Two methoxy derivatives of resveratrol, 3,3',4,5'-tetramethoxy-trans-stilbene and 3,4',5-trimethoxy-trans-stilbene, suppress lipopolysaccharide-induced inflammation through inactivation of MAPK and NF-κB pathways in RAW 264.7 cells [0.03%]
茋类茋的两种甲醚衍生物通过抑制MAPK和NF-κB信号通路来抑制脂多糖诱导的炎症反应
Chunxiu Zhou,Xutao Zhang,Cheng-Chao Ruan et al.
Chunxiu Zhou et al.
Background: 3,3',4,5'-tetramethoxy-trans-stilbene (3,3',4,5'-TMS) and 3,4',5-trimethoxy-trans-stilbene (3,4',5-TMS) are two methoxy derivatives of resveratrol. Previous researches have proved that resveratrol and its anal...
Traditional Chinese Medicine in nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives [0.03%]
中医药治疗非酒精性脂肪肝病：分子见解和治疗前景
Xianmin Dai,Jiayi Feng,Yi Chen et al.
Xianmin Dai et al.
Nonalcoholic fatty liver disease (NAFLD) has become the world's largest chronic liver disease, while there is still no specific drug to treat NAFLD. Traditional Chinese Medicine (TCM) have been widely used in hepatic diseases for centuries ...
Pterostilbene alleviates pulmonary fibrosis by regulating ASIC2 [0.03%]
Pterostilbene通过调节ASIC2缓解肺纤维化
Yanfang Peng,Yingwen Zhang,Yabing Zhang et al.
Yanfang Peng et al.
Background: Idiopathic pulmonary fibrosis (IPF) is a serious chronic disease of the respiratory system, but its current treatment has certain shortcomings and adverse effects. In this study, we evaluate the antifibrotic a...
Natural products provide a new perspective for anti-complement treatment of severe COVID-19: a review [0.03%]
天然产物为重症COVID-19的补体治疗提供新思路：综述
Yadong Fan,Ying Wang,Shuang Yu et al.
Yadong Fan et al.
Exaggerated immune response and cytokine storm are accounted for the severity of COVID-19, including organ dysfunction, especially progressive respiratory failure and generalized coagulopathy. Uncontrolled activation of complement contribut...
Shenzhi Jiannao formula ameliorates vascular dementia in vivo and in vitro by inhibition glutamate neurotoxicity via promoting clathrin-mediated endocytosis [0.03%]
神智健脑方通过促进网格蛋白依赖的内吞作用抑制谷氨酸神经毒性改善血管性痴呆体内外研究
Danfeng Tian,Yangyang Guo,Dandan Zhang et al.
Danfeng Tian et al.
Background: Synaptic damage and glutamate excitotoxicity have been implicated in the pathogenesis of vascular dementia (VD). Clathrin, RAB5B and N-methyl-D-aspartic acid receptor 1 (NMDAR1) proteins play a vital role in e...
Assessment of the reporting quality of randomised controlled trials of massage [0.03%]
按摩随机对照试验的报告质量评估
Xuan Zhang,Lin Zhang,Weifeng Xiong et al.
Xuan Zhang et al.
Objective: To assess the reporting quality of randomised controlled trials (RCTs) of massage, particularly whether necessary elements related to massage interventions were adequately reported. ...
Current status of traditional Chinese medicine for the treatment of COVID-19 in China [0.03%]
中医药治疗新冠肺炎现状分析——基于中国的经验
Liang Chu,Fang Huang,Mengdan Zhang et al.
Liang Chu et al.
An ongoing outbreak of severe respiratory illness and pneumonia caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2) commenced in December 2019, and the disease was named as coronavirus disease 2019 (COVID-19). Soon after, scie...
The toxicology and detoxification of Aconitum: traditional and modern views [0.03%]
附子的毒理与解毒：传统和现代观点
Yau-Tuen Chan,Ning Wang,Yibin Feng
Yau-Tuen Chan
Aconitum carmichaeli Debx.-derived herbal medicine has been used for anti-inflammation and anti-arrhythmia purpose for more than two thousand years. It is processed into Chuanwu (Radix Aconiti praeparata) and Fuzi (Radix Aconiti lateralis p...
Herbal therapy for ameliorating nonalcoholic fatty liver disease via rebuilding the intestinal microecology [0.03%]
重建肠道菌群治疗改善非酒精性脂肪肝的中药疗法
Xiao-Fang Yang,Ming Lu,Lijiao You et al.
Xiao-Fang Yang et al.
The worldwide prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing, and this metabolic disorder has been recognized as a severe threat to human health. A variety of chemical drugs have been approved for treating NAFLD, howev...
Insights into the molecular mechanisms of Huangqi decoction on liver fibrosis via computational systems pharmacology approaches [0.03%]
基于计算系统药理学方法探讨黄芪汤抗肝纤维化的分子机制
Biting Wang,Zengrui Wu,Weihua Li et al.
Biting Wang et al.
Background: The traditional Chinese medicine Huangqi decoction (HQD) consists of Radix Astragali and Radix Glycyrrhizae in a ratio of 6: 1, which has been used for the treatment of liver fibrosis. In this study, we tried ...