Pharmacokinetics and homeostatic impact of golden bile powder: evidence from surrogate analyte-based UPLC-MS/MS in rats [0.03%]
基于替代标志物的UPLC-MS/MS研究金胆粉在大鼠体内的药动学及稳态效应
Xin Yu,Siyang Wu,Huinan Wang et al.
Xin Yu et al.
Background: Golden bile powder (GBP), an artificial bear bile powder, is used for liver protection and contains taurine-conjugated bile acids (BAs) with broad pharmacological activities. However, its pharmacokinetics and ...
Sichuan pepper, Zanthoxylum bungeanum Maxim., suppresses human coronavirus OC43 infection by inhibiting viral entry and impairing autolysosome accumulation [0.03%]
山椒种子抑制人类冠状病毒OC43的感染及其作用机制研究
Hyeonjeong Park,In Jin Ha,Young-Hee Jin et al.
Hyeonjeong Park et al.
Background: The dried pericarp of Zanthoxylum bungeanum Maxim. (Rutaceae), widely recognized as Sichuan pepper (Hua Jiao), is a prominent herb within the Traditional Chinese Medicine (TCM), boasting a long and well-docume...
TCMNet: an AI-driven strategy for optimizing traditional Chinese medicine [0.03%]
基于人工智能优化中医药的策略——中医藏药网络(TCMNet)
Shuoyan Tan,Xin Shao,Xuting Zhang et al.
Shuoyan Tan et al.
Background: Artificial intelligence (AI), particularly large language models (LLMs), have provided powerful tools for systematically modeling the complexity of traditional Chinese medicine (TCM). To overcome the limitatio...
Tadehagi triquetrum aqueous extract ameliorates diabetic kidney disease through mitigating epithelial senescence via the PTEN/AKT/mTOR signaling pathway [0.03%]
三萼风花提取物通过PTEN/AKT/mTOR信号通路改善糖尿病肾病中上皮细胞衰老的作用研究
Li Li,Liying Xue,Chu Xue et al.
Li Li et al.
Background: Tadehagi triquetrum, a well-known medicinal plant widely consumed in Asia, possesses hypoglycemic properties. However, its precise impact in managing diabetic complications remains insufficiently understood. T...
Matrine improves bile acid metabolism and reduces inflammatory and oxidative stress in colitis via the JAK2 pathway [0.03%]
小檗胺通过JAK2信号途径改善结肠炎肝内胆汁酸代谢、降低炎症及氧化应激水平
Zhi-Xian Jiang,Xue-Liang Chen,Qi Sun et al.
Zhi-Xian Jiang et al.
Background: Dysbiosis during colitis alters the conversion of primary to secondary bile acids by gut microbiota, which affects bile acid receptor signaling and may exacerbate mucosal inflammation in experimental colitis m...
Multi-omics analysis reveals gut microbiota remodeling and lipid metabolism regulation during the treatment of nonalcoholic fatty liver disease with Yindan Pinggan capsule [0.03%]
多组学分析揭示茵丹平肝胶囊治疗非酒精性脂肪性肝病中的肠道菌群重塑及脂质代谢调节作用
Jinli Hou,Sen Li,Fengrong Zhang et al.
Jinli Hou et al.
Background: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disorder with limited treatment options. Yindan Pinggan capsule (YDPG), a traditional Chinese medicine, has demonstrated potential in managing...
Gut microbiota-metabolism-immunity axis: a novel perspective of traditional Chinese medicine in hepatocellular carcinoma treatment [0.03%]
肠道微生态-代谢-免疫轴：中医药治疗肝癌的新视角
Xuemei Zhang,Liming Zheng,Jia Shi et al.
Xuemei Zhang et al.
Hepatocellular carcinoma (HCC) is a highly aggressive malignancy characterized by complex metabolic dysregulation and immune evasion mechanisms, leading to poor prognosis and limited treatment efficacy. Growing evidence underscores the crit...
Targeting oncogenic NTSR1 with liensinine reprograms Gq-mediated signaling to suppress lung adenocarcinoma [0.03%]
黄酮类药物liensinine靶向致癌基因NTSR1重编程Gq介导信号通路以抑制肺腺癌发生发展
Yongfu Wang,Wei Liu,Pengzhuo Tao et al.
Yongfu Wang et al.
Background: Lung adenocarcinoma (LUAD) is a leading cause of cancer death. Neurotensin receptor 1 (NTSR1), a G protein-coupled receptor, is overexpressed in LUAD and linked to poor prognosis, but its therapeutic potential...
OptiSyn: an interpretable, multi-omics-driven graph convolutional network framework for synergy-oriented drug combination design in disease treatment [0.03%]
基于多组学的药物组合设计图卷积网络框架用于疾病治疗中的协同作用分析
Yinli Shi,Jun Liu,Guoduan Zeng et al.
Yinli Shi et al.
Background: Bioinformatics and large-scale computational modelling have emerged as essential research fields in modern biomedical science, enabling drug discovery and therapeutic optimisation. A unique and potent technica...
Unraveling the mechanism of tripterygium glycosides tablets-induced liver injury and the protective role of total glucosides of peony from immune-metabolic dysregulation to multi-cellular cascade [0.03%]
从免疫代谢失调到多细胞级联广防己甲素通过调控TLR4/NF-κB信号通路抑制氟硅酸致肝细胞损伤的作用机制研究
Yi Zhang,Zihe Ding,Xiaoyue Wang et al.
Yi Zhang et al.
Tripterygium glycosides tablets (TGT) are effective against autoimmune diseases but cause significant drug-induced liver injury (DILI) that limits clinical use. While TGT disrupts hepatic iron-lipid homeostasis and co-administration with To...