Filiform fire needling therapy relieves T cells-mediated melanocyte apoptosis and dysfunction by inhibiting JAK/STAT3 pathway via Mfsd4a in vitiligo [0.03%]
细针火针疗法通过Mfsd4a抑制JAK/STAT3信号通路缓解白癜风中T细胞介导的黑素细胞凋亡和功能障碍
Yue Shi,Dong Chen,Yao Wang et al.
Yue Shi et al.
We investigated the molecular mechanism of filiform fire needling therapy (FFN), an effective treatment option for vitiligo, focusing on its role in relieving depigmentation. Firstly, we validated the efficacy and safety of FFN in a study w...
Jiahao Li,Zhennan Fei,Yingjiang Xie et al.
Jiahao Li et al.
The development of deep learning has brought unprecedented opportunities for automatic acupoint localization, surmounting many limitations of traditional methods and machine learning, and significantly propelling the modernization of Tradit...
Qu-zhuo-tong-bi decoction exerts gouty arthritis therapy by skewing macrophage polarization through butanoate metabolism [0.03%]
_QU芍同痹_汤通过丁酸代谢改变巨噬细胞极化治疗痛风性关节炎
Siyue Song,Xianghui Wen,Fusen Chen et al.
Siyue Song et al.
Background: Qu-zhuo-tong-bi decoction (QZTBD), a traditional Chinese medicine (TCM), has demonstrated efficacy in the treatment of gouty arthritis. However, to date, the precise pharmacological mechanisms remain unclear. ...
Integrating multi-omics and machine learning strategies to explore the "gene-protein-metabolite" network in ischemic heart failure with Qi deficiency and blood stasis syndrome [0.03%]
整合多组学和机器学习策略探索缺血性心力衰竭气虚血瘀证“基因-蛋白-代谢物”网络
Jingjing Wei,Aolong Wang,Peng Yu et al.
Jingjing Wei et al.
Background: Ischemic heart failure (IHF) is a multifaceted syndrome associated with significant mortality and high hospitalization rates globally. According to traditional Chinese medicine (TCM) theory, Qi Deficiency and ...
The emerging role of mitochondria in the pharmacological and toxicological effects of Tripterygium wilfordii Hook F: functions, targets and new therapeutic applications [0.03%]
狼毒钩藤素的药理和毒性作用中线粒体的作用：功能、靶点及新的治疗应用
Zhonghao Liu,Dan Li,Xiongwen Yang et al.
Zhonghao Liu et al.
Tripterygium wilfordii Hook F (TWHF) is a traditional Chinese medicine with multifaceted pharmacological properties, has faced clinical application challenges due to its dose-limiting organ toxicity. Through a systematic analysis of current...
Aster tataricus extract and its active compounds display a broad spectrum of antiviral activity in vitro and in vivo [0.03%]
毛蕊花属塔特拉种提取物及其活性化合物体内外抗病毒谱广
Nuwan Gamage,Ji-Won Cha,Ji-Soo Jeong et al.
Nuwan Gamage et al.
Background: Aster tataricus, a perennial terrestrial herb with a rich history of use in traditional medicine, is renowned for its therapeutic properties. However, despite the widespread use of Aster tataricus, its antivir...
Ganoderma lucidum spore oil alleviates psychological stress-evoked tumor progression by enhancing FcγR-mediated macrophage phagocytosis [0.03%]
灵芝孢子油通过增强Fcγ受体介导的巨噬细胞吞噬作用来缓解心理压力引起的肿瘤进展
Dong-Dong Li,Zi-Xuan Li,Yang-Fan Zhou et al.
Dong-Dong Li et al.
Background: Ganoderma lucidum (G. lucidum), has been documented as a medicinal herb in classical texts and officially recognized in both Eastern and Western pharmacopeias. G. lucidum spore oil (GLSO), a lipid substance ex...
Acupuncture promotes muscle cells ATP metabolism in ST36 acupoint local exerting effect by activating TRPV1/CaMKII/AMPK/PGC1α signaling pathway [0.03%]
针刺足三里穴位促进局部肌细胞ATP代谢的作用及其机制研究：瞬时受体电位香草酸亚型1/钙调素依赖性蛋白激酶Ⅱ/腺苷酸活化蛋白激酶/过氧化物酶体增殖激活受体γ共表达转录因子α信号通路的介导作用
Zhihan Chen,Kaifang Yao,Xinrui Wang et al.
Zhihan Chen et al.
At present, a number of studies have shown that acupuncture at Zusanli (ST 36) can relieve pain, but the changes of local microenvironment in the acupoint area after acupuncture have not been elucidated. As a temperature and pain receptor, ...
Effects of solamargine in hepatic metastasis of colorectal cancer: induction of ferroptosis and elimination of cancer stem cells [0.03%]
索马arginine对结直肠癌肝转移效果的研究：促铁死亡和耗竭癌症干细胞的作用
Shenglan Liu,Junhong Wu,Hao Huang et al.
Shenglan Liu et al.
Background: Colorectal cancer (CRC) is a prevalent malignant tumor globally, ranking third in incidence and second in mortality. Metastasis is the main cause of death in patients with CRC. Solanum nigrum L. (SNL), a tradi...
Juanbi Qianggu Formula inhibits fibroblast-like synovicytes activation via repressing LncRNA ITSN1-2 to promote RIP2 K48 ubiquitination [0.03%]
关节滑膜增生抑制方通过调控长链非编码RNA ITSN1-2促进RIP2的K48连接泛素化降解抑制类风湿性关节炎滑膜成纤维细胞活化
Yanqin Bian,Fang Li,Xinyu A et al.
Yanqin Bian et al.
Background: Long non-coding RNA ITSN1-2(lncRNA ITSN1-2) promotes fibroblast-like synovicytes (FLS) proliferation and suppress apoptosis through activation of the NOD2/RIP2 signaling pathway, thereby exacerbating synovitis...