Cedrol impedes lung cancer metastasis by reducing tumor-associated macrophage polarization mediated by MYC-driven aerobic glycolysis [0.03%]
CEDROL通过抑制MYC驱动的有氧糖酵解介导的肿瘤相关巨噬细胞极化来阻止肺癌转移
Qingsheng Li,Yuxi Liu,Lin Zhang et al.
Qingsheng Li et al.
The occurrence of tumor metastasis is associated with the phenotype of tumor-associated macrophages (TAMs). Within the tumor microenvironment, TAMs undergo metabolic reprogramming. Aerobic glycolysis contributes to TAM polarization into an ...
Multifaceted roles of microbiota-derived deoxycholic acid in gastrointestinal cancers: from barrier disruption to therapeutic implications [0.03%]
肠道微生物群衍生的脱氧胆酸在胃肠道癌症中的多面角色：从屏障破坏到治疗意义
Hai Zhao,Fan Yang,Jiaxin Yang et al.
Hai Zhao et al.
Deoxycholic acid (DCA), a microbial-derived secondary bile acid, plays a multifunctional role in gastrointestinal (GI) carcinogenic through various molecular and cellular mechanisms. Mechanistically, DCA causes disruption of epithelial barr...
Establishment of human histiocytic sarcoma organoids dependent on the SHH/YAP pathway [0.03%]
依赖SHH/YAP途径的人类组织细胞肉瘤器官样培养的建立
Yusuke Yoshimura,Keiichi Yoshida,Yukiko Matsuoka et al.
Yusuke Yoshimura et al.
Histiocytic sarcoma is an extremely rare and aggressive malignant neoplasm characterized by immunophenotypic features of mature histiocytes. The mechanisms underlying its malignant transformation remain poorly understood; consequently, the ...
Single-cell transcriptome analysis highlights a critical role of ATG5 for endothelial cells in diabetic nephropathy [0.03%]
单细胞转录组分析强调ATG5在糖尿病肾病内皮细胞中的关键作用
Yun Zhang,Lishuang Che,Hanyuan Gao et al.
Yun Zhang et al.
This study analyzed diabetic nephropathy (DN)-related single-cell RNA sequencing (scRNA-seq) data from public databases and dissected the mechanism by which the sirtuin 1 (SIRT1)/autophagy-related 5 (ATG5) axis mediates high glucose (HG)-in...
Multi-omic analysis constructs ferroptosis subtypes and risk signature and reveals that PEBP1 is an important tumor suppressor in kidney cancer [0.03%]
多组学分析构建铁死亡亚型和风险标志，并揭示PEBP1是肾癌中的重要抑癌基因
Shuaiqi Chen,Xizi Cheng,Zeyu Li et al.
Shuaiqi Chen et al.
Ferroptosis, an iron-dependent type of regulated cell death driven by excessive lipid peroxidation, plays an important role in natural tumor suppression. In this study, we identified 23 ferroptosis-related genes associated with prognosis in...
Emerging role of the E3 ubiquitin ligase RNF114 in health and disease [0.03%]
E3泛素连接酶RNF114在生命与疾病中的作用初探
Qian Wang,Shihan Cao,Zhenzhen Sun et al.
Qian Wang et al.
Ubiquitination plays important roles in various biological processes and diseases by affecting the subcellular localization, function, and degradation of substrates. Multiple ubiquitin-associated enzymes jointly mediate the binding of ubiqu...
Elucidating the risk factors and oncogene drivers of acute myeloid leukemia [0.03%]
阐明急性髓系白血病的风险因素及致癌驱动基因
Daniel Ruben Akiola Sanya,Djamila Onésime
Daniel Ruben Akiola Sanya
The hematopoietic system is critical for maintaining physiological homeostasis but is also implicated in various pathologies. The magnitude of hematopoietic responses to perturbations or diseases exhibits significant inter-individual variab...
ZWINT down-regulated by miR-495-3p inhibited lung metastasis of breast cancer by blocking p38 MAPK signaling pathway activation [0.03%]
miR-495-3p通过抑制p38 MAPK信号通路激活下调ZWINT从而抑制乳腺癌肺转移
Ming-Tao Shao,Wei-Wen Li,Yong Li et al.
Ming-Tao Shao et al.
Breast cancer metastasis is the primary cause of patient mortality, yet effective therapeutic targets remain limited. Building on our prior identification of ZWINT as a prognostic marker linked to metastasis, this study defines its critical...
Yusuke Nishimura
Yusuke Nishimura
Podocytes are highly specialized epithelial cells that are essential for maintaining the glomerular filtration barrier. They originate from the metanephric mesenchyme during kidney development, with differentiation tightly regulated by tran...
METTL14 knockdown augmented the polarization of M2-like macrophages to promote acute myeloid leukemia progression [0.03%]
METTL14缺失通过促进M2型巨噬细胞极化来促进急性髓系白血病进展
Meng Wang,Zhibin Xie,Yuanyuan Tan et al.
Meng Wang et al.
Within the m6A methyltransferase complex, methyltransferase-like 14 (METTL14) constitutes a pivotal component. This study aims to elucidate the role of METTL14 in macrophage differentiation and its involvement in the progression of acute my...