold drinks and a high-fat diet by remodeling gut microecology and restoring barrier function [0.03%]
苍术改善冷饮和高脂饮食引起的腹泻：通过重塑肠道菌群和恢复屏障功能实现
Yajuan Tian,Chenxing Wang,Yuzhong Du et al.
Yajuan Tian et al.
Background: Atractylodis Macrocephalae Rhizoma (AMR) has traditionally been utilized for treating spleen deficiency diarrhea. Nevertheless, the effects and mechanisms of AMR on diarrhea caused by the consumption of cold d...
Lycorine ameliorates diabetic nephropathy by targeting RAGE and inhibiting the HMGB1/RAGE/NF-κB signaling axis [0.03%]
石蒜碱通过靶向RAGE和抑制HMGB1/RAGE/NF-κB信号轴改善糖尿病肾病
Zheng Xu,Xuejin Jin,Miao Yuan et al.
Zheng Xu et al.
Background: Diabetic nephropathy (DN) is a major microvascular complication of diabetes and a leading cause of end-stage renal disease. Chronic inflammation plays a pivotal role in the pathogenesis of DN. Lycorine (LY), a...
Esophageal epithelial cell-derived kynurenine drives Th17 inflammation in reflux esophagitis and is targeted by Xuanfu Daizhe decoction [0.03%]
旋复代赭汤通过作用于食管鳞状上皮细胞治疗反流性食管炎中的Th17型炎症反应机制研究——以色氨酸代谢为切入点的研究
Jing Xun,Qi Gao,Huichao Yang et al.
Jing Xun et al.
Background: The role of immunometabolic dysregulation in reflux esophagitis (RE), particularly the metabolic drivers of pathogenic T helper 17 (Th17) cell differentiation, is not fully understood. Although Xuanfu Daizhe D...