The Hippo pathway in cardiac fibrosis: mechanisms and therapeutic prospects [0.03%]
hippo信号通路在心脏纤维化中的作用机制及治疗前景
Yuting Qiu,Shanshan Hu,Hui Li et al.
Yuting Qiu et al.
Cardiac fibrosis is a prevalent pathological feature in the progression of various cardiovascular diseases, including heart failure, myocardial infarction, and dilated cardiomyopathy, particularly in their advanced stages. Its primary mecha...
Hsa_circ_0003176: a key player in the m6A modification-mediated regulation of autophagy and glycolysis in cisplatin-resistant non-small cell lung cancer [0.03%]
circRNA-Hsa_circ_0003176通过m６A修饰介导的自噬和糖酵解调控在顺铂耐药非小细胞肺癌中的作用研究
Sujuan Guo,Zhicheng Yang,Jiajie Qiao et al.
Sujuan Guo et al.
Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related mortality worldwide, with poor prognosis largely attributed to late-stage diagnosis and therapeutic resistance. Cisplatin (DDP) resistance is a major challenge in NSCLC...
Ethambutol induces optic neuropathy through SDHB-mediated ferroptosis in retinal ganglion cells via Smad4 pathway [0.03%]
乙胺丁醇通过Smad4信号通路介导的SDHB铁死亡诱导视网膜神经节细胞视神经病变
Qiushi Li,Wei Ge,Yifan Zhang et al.
Qiushi Li et al.
Ethambutol (EMB)-induced optic neuropathy (EON) is a clinical concern. Ferroptosis, involving iron and toxic reactive oxygen species (ROS), causes unique cell death, but its mechanism in EON is unclear. This study aims to explore the EON me...
Chebulagic acid targets FBXO38 to enhance natural killer cell-mediated anti-tumor immunity in lung adenocarcinoma [0.03%]
Chebulagic酸通过靶向FBXO38增强自然杀伤细胞介导的肺癌腺癌抗肿瘤免疫能力
Xiwen Hu,Rui Sha,Feiran Yang et al.
Xiwen Hu et al.
Lung adenocarcinoma (LUAD), the most prevalent and aggressive form of non-small cell lung cancer. Natural compounds have gained increasing attention as potential anti-cancer agents. The therapeutic potential of chebulagic acid (CA)-a hydrol...
Histone deacetylase 3 promotes hypoxia-induced human pulmonary arterial smooth muscle cell proliferation by modulating the CSF2-JAK2-STAT5 signaling pathway [0.03%]
组蛋白去乙酰酶3通过调节CSF2-JAK2-STAT5信号通路促进低氧诱导的人肺动脉平滑肌细胞增殖
Jie Zhang,Youfei Fan,Yanting Gao et al.
Jie Zhang et al.
The growth of human pulmonary arterial smooth muscle cells (hPASMCs) is one of the key contributors to vascular remodeling in pulmonary arterial hypertension (PAH). Although histone deacetylase 3 (HDAC3) has been implicated in acute lung in...
Generation and characterization of human iPSC lines (FAHZJUi001-A and FAHZJUi002-A) from two familial recurrent hydatidiform mole patients carrying homozygous mutation in the NLRP7 gene [0.03%]
来自NLRP7基因纯合子突变的两个复发性葡萄胎家系的人iPSC系（FAHZJUi001-A和FAHZJUi002-A）的建立与鉴定
Limeng Cai,Jiayang Wan,Yating Zhao et al.
Limeng Cai et al.
Hydatidiform mole (HM) is a pathological pregnancy characterized by excessive trophoblast proliferation and the absence of embryonic tissue development, predominantly sporadic in onset. Recurrent hydatidiform mole (RHM) affects approximatel...
Normal human cell strains characterized by the properties of mesenchymal stromal cells: implications for the fundamental features of cultured cells [0.03%]
具有间充质基质细胞特性的正常人类细胞系：对培养细胞基本特征的意义
Fumio Kasai,Keisuke Fukumoto,Kaoru Saijo et al.
Fumio Kasai et al.
Human cultured cells have been established from various normal and diseased tissues, serving as valuable in vitro cellular models. Normal cell strains play an important role in reference standards for human cells in in vitro experiments; ho...
The role of TLR2/MyD88/NF-κB pathway-mediated macrophage M1 polarization in recurrent spontaneous abortion associated with antiphospholipid syndrome [0.03%]
TLR2/MyD88/NF-κB通路介导的巨噬细胞M1极化在抗磷脂综合征复发性流产中的作用研究
Xiaolan Huang,Shuyin Zhang,Danhong Liang et al.
Xiaolan Huang et al.
The pathogenesis of recurrent miscarriage (RSA) is highly complex. Studies indicate that abnormal polarization of decidual macrophages is critical for pregnancy failure. The aim of this research is to investigate the function of M1 polariza...
A p53-responsive microRNA-100 released from cardiomyoblasts serves as an early biomarker for acute coronary syndrome [0.03%]
一种由心肌细胞释放的、可应对p53激活的miR-100在冠状动脉综合征早期诊断中的作用
Cheng-I Cheng,Ming-Huei Chou,Kuang-Den Chen et al.
Cheng-I Cheng et al.
Coronary artery disease, a leading cause of mortality, underscores the need for biomarkers that can predict acute coronary syndrome (ACS) occurrence and outcomes. MicroRNAs (miRNAs) are increasingly recognized as potential markers. This stu...
Potential of potentiometric biosensors for the study of ion influx and efflux via gasdermin pores in plasma membrane in pyroptosis: a hypothesis [0.03%]
关于潜在的电势生物传感器研究吡毒素中通过气导敏蛋白孔道进入和流出离子的可能性：一种假说
Caglar Berkel,Oguz Özbek,Onur Cem Altunoluk
Caglar Berkel