Establishment and characterization of a novel HBV-integrated hepatic sarcomatoid carcinoma cell line [0.03%]
Jiayin Dai,Fang Cao,Zhenli Yang et al.
Jiayin Dai et al.
Hepatic sarcomatoid carcinoma (HSC) is a rare and highly aggressive liver malignancy with an extremely poor prognosis. The lack of well-validated cellular models has severely limited mechanistic and translational research on this disease. I...
Culture-dependent baseline states and drug response programs in myxofibrosarcoma models across 2D and 3D systems [0.03%]
Yuki Yoshimatsu,Yomogi Shiota,Tadashi Kondo
Yuki Yoshimatsu
Myxofibrosarcoma (MFS) is a rare soft-tissue sarcoma with limited systemic therapy options, necessitating preclinical platforms that better simulate clinical drug responses. We investigated how 2D monolayers versus 3D spheroids shape the ba...
Generation of a human-induced pluripotent stem cell line from a retinitis pigmentosa patient carrying biallelic mutations in EYS gene [0.03%]
Jueun Kim,Juyeong Yu,Donghyun Kim et al.
Jueun Kim et al.
Retinitis pigmentosa (RP) is a hereditary retinal disorder characterized by progressive degeneration of photoreceptor cells in the retina, leading to gradual vision loss. Symptoms of RP typically begin with night blindness and progressive l...
Human peritoneal CCR2LowCRIgHigh macrophage subset exhibits embryonic origin-like phenotypes [0.03%]
Naofumi Takahashi,Sara A Habash,Yoshihiro Komohara et al.
Naofumi Takahashi et al.
Recent studies in mouse models have demonstrated that macrophages in adult tissues are maintained not only by the differentiation of bone marrow-derived monocytes but also by the proliferation of macrophages originating from the yolk sac or...
Pathogenesis and therapeutic strategies for neuropsychiatric lupus centered on innate immune activation [0.03%]
Wataru Nagata,Toshiaki Ishizuka
Wataru Nagata
Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious central nervous system complication of systemic lupus erythematosus (SLE) that markedly reduces patient quality of life. Despite its clinical importance, the underlying mech...
Extracellular vesicle-derived CDCP1 promotes chemoresistance and macrophage polarization in breast cancer [0.03%]
乳腺癌中外泌体来源的CDCP1促进化疗耐药及巨噬细胞极化
Yibing Liu,Li Ma,Ting Zhu et al.
Yibing Liu et al.
Breast cancer derived extracellular vesicles (EVs) mediate tumor progression through surface protein-dependent intercellular communication; however, their molecular heterogeneity remains poorly characterized. In this study, we employed a pr...
Exploring the role of protein homeostasis regulation in glycolysis in head and neck tumors [0.03%]
头颈部肿瘤中蛋白质稳态调节在糖酵解中的作用研究
Tian Xia,Kunya Jiang,Qinghong Huang et al.
Tian Xia et al.
Metabolic reprogramming is a hallmark of cancer. Tumor cells adapt to their environment by modulating glucose, lipid, and amino acid metabolism to supply raw materials for rapid growth and enhance treatment resistance. Among these, glucose ...
Pathological and therapeutic implications of Notch overexpression in claudin-low breast cancers [0.03%]
诺特宁过度表达在低紧密连接型乳腺癌中的病理和治疗意义研究
Reena Yadav,Sumit Goel,Deepinder Kaur et al.
Reena Yadav et al.
Claudin-low breast cancers (BCs), representing approximately 1.5-14% of all BCs, are characterized by high aggressiveness, enriched cancer stem cell (CSC) population, and poor prognosis. Despite the established role of Notch signaling in ma...
AKR1B10 drives hepatic steatosis and inflammation in metabolic dysfunction-associated steatotic liver disease via PI3K/AKT-mediated autophagy suppression [0.03%]
AKR1B10通过PI3K/AKT介导的自噬抑制驱动代谢功能障碍相关脂肪肝病中的肝脂变和炎症
Na Nie,Jing Tian,Xiaoyan Dong
Na Nie
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent metabolic disorder marked by excessive hepatic lipid accumulation, in which impaired autophagy plays a critical role. Aldo-keto reductase family 1 member B10 (A...