Lactylation: a metabolic-epigenetic bridge in diabetic kidney disease and a therapeutic target for TCM [0.03%]
乳酰化：糖尿病肾脏疾病的代谢表观遗传学桥梁及中药治疗靶点
Wen Zhang,Xiangdong Zhu,Yan Zhang et al.
Wen Zhang et al.
Lactate-derived lactylation, as an emerging epigenetic mechanism driven by lactic acid metabolism, plays a pivotal bridging role in diabetic kidney disease (DKD), linking metabolic dysregulation to pathological gene expression. Research ind...
Optimized New Shengmai Powder suppresses ferroptosis in ischemic cardiomyocytes via cGMP-PKG signalling [0.03%]
优化的新生脉粉通过cGMP-PKG信号通路抑制缺血性心肌细胞铁死亡
Zeyu Zhang,Zhihua Yang,Zhuangzhuang Jia et al.
Zeyu Zhang et al.
Background: Shengmai Powder is a classic Traditional Chinese Medicine formula that has been used for centuries to manage cardiovascular diseases characterized by "Qi-Yin deficiency with blood stasis." Optimized New Shengm...
Yixinshu attenuates myocardial infarction via SHP1/JAK2/STAT3-mediated regulation of mitochondrial function and apoptosis [0.03%]
益心舒通过SHP1/JAK2/STAT3介导的线粒体功能和凋亡调节缓解心肌梗死
Xueting Wang,Xinrui Wang,Yang Liu et al.
Xueting Wang et al.
Yixinshu (YXS), a traditional Chinese formula, is applied for coronary artery diseases in clinic, however, its cardioprotective mechanisms remain unclear. At present, the role and underlying mechanisms of YXS is to elucidate in enhancing po...
44-year journey (1980-2024): scientometric insights into Sigesbeckiae herba and update on its medicinal properties and phytochemicals profile [0.03%]
44年历程（1980-2024）：米斛药理和化学研究的文献计量学见解及其医学特性与植物化学成分更新
Parsa Dar,Cui Wenqing,Shaden A M Khalifa et al.
Parsa Dar et al.
This study uses Scientometric analysis to review Sigesbeckiae Herba (SH) research worldwide from 1980 to 2024. Data-driven analysis identifies patterns, partnerships, and possibilities. Due to its wide profile and traditional medical uses, ...
Weiyan Tongluo Granules attenuate gastric intestinal metaplasia through PPARγ/NF-κB/CDX2 signaling pathway [0.03%]
胃舒颗粒通过PPARγ/NF-κB/CDX2信号通路干预胃黏膜肠上皮化生
Yimin Liang,Shijie Su,Ting Jin et al.
Yimin Liang et al.
Background: Gastric intestinal metaplasia (GIM) is a precancerous condition characterized by the replacement of gastric mucosa with intestinal-like epithelium, posing a considerable risk for gastric cancer with no effecti...
A top-down neural circuit for affective-motivational responses of pain relief induced by electroacupuncture [0.03%]
电针镇痛诱发情感动机反应的自上而下神经环路
Hui Liu,Xin Jia,Zouqin Huang et al.
Hui Liu et al.
Background: Peripheral neuromodulation, which can be considered as a flow of signals from the body to the brain, influences mental and psychological states. However, whether peripheral neuromodulation, particularly electr...
A novel Chinese medicine formula against hyperuricemia-induced kidney inflammation involving pyroptosis inhibition via modulating AMPK-TLR4-NLRP3 pathway [0.03%]
一种新型中药复方通过调控AMPK-TLR4-NLRP3信号通路抑制pyroptosis治疗高尿酸肾炎的作用及机制研究
Yuan-Yang Tian,Yu-Lin Wu,Koon Kit Lam et al.
Yuan-Yang Tian et al.
Background: Hyperuricemia (HUA), characterized by elevated serum uric acid (SUA) level, serves as a precursor of gout. Gout formula (GF), an empirical formula, has been prescribed in Chinese medicine practice for many yea...
Traditional Chinese Medicine for osteoporosis management: from molecular mechanisms to drug discovery [0.03%]
中医药在骨质疏松症防治中的应用：从分子机制到药物发现
Shenyu Yan,Qiaohui Du,Lijun Zhao et al.
Shenyu Yan et al.
Osteoporosis, a prevalent skeletal disorder, poses significant challenges in aging populations. Traditional Chinese Medicine (TCM) offers a multi-target approach to addressing its complex pathogenesis, which involves hormonal imbalance, oxi...
Tuning and clinical application of large language models in Traditional Chinese Medicine: scoping review [0.03%]
中医领域的大规模语言模型的调优与临床应用：综述研究
Changxiao Han,Guangyi Yang,Hongtao Li et al.
Changxiao Han et al.
Background and objective: Large Language Models (LLMs) show significant potential in healthcare, but their application in Traditional Chinese Medicine (TCM) lacks systematic evaluation. This study aims to comprehensively ...
Polymeric micelle hydrogel of Resina Draconis enables mechanistically targeted protection against skin photoaging [0.03%]
龙血树脂聚meric micelle水凝胶通过作用机制保护皮肤抗光老化
Mengzhu Liu,Yuqing Huang,Wanyang Sun et al.
Mengzhu Liu et al.
Resina Draconis (RD), a traditional Chinese medicinal resin renowned for its potent antioxidant, anti-inflammatory, and tissue-repairing properties, holds promise for combating skin photoaging. However, its therapeutic translation has been ...