Deciphering the relevance of dead box RNA helicases in gliomagenesis and autophagy [0.03%]
解码死盒RNA解旋酶在胶质瘤发生和自噬中的作用
Arpit Sharma,Naveen Soni,Megha Chaudhary et al.
Arpit Sharma et al.
Dead-box RNA helicases (DDXs) are a family of proteins with roles in RNA metabolism, regulating processes such as RNA splicing, translation, and ribosome assembly. Recently, their functions have expanded to include essential roles in autoph...
Establishment of immortalized ovarian stromal cell lines using Sendai virus vectors: a platform for studying tumor-stroma interactions and carcinogenesis [0.03%]
利用仙台病毒载体建立卵巢间质细胞永生化细胞系：研究肿瘤-间质相互作用和致癌的平台
Masayo Okawa,Hiroaki Komatsu,Yasuhiro Kazuki et al.
Masayo Okawa et al.
We aimed to generate immortalized stromal cell lines from the ovarian and fallopian tube tissues of a single patient using Sendai virus (SeV) vectors and identify candidate stromal genes involved in ovarian carcinogenesis. Tissues were coll...
RMND5A upregulation via IGF2BP3-mediated m6A RNA modification enhances malignant traits and immune evasion in laryngeal squamous cell carcinoma cells [0.03%]
通过IGF2BP3介导的m6A RNA修饰上调的RMND5A增强喉部鳞状细胞癌细胞的恶性表型和免疫逃逸能力
Shu Zhang,Xiaojun Li,Miao Zhang et al.
Shu Zhang et al.
N6-methyladenosine (m6A) is the most prevalent mRNA internal modification in eukaryotic mRNAs and is frequently associated with progression and immune response in human cancers. This study delves into the function of m6A reader insulin like...
CDC6 promotes the development and progression of clear cell renal cell carcinoma via upregulating RRM2 [0.03%]
CDC6通过上调RRM2促进透明细胞肾细胞癌的发生发展
Tianpeng Xie,Zanxuan Deng,Youping Ding et al.
Tianpeng Xie et al.
Clear cell renal cell carcinoma (ccRCC) is the most common type of renal cell carcinoma, and exploration of its molecular mechanism benefits for developing more effective molecular targeted drugs. CDC6 has been found to be highly expressed ...
Mitophagy is responsible to ionizing radiation but plays a very limited role in the radiosensitivity of adenocarcinoma cells [0.03%]
线粒体自噬对放射敏感性的影响作用微弱
Chen Yan,Kai Huang,Yong Xu et al.
Chen Yan et al.
Radioresistance of adenocarcinoma cells limits the efficiency of radiotherapy. In addition to the cell nucleus, ionizing radiation (IR) also induces damage to the mitochondria. Mitophagy, a selective degradation of impaired mitochondria via...
Establishment and characterization of a novel cell line ICH-BCPALL-3 from B cell precursor acute lymphoblastic leukemia with TCF3::HLF [0.03%]
TCF3::HLF阳性B系急性淋巴细胞白血病新型细胞系ICH-BCPALL-3的建立与鉴定
Keisuke Kato,Ioannis Panagopoulos,Ai Yoshimi et al.
Keisuke Kato et al.
In vitro models of acute leukemia are crucial for understanding its biology and developing effective treatments. The authors have established and characterized a novel cell line, ICH-BCPALL-3, which expresses the TCF3::HLF fusion from B cel...
Effects of small extracellular vesicles isolated from pleural effusion on lung cancer cell proliferation and migration [0.03%]
胸水中小细胞外囊泡对肺癌细胞增殖和迁移的影响
G Cammarata,A Masucci,I Giusti et al.
G Cammarata et al.
Pleural effusion (PE) is a common clinical manifestation associated with advanced stages of both malignant and non-malignant diseases. PE frequently occurs in advanced non-small cell lung cancer (NSCLC) and contributes to tumor progression....
Establishment and characterization of a novel imatinib-resistant dermatofibrosarcoma protuberans cell line, DFSP-DPH1 [0.03%]
一种新型伊马替尼耐药的隆突性皮肤纤维肉瘤细胞系DFSP-DPH1的建立及鉴定
Hao Jiang,Kunqian He,Danli Li et al.
Hao Jiang et al.
Dermatofibrosarcoma protuberans (DFSP) is a rare, locally aggressive cutaneous sarcoma characterized by high recurrence rates and the development of resistance to imatinib. The scarcity of preclinical models hinders research into DFSP patho...
Interaction between gastric cancer organoids and peritoneal mesothelial cells suppresses the growth of gastric cancer organoids and induces drug resistance [0.03%]
胃癌类器官与腹膜间皮细胞互作抑制胃癌生长并诱导耐药性
Hiroyuki Uematsu,Shota Shimizu,Kunishige Onuma et al.
Hiroyuki Uematsu et al.
The prognosis of gastric cancer with peritoneal dissemination is poor because of its resistance to chemotherapy. To investigate the mechanism of drug resistance in peritoneal metastasis, cancer organoids were established from the ascites of...
ONECUT2-driven activation of ADAMTS14 boosts colorectal cancer stemness via Wnt pathway [0.03%]
ONECUT2通过Wnt信号激活ADAMTS14促进结直肠癌干细胞特性增强
Yicheng Jiang,Xingping Tan
Yicheng Jiang
The malignant progression of colorectal cancer (CRC) is closely related to cell stemness, but its regulatory mechanism has not been fully elucidated. This study found that ADAMTS14 was significantly highly expressed in CRC tissues and cell ...