Multi-omic analysis constructs ferroptosis subtypes and risk signature and reveals that PEBP1 is an important tumor suppressor in kidney cancer [0.03%]
多组学分析构建铁死亡亚型和风险标志，并揭示PEBP1是肾癌中的重要抑癌基因
Shuaiqi Chen,Xizi Cheng,Zeyu Li et al.
Shuaiqi Chen et al.
Ferroptosis, an iron-dependent type of regulated cell death driven by excessive lipid peroxidation, plays an important role in natural tumor suppression. In this study, we identified 23 ferroptosis-related genes associated with prognosis in...
Emerging role of the E3 ubiquitin ligase RNF114 in health and disease [0.03%]
E3泛素连接酶RNF114在生命与疾病中的作用初探
Qian Wang,Shihan Cao,Zhenzhen Sun et al.
Qian Wang et al.
Ubiquitination plays important roles in various biological processes and diseases by affecting the subcellular localization, function, and degradation of substrates. Multiple ubiquitin-associated enzymes jointly mediate the binding of ubiqu...
Elucidating the risk factors and oncogene drivers of acute myeloid leukemia [0.03%]
阐明急性髓系白血病的风险因素及致癌驱动基因
Daniel Ruben Akiola Sanya,Djamila Onésime
Daniel Ruben Akiola Sanya
The hematopoietic system is critical for maintaining physiological homeostasis but is also implicated in various pathologies. The magnitude of hematopoietic responses to perturbations or diseases exhibits significant inter-individual variab...
ZWINT down-regulated by miR-495-3p inhibited lung metastasis of breast cancer by blocking p38 MAPK signaling pathway activation [0.03%]
miR-495-3p通过抑制p38 MAPK信号通路激活下调ZWINT从而抑制乳腺癌肺转移
Ming-Tao Shao,Wei-Wen Li,Yong Li et al.
Ming-Tao Shao et al.
Breast cancer metastasis is the primary cause of patient mortality, yet effective therapeutic targets remain limited. Building on our prior identification of ZWINT as a prognostic marker linked to metastasis, this study defines its critical...
Yusuke Nishimura
Yusuke Nishimura
Podocytes are highly specialized epithelial cells that are essential for maintaining the glomerular filtration barrier. They originate from the metanephric mesenchyme during kidney development, with differentiation tightly regulated by tran...
METTL14 knockdown augmented the polarization of M2-like macrophages to promote acute myeloid leukemia progression [0.03%]
METTL14缺失通过促进M2型巨噬细胞极化来促进急性髓系白血病进展
Meng Wang,Zhibin Xie,Yuanyuan Tan et al.
Meng Wang et al.
Within the m6A methyltransferase complex, methyltransferase-like 14 (METTL14) constitutes a pivotal component. This study aims to elucidate the role of METTL14 in macrophage differentiation and its involvement in the progression of acute my...
Eucommia ulmoides (Duzhong) extract alleviates cerebral stroke by inhibiting ferroptosis-related gene DNA Damage-Inducible Transcript 4 (DDIT4) expression [0.03%]
杜仲叶提取物通过抑制铁死亡相关基因DNA损伤诱导转录4（DDIT4）表达缓解脑卒中
Xin Qi,Mengyuan Deng,Minhong Li et al.
Xin Qi et al.
Cerebral stroke is an acute cerebrovascular disease, which is characterized by significant morbidity, death, and disability rate. Ischemic stroke is more than hemorrhagic stroke and accounts for 60-70% of all strokes. The present study expl...
Hofbauer cell alterations and potential role in the pathophysiology of HELLP syndrome [0.03%]
hofbauer细胞改变与HELLP综合征发病机制的潜在作用
Ayano Ezaki,Akihito Sagara,Yoshihiro Komohara et al.
Ayano Ezaki et al.
HELLP syndrome, a severe pregnancy complication characterized by hemolysis, elevated liver enzymes, and low platelet count, is a subtype of preeclampsia (PE). However, its rapid onset and unique clinical features suggest distinct underlying...
Exportin-1 and epigenetic modifications interaction: more than nuclear transport [0.03%]
出口蛋白1与表观遗传修饰的相互作用：不仅仅是核运输
Leonidas Benetatos,Eleftheria Hatzimichael,Eleni Kapsali
Leonidas Benetatos
Exportin-1 (XPO1) is fundamental in the regulation of nuclear-to-cytoplasm transportation. XPO1 has the ability to transport hundreds of proteins and several different types of mRNAs responsible for proper cellular biology. Deregulation of ...
Generation of human induced pluripotent stem cell lines derived from Wolf-Hirschhorn syndrome patients with chromosomal 4p deletion [0.03%]
由4号染色体短臂缺失的Wolf-Hirschhorn综合征患者诱导的多能干细胞系的建立
Tomoya Shimizu,Miho Takami,Mami Matsuo-Takasaki et al.
Tomoya Shimizu et al.
Wolf-Hirschhorn syndrome (WHS) is a devastating congenital disease caused by deletions on the short arm of chromosome 4 (4p), for which no curative treatments currently exist. To facilitate the development of therapeutic strategies, the dev...