Lola regulates Drosophila olfactory projection neuron identity and targeting specificity [0.03%]
Lola调控果蝇嗅觉投射神经元的身份和靶向特异性
Maria Lynn Spletter,Jian Liu,Justin Liu et al.
Maria Lynn Spletter et al.
Background: Precise connections of neural circuits can be specified by genetic programming. In the Drosophila olfactory system, projection neurons (PNs) send dendrites to single glomeruli in the antenna lobe (AL) based up...
Lateral motor column axons execute a ternary trajectory choice between limb and body tissues [0.03%]
侧向运动柱轴突在四肢和身体组织之间执行三元轨迹选择
Victor Luria,Ed Laufer
Victor Luria
Background: Neuronal topographic map formation requires appropriate selection of axonal trajectories at intermediate choice points prior to target innervation. Axons of neurons in the spinal cord lateral motor column (LMC...
A specific box switches the cell fate determining activity of XOTX2 and XOTX5b in the Xenopus retina [0.03%]
非洲爪蟾视网膜中XOTX2和XOTX5b决定细胞命运的特异性转换
Marco Onorati,Federico Cremisi,Yang Liu et al.
Marco Onorati et al.
Background: Otx genes, orthologues of the Drosophila orthodenticle gene (otd), play crucial roles in vertebrate brain development. In the Xenopus eye, Xotx2 and Xotx5b promote bipolar and photoreceptor cell fates, respect...
Zac1 functions through TGFbetaII to negatively regulate cell number in the developing retina [0.03%]
Zac1通过TGFβII抑制视网膜发育中的细胞数量增加的功能研究
Lin Ma,Robert Cantrup,Annie Varrault et al.
Lin Ma et al.
Background: Organs are programmed to acquire a particular size during development, but the regulatory mechanisms that dictate when dividing progenitor cells should permanently exit the cell cycle and stop producing additi...
Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterning [0.03%]
Sp8与Fgf8呈互惠诱导关系但在前后皮质区模式形成中作用相反
Setsuko Sahara,Yasuhiko Kawakami,Juan Carlos Izpisua Belmonte et al.
Setsuko Sahara et al.
Telencephalic patterning centers, defined by the discrete expression domains of distinct morphogens, Fgfs in the commissural plate (CoP), Wnts and Bmps in the cortical hem, and a ventral domain of Sonic hedgehog (Shh), are postulated to est...
Natalia Sánchez-Soriano,Guy Tear,Paul Whitington et al.
Natalia Sánchez-Soriano et al.
One of the most fascinating processes during nervous system development is the establishment of stereotypic neuronal networks. An essential step in this process is the outgrowth and precise navigation (pathfinding) of axons and dendrites to...
Genetic interplay between the transcription factors Sp8 and Emx2 in the patterning of the forebrain [0.03%]
转录因子Sp8和Emx2在前脑模式建立过程中的相互作用研究
Andreas Zembrzycki,Gundula Griesel,Anastasia Stoykova et al.
Andreas Zembrzycki et al.
Background: The forebrain consists of multiple structures necessary to achieve elaborate functions. Proper patterning is, therefore, a prerequisite for the generation of optimal functional areas. Only a few factors have b...
Melissa M Rolls,Daisuke Satoh,Peter J Clyne et al.
Melissa M Rolls et al.
Background: Proper neuronal function depends on forming three primary subcellular compartments: axons, dendrites, and soma. Each compartment has a specialized function (the axon to send information, dendrites to receive i...
Electroporation-based methods for in vivo, whole mount and primary culture analysis of zebrafish brain development [0.03%]
电穿孔法在整体和原代培养中分析斑马鱼脑发育中的应用
Michael Hendricks,Suresh Jesuthasan
Michael Hendricks
Background: Electroporation is a technique for the introduction of nucleic acids and other macromolecules into cells. In chick embryos it has been a particularly powerful technique for the spatial and temporal control of ...
Antagonism between Notch and bone morphogenetic protein receptor signaling regulates neurogenesis in the cerebellar rhombic lip [0.03%]
notch和骨形态生成蛋白受体信号通路的拮抗作用调节小脑菱形神经节细胞的发生发育
Robert P Machold,Deborah Jones Kittell,Gordon J Fishell
Robert P Machold
Background: During the embryonic development of the cerebellum, neurons are produced from progenitor cells located along a ventricular zone within dorsal rhombomere 1 that extends caudally to the roof plate of the fourth ...