Establishment of a ZFP64::NCOA3 fusion-positive spindle cell/sclerosing rhabdomyosarcoma organoid model and evaluation of fusion-gene dependency [0.03%]
建立ZFP64::NCOA3融合阳性肌纤维母细胞型/硬化性横纹肌肉瘤器官模型并评估其对融合基因的依赖性
Ryota Miyamoto,Keiichi Yoshida,Yukiko Matsuoka et al.
Ryota Miyamoto et al.
Spindle cell/sclerosing rhabdomyosarcoma (SRMS) comprises a heterogeneous group of tumors characterized by distinct molecular alterations and clinical behaviors. Among them, ZFP64::NCOA3 fusion-positive SRMS represents an extremely rare sub...
Establishment and functional characterization of an EGFR-amplified tumoroid from squamous cell carcinoma of unknown primary [0.03%]
建立并功能表征来自未知原发灶的鳞状细胞癌的EGFR扩增肿瘤体
Miki Iwai,Etsuko Yokota,Takuro Yukawa et al.
Miki Iwai et al.
Carcinoma of unknown primary (CUP) remains a clinically challenging malignancy with limited treatment options and poor prognosis. Although genomic profiling has identified potentially actionable alterations, optimal therapeutic strategies a...
Integrative bulk and single-cell transcriptomics identify a recurrence-prognostic risk model with exploratory associations with treatment-response phenotypes in colorectal cancer [0.03%]
整合大规模和单细胞转录组识别结直肠癌复发预后风险模型及其与治疗反应表型的探究性关联
Shuai Li,Jingxian Li,Xianyue Bu et al.
Shuai Li et al.
Chemoresistance remains a major obstacle to improving outcomes in colorectal cancer (CRC), particularly among patients receiving 5-fluorouracil (5-FU)-based therapy. Here, we developed a READ-derived response-associated gene signature for r...
Correction: The dynamic evolution of circulating tumor cells during glecirasib treatment predicts survival and resistance in gastrointestinal tumors with KRASG12C mutation [0.03%]
纠正：glecirasib治疗期间循环肿瘤细胞的动态演变可预测KRASG12C突变型消化道肿瘤患者的生存和耐药性
Lei Jiang,Yiming Luo,Huan Liang et al.
Lei Jiang et al.
Published Erratum
Human cell. 2026 Aug 12;39(8):124. DOI:10.1007/s13577-026-01434-9 2026
A novel tRNA-derived fragment, tRF-19-79MP9PJZ, promotes uterine corpus endometrial carcinoma progression by targeting DSC3 [0.03%]
一种新型tRNA衍生片段tRF-19-79MP9PJZ通过靶向DSC3促进子宫体子宫内膜癌进展
Huabo Jiang,Ting Jiang,Yuting Shen et al.
Huabo Jiang et al.
Uterine corpus endometrial carcinoma (UCEC) ranks as the 6th most common malignancy among women. Emerging evidence indicates that the dysregulation of tRNA-derived fragments (tRFs) is involved in the pathogenesis of multiple cancer types, i...
HIPK2 exhibits context dependent dualistic effects and combinatorial inhibition of HIPK2-NLK-MAPK11 axis manifests synergism against gastric cancer [0.03%]
HIPK2表现出依赖于背景的双重效应，并且抑制HIPK2-NLK-MAPK11轴线会针对胃癌产生协同作用
Aathithya Rangarajan,Thirumoorthi Natarajan,Sujatha Lakshminarayanan et al.
Aathithya Rangarajan et al.
Homeodomain-interacting protein kinase 2 (HIPK2) can function either as a tumour suppressor or promoter in cancer. Understanding key features of HIPK2 context dependent effects in cancer could lead to novel therapeutic strategies. Our inves...
Yongchang Xu,Ziyu Liu,Xiaofeng Li
Yongchang Xu
Regular physical exercise can induce a multifaceted cardioprotective phenotype characterized by improved Ca2⁺ handling, mitochondrial resilience, redox buffering, autonomic regulation, and resistance to ischemia-reperfusion injury. Ca2⁺/c...
Colorectal cancer-derived exosomal ETS2 promotes macrophage M2 polarization by transcriptionally activating PRPF4 [0.03%]
结直肠癌来源的外泌体ETS2通过转录激活PRPF4促进巨噬细胞M2极化
Dengfeng Hou,Zhongyuan Bai,Jiaxin Zhao et al.
Dengfeng Hou et al.
Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, with tumor-associated macrophages (TAMs), predominantly M2-polarized, shaping a tumor-promoting microenvironment. ETS proto-oncogene 2 (ETS2) is aberrantly up...
Cytotoxic and genotoxic effects of oxime β-lapachone in human cancer cells: selectivity toward NCI-H460 and insights from molecular docking [0.03%]
恶姻β-拉帕醌对人类癌细胞细胞毒和遗传毒性作用：NCI-H460的选择性及分子对接启示
Maria Francilene Souza Silva,Lara Polyana Silva Ramos,Fátima de Cássia Evangelista de Oliveira et al.
Maria Francilene Souza Silva et al.
β-Lapachone exhibits potent anticancer activity although its clinical application remains limited by toxicity and mechanisms of resistance. Therefore, structural modifications have been explored to improve its pharmacological profile. This...