Long non-coding RNA nuclear paraspeckle assembly transcript 1 promotes activation of T helper 2 cells via inhibiting STAT6 ubiquitination [0.03%]
长非编码RNA核副斑装配转录物1通过抑制STAT6泛素化促进T辅助细胞2的活化
Shuman Huang,Dong Dong,Yaqian Zhang et al.
Shuman Huang et al.
T helper (Th) 2 cell-medicated immune response participates in various immune diseases, including systemic lupus erythematosus (SLE). Long non-coding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) has been reported to be associated w...
Characterization of stem cells from human ovarian follicular fluid; a potential source of autologous stem cell for cell-based therapy [0.03%]
人卵泡液干细胞的特征研究；一种基于细胞疗法的自身干细胞潜在来源
Ruttachuk Rungsiwiwut,Pranee Numchaisrika,Paweena Thuwanut et al.
Ruttachuk Rungsiwiwut et al.
Human ovarian follicular fluid (HOFF) contains proteins, extracellular matrixes necessary for growth and maturation of oocytes as well as granulosa cells. Epithelial cells and stem cells can be isolated from HOFF. However, information regar...
Morphological and biochemical changes in the pancreas associated with acute systemic hypoxia [0.03%]
急性全身缺氧相关的胰腺形态和生化改变
Fumiya Morioka,Naoto Tani,Tomoya Ikeda et al.
Fumiya Morioka et al.
This study aimed to investigate the changes associated with acute systemic hypoxia in the endocrine system, particularly in pancreatic tissues. The investigation was based on macroscopic, pathohistological, biochemical, and molecular biolog...
Morteza Ghasemnejad-Berenji
Morteza Ghasemnejad-Berenji
The current COVID-19 is one of the deadliest pandemics in recent decades. In the lack of a specific treatment for this novel infection, knowing the role of cell signaling pathways in the pathogenesis of this infection could be useful in fin...
Both variants of A1CF and BAZ1B genes are associated with gout susceptibility: a replication study and meta-analysis in a Japanese population [0.03%]
基于日本人群的验证及荟萃分析研究A1CF和BAZ1B基因多态性与痛风易感性的关联
Makoto Kawaguchi,Akiyoshi Nakayama,Yuka Aoyagi et al.
Makoto Kawaguchi et al.
Gout is a common type of acute arthritis that results from elevated serum uric acid (SUA) levels. Recent genome-wide association studies (GWASs) have revealed several novel single nucleotide polymorphism (SNPs) associated with SUA levels. O...
Meta-Analysis
Human cell. 2021 Mar;34(2):293-299. DOI:10.1007/s13577-021-00485-4 2021
Amr Ahmed El-Arabey,Mohnad Abdalla,Adel Rashad Abd-Allah
Amr Ahmed El-Arabey
Elevated levels of expression of cytochrome P450 3A4 in a human liver epithelial cell line in differentiation-inducing conditions [0.03%]
人肝上皮细胞系中，在诱导分化的培养条件下药物代谢酶细胞色素P450 3A4表达水平升高
Taisuke Yamazaki,Takayoshi Tokiwa
Taisuke Yamazaki
Cytochrome P450 (CYP) enzymes, especially CYP3A4 play a major role in the metabolism of xenobiotics in human liver. CYP3A4-expressing human liver or hepatoma cell lines may be good cell substitutes of human hepatocytes for drug metabolism s...
ACE2 mutation might explain lower COVID-19 burden in malaria endemic areas [0.03%]
恶性疟流行地区新冠肺炎负担较低或与ACE2基因突变有关
Auley De,Aparna Tiwari,Manoswini Dash et al.
Auley De et al.
Targeted deletion of HAI-1 increases prostasin proteolysis but decreases matriptase proteolysis in human keratinocytes [0.03%]
人类角质形成细胞中靶向删除HAI-1增加prostasin的蛋白水解但减少matriptase的蛋白水解
Dajun D Lu,Yayun Gu,Sheng-Wen A Li et al.
Dajun D Lu et al.
Epidermal differentiation and barrier function require well-controlled matriptase and prostasin proteolysis, in which the Kunitz-type serine protease inhibitor HAI-1 represents the primary enzymatic inhibitor for both proteases. HAI-1, howe...
RING-finger protein 5 promotes hepatocellular carcinoma progression and predicts poor prognosis [0.03%]
含环指指蛋白5促进肝癌进展及预示不良预后
Yi Zhang,Jie Li,Huayang Chen et al.
Yi Zhang et al.
Hepatocellular carcinoma (HCC) is one of the most common cause of malignancy-related deaths. Recently, RING-finger protein 5 (RNF5), an E3 ubiquitin ligase, was revealed to be associated with the development of several human cancers. Howeve...