Screening of pivotal oncogenes modulated by DNA methylation in hepatocellular carcinoma and identification of atractylenolide I as an anti-cancer drug [0.03%]
肝细胞癌中DNA甲基化调控的关键原癌基因的筛选及鉴定白术内酯I为抗肿瘤药物
Yang Zhi,Tong Qiaoyun
Yang Zhi
This study was performed to identify crucial oncogenes modulated by DNA methylation in hepatocellular carcinoma (HCC) and look for new drugs for HCC treatment. The data of TCGA-LIHC cohort were obtained from UCSC database. Weighted gene co-...
Deficiency of synaptotagmin-1 aggravates pressure overload-induced cardiac hypertrophy and dysfunction via the p38 MAPK signaling pathway in mice [0.03%]
突触素-1缺乏通过p38丝裂原活化蛋白激酶信号途径加重小鼠压力超负荷诱导的心肌肥厚和心功能障碍
Jing Shen,Junqiu Miao,Lifei Wu et al.
Jing Shen et al.
Cardiac hypertrophy is a major risk factor for heart failure and sudden cardiac death, but its molecular mechanisms have not been well clarified. Synaptotagmin-1 (SYT1) is an important regulator of exocytosis and apoptosis and has been foun...
Generation of human induced pluripotent stem cell lines derived from a patient carrying an intragenic deletion in the NFIA gene [0.03%]
来源于NFIA基因内缺失携带者的人诱导多能干细胞系的建立
Ning Zhou,Shengnan Zhang,Chunli Wang et al.
Ning Zhou et al.
Brain malformations with or without urinary tract defects (BRMUTD) are caused by heterozygous variants in the NFIA gene. BRMUTD is a neurodevelopmental disorder characterized by hypoplasia or absence of the corpus callosum, hydrocephalus or...
Case Reports
Human cell. 2025 Apr 23;38(3):95. DOI:10.1007/s13577-025-01222-x 2025
Retraction Note: RCC2 contributes to tumor invasion and chemoresistance to cisplatin in hepatocellular carcinoma [0.03%]
撤回 notice: RCC2 在肝细胞癌侵袭和顺铂耐药中的作用
Qingmin Chen,Peiqiang Jiang,Baoxing Jia et al.
Qingmin Chen et al.
Establishment and characterization of NCC-PS2-C1: a novel cell line of high-grade pleomorphic spindle cell sarcoma, most consistent with myxofibrosarcoma [0.03%]
NCC-PS2-C1新型高级别多形性梭形细胞肉瘤细胞系的建立与鉴定（最符合黏液纤维肉瘤）
Shuhei Iwata,Rei Noguchi,Julia Osaki et al.
Shuhei Iwata et al.
Pleomorphic sarcoma (PS) is a heterogeneous group of malignant mesenchymal tumors that lack specific histological differentiation. PS is characterized by genetic instability and diversity and unique histological features such as pronounced ...
Hyaluronic acid-modified milk exosomes carrying ZNF516 inhibit ABCC5 and contribute to pemetrexed sensitivity in lung adenocarcinoma [0.03%]
透明质酸修饰的乳外泌体递送ZNF516抑制ABCC5并增敏肺腺癌患者培美曲塞治疗效果
Hui Li,Yanyan Sun,Jue Wang et al.
Hui Li et al.
Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer. Milk-derived exosomes (mEXOs) have critical roles in cancer treatment. This paper explores the effects of hyaluronic acid (HA)-modified mEXOs (HA-mEXOs) in LUAD. HA-mEXOs...
LncRNA OLMALINC promotes osteosarcoma progression through USP1-mediated autophagy suppression [0.03%]
长链非编码RNA OLMALINC通过去泛素酶USP1介导的自噬抑制促进骨肉瘤进展
Jianping Li,Bo Yu,Zhaowen Xue et al.
Jianping Li et al.
Osteosarcoma (OS) remains a challenging malignancy with poor prognosis, especially in metastatic or recurrent cases. Despite progress, the molecular mechanisms driving OS, particularly the regulation of autophagy, are not fully understood. ...
Clinical characteristics and induced pluripotent stem cells (iPSCs) disease model of Harel-Yoon syndrome caused by compound heterozygous ATAD3A variants [0.03%]
ATAD3A复合杂合变异导致的Harel-Yoon综合征的临床特征及诱导多能干细胞(iPSCs)疾病模型研究
Ziyi Jiang,Hongyu Chen,Xianghong Zhang et al.
Ziyi Jiang et al.
ATPase family AAA-domain-containing protein 3 A (ATAD3A) is enriched on the mitochondrial membrane and is essential to the maintenance of mitochondrial structure and function. Variants of the ATAD3A gene can lead to Harel-Yoon syndrome (HAY...
The role of MICAL2 in cancer progression: mechanisms, challenges, and therapeutic potential [0.03%]
MICAL2在癌症进展中的作用：机制、挑战及治疗潜力
Ruiying Wang,Zhijuan Hou,Xiao Gao et al.
Ruiying Wang et al.
Cancer is the greatest threat to public health worldwide and a major cause of human death. Compared with conventional chemotherapy, agents targeting key oncogenic drivers and signaling mechanisms are becoming an attractive treatment strateg...
SIX1 enhances aerobic glycolysis and progression in cervical cancer through ENO1 [0.03%]
SIX1通过ENO1促进宫颈癌的糖酵解和进展
Xuelian Liu,Hang Ren,Anjin Wang et al.
Xuelian Liu et al.
Cervical cancer is a significant threat to women's health, and its incidence in China has been increasing in recent years. Treating advanced and recurrent cervical cancer has become increasingly challenging, highlighting the urgent need to ...