Thlaspi arvense attenuates colitis-associated colorectal tumorigenesis through suppression of neutrophil recruitment via the NOD/NF-κB pathway [0.03%]
硫化翼茎芥通过NOD / NF-κB途径抑制中性粒细胞募集从而减轻结肠炎相关性结直肠肿瘤发生率
Ziwei Wang,Wenkai Wang,Chaowei Wang et al.
Ziwei Wang et al.
Background: In colitis-associated colorectal cancer (CAC), chronic inflammation is the primary driver of tumorigenesis. A critical event in this process is the massive recruitment of neutrophils, which, while part of the ...
The role of Traditional Chinese Medicine in the management of liver disease: targeting gut microbiome [0.03%]
中医药通过靶向肠道菌群治疗肝病的作用机制研究
Yifan Zhang,Hongkun Li,Fei Yu et al.
Yifan Zhang et al.
In recent years, liver disease have become a major contributor to global morbidity and mortality, with current clinical treatments often limited by late diagnosis and rapid progression. This review aims to explore the underexplored role of ...
Jieduquyuziyin prescription for systemic lupus erythematosus: a system-level therapeutic strategy for immunological recalibration [0.03%]
解毒祛瘀治则治疗系统性红斑狼疮：免疫校正的系统论治疗策略
Yihong Gan,Jingqun Liu,Shihui Zhou et al.
Yihong Gan et al.
Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease involving immune dysregulation, metabolic reprogramming, and multi-organ damage. The Jieduquyuziyin prescription (JP), a contemporary Chinese ...
Schisandrol B protects against lithocholic acid-induced cholestatic liver injury in mice through mitochondrial biogenesis [0.03%]
薛苈醇B通过线粒体生物发生缓解胆酸致小鼠肝损伤作用研究
Xiao Yang,Hangfei Liang,Xuan Li et al.
Xiao Yang et al.
Background: Mitochondrial biogenesis plays a vital role in various types of hepatocyte injury. Schisandrol B (SolB), a bioactive lignan isolated from Schisandra sphenanthera, exerts a significant hepatoprotective effect a...
Ganoderma lucidum mediates microglial polarization and ameliorates experimental autoimmune encephalomyelitis by reducing oxidative stress and inhibiting NF-κB/STAT3 pathway [0.03%]
灵芝通过减少氧化应激和抑制NF-κB / STAT3途径介导小胶质细胞极化并改善自身免疫性脑脊髓炎
Lu Zhang,Jie Chen,Sauchu Yuen et al.
Lu Zhang et al.
Multiple Sclerosis (MS) is a neuroinflammatory disease affecting the central nervous system (CNS), for which effective therapeutic strategies remain limited. Ganoderma Lucidum (GL) is a nature healthy food supplement whose effects on MS rem...
Moxibustion delays ovarian aging by regulating mitochondrial biogenesis and improving oocyte quality [0.03%]
温针灸通过调节线粒体生物生成和改善卵母细胞质量来推迟卵巢衰老
Yaoli Yin,Yan Xu,Zemin Li et al.
Yaoli Yin et al.
Background: The growing trend of delayed childbearing in contemporary society has made fertility preservation a significant issue, prompting the search for diverse therapeutic options. Conversely, moxibustion is gaining i...
Erianin facilitates pyroptosis in endometrial cancer via targeting m6A reader YTHDF1 [0.03%]
姜黄素通过靶向m6A阅读蛋白YTHDF1促进子宫内膜癌细胞的炎性焦亡现象
Wan Shu,Xing Zhou,Rong Zhao et al.
Wan Shu et al.
Background: Endometrial cancer (EC) is a gynecological malignancy that originates from the endometrial epithelium and has a poor prognosis when advanced, recurrent, or metastatic. The limited therapeutic efficacy and seve...
ZhiXiaoSanZheng formula ameliorates podocyte injury in diabetic kidney disease by inhibiting ferroptosis: integrated network pharmacology and experimental validation [0.03%]
基于网络药理学和实验验证的知小散证方通过抑制铁死亡改善糖尿病肾病足细胞损伤作用机制研究
Shaofeng Zhou,Huijuan Zheng,Xinghua Zhang et al.
Shaofeng Zhou et al.
Background: Diabetic kidney disease (DKD) is widely recognized as a major contributor to end-stage renal disease, in which podocyte injury serves as an important pathological basis for disease progression. ZhiXiaoSanZheng...
Si-Ni-San alleviates depression-like behavior via regulating the gut microbiota-tryptophan metabolism-AhR/NF-κB pathway axis [0.03%]
参附散通过调节肠道菌群-色氨酸代谢-AhR/NF-κB信号通路轴改善抑郁样行为
Qiang Xiao,Zhaoyi Wen,Huang Zhan et al.
Qiang Xiao et al.
Background: Si-Ni-San (SNS), a classic herbal formula from the Treatise on Cold Damage Diseases, is used to treat depression by relieving "liver qi stagnation". However, the underlying mechanism remains unclear. ...
Electroacupuncture inhibited neuronal apoptosis through PGAM5/FUNDC1-dependent mitophagy after ischemic stroke [0.03%]
电针通过PGAM5/FUNDC1依赖的线粒体自噬抑制脑缺血后的神经元凋亡
Li Zhou,Yicheng Peng,Mingchao Fu et al.
Li Zhou et al.
Neuronal apoptosis persists throughout ischemic stroke. This leads to massive neuron loss and severely impairs recovery of neurological function. Clinical evidence has confirmed that electroacupuncture (EA) effectively improves neurological...