Long noncoding RNA LINC00520 accelerates lung adenocarcinoma progression via miR-1252-5p/FOXR2 pathway [0.03%]
长非编码RNA LINC00520通过miR-1252-5p/FOXR2途径促进肺腺癌进展
Xinyue Chen,Huimin Chen,Miaowen Liu et al.
Xinyue Chen et al.
It has been corroborated that long noncoding RNA (lncRNA) played fundamental function in various human malignancies development including lung adenocarcinoma (lung ADC). In our study, LINC00520 roles in lung ADC tumorigenesis were explored....
MiR-27b-3p inhibits the progression of renal fibrosis via suppressing STAT1 [0.03%]
MiR-27b-3p通过抑制STAT1抑制肾纤维化进展
Lin Bai,Yongtao Lin,Juan Xie et al.
Lin Bai et al.
Renal fibrosis is a pathologic change in chronic kidney disease (CKD). MicroRNAs (miRNAs) have been shown to play an important role in the development of renal fibrosis. However, the biological role of miR-27b-3p in renal fibrosis remains u...
High-resolution melting effectively pre-screens for TP53 mutations before direct sequencing in patients with diffuse glioma [0.03%]
高分辨率熔解可在直接测序前有效筛选弥漫性胶质瘤患者的TP53突变
Kiyotaka Saito,Kiyotaka Yokogami,Kazunari Maekawa et al.
Kiyotaka Saito et al.
TP53 mutations are important molecular markers in diffuse astrocytic tumors and medulloblastomas. We examined the efficacy of a pre-screening method for high-resolution melting (HRM) analysis of TP53 mutation before direct sequencing using ...
Uptake of fluorescent D- and L-glucose analogues, 2-NBDG and 2-NBDLG, into human osteosarcoma U2OS cells in a phloretin-inhibitable manner [0.03%]
葡萄糖类似物2-NBDG和2-NBDLG被鬼臼茋抑制的人类成骨肉瘤U2OS细胞摄取
Tetsuya Ogawa,Ayako Sasaki,Koki Ono et al.
Tetsuya Ogawa et al.
Mammalian cells take in D-glucose as an essential fuel as well as a carbon source. In contrast, L-glucose, the mirror image isomer of D-glucose, has been considered merely as a non-transportable/non-metabolizable control for D-glucose. We h...
Upregulation of miR-144-3p protects myocardial function from ischemia-reperfusion injury through inhibition of TMEM16A Ca2+-activated chloride channel [0.03%]
miR-144-3p上调通过抑制TMEM16ACa2+激活的Cl-通道保护心肌免受缺血再灌注损伤
Guoxun Yang,Xiao Tang,Ling Tan et al.
Guoxun Yang et al.
Myocardial ischemia/reperfusion injury (MIRI) is a major cause of acute cardiac injury that is associated with high morbidity and mortality, and for which specific treatments are lacking. In this study, we investigated the underlying molecu...
PI3K/AKT signaling pathway: a possible target for adjuvant therapy in COVID-19 [0.03%]
PI3K/AKT信号通路可能是COVID-19adjuvant治疗的作用靶点
Mohammad Rafi Khezri
Mohammad Rafi Khezri
StarD13 differentially regulates migration and invasion in prostate cancer cells [0.03%]
星蛋白D13不同水平地调节前列腺癌细胞的迁移和侵袭能力
Leila Jaafar,Isabelle Fakhoury,Sahar Saab et al.
Leila Jaafar et al.
Prostate cancer is the second most commonly diagnosed cancer in men and one of the main leading causes of cancer deaths among men worldwide. Rapid uncontrolled growth and the ability to metastasize to other sites are key hallmarks in cancer...
CBX8 acts as an independent RNA-binding protein to regulate the maturation of miR-378a-3p in colon cancer cells [0.03%]
结肠癌细胞中CBX8作为独立的RNA结合蛋白调控miR-378a-3p成熟的作用
Xin Song,Wu Ning,Jinwei Niu et al.
Xin Song et al.
CBX8 is the core component of the PCG family protein PRC1 complex. It is overexpressed in many solid tumors and plays an important role in the prognosis and biological behaviors of tumors such as occurrence, development, invasion, and metas...
SH2 domain-containing protein tyrosine phosphatase-2 (SHP-2) prevents cardiac remodeling after myocardial infarction through ERK/SMAD signaling pathway [0.03%]
含有SH2结构域的酪氨酸磷酸酶-2通过ERK/SMAD信号通路预防心肌梗死后的心室重构
Yong-Gang Lu,He Tan,Qian Ma et al.
Yong-Gang Lu et al.
In this study, we aimed to investigate the role of SH2 domain-containing protein tyrosine phosphatase-2 (SHP-2) in cardiac remodeling after myocardial infarction (MI) and explore the underlying molecular mechanism. MI model was established ...
MiR-501-3p promotes osteosarcoma cell proliferation, migration and invasion by targeting BCL7A [0.03%]
miR-501-3p通过靶向BCL7A促进骨肉瘤细胞增殖、迁移和侵袭
Jinliang Dai,Lin Lu,Lixin Kang et al.
Jinliang Dai et al.
Increasing numbers of evidences have demonstrated that microRNAs (miRNAs) play an important role in osteosarcoma (OS) cell functions. MiR-501-3p has been reported to play an important role in several types of tumors, including prostate canc...