The glycocalyx: a key target for treatment of severe acute pancreatitis-associated multiple organ dysfunction syndrome [0.03%]
糖萼：重症急性胰腺炎相关多器官功能障碍综合征治疗的关键靶点
Huijuan Li,Haiyun Wen,Jie Liu et al.
Huijuan Li et al.
The endothelial glycocalyx is a dynamic brush-like layer composed of proteoglycans and glycosaminoglycans, including heparan sulfate (HS) and hyaluronic acid (HA), and is an important regulator of vascular homeostasis. Its structure (thickn...
KDELR3 is transcriptionally activated by FOXM1 and accelerates lung adenocarcinoma growth and metastasis via inhibiting endoplasmic reticulum stress-induced cell apoptosis [0.03%]
FOXM1转录激活的KDELR3通过抑制内质网应激诱导的细胞凋亡促进肺腺癌生长和转移
Cheng Wang,Zhaoxuan Wang,Shiqing Wang et al.
Cheng Wang et al.
Lung cancer is still considered to be the leading cause of cancer-related death worldwide, and lung adenocarcinoma (LUAD) is the most common kind. KDEL Endoplasmic Reticulum Protein Retention Receptor 3 (KDELR3) is a critical regulator of t...
Secretory pathway in honeybee venom and actin: evidence from chemical-biological interactions [0.03%]
与蜂毒和肌动蛋白的化学-生物学相互作用相关的分泌途径研究
Amr Ahmed El-Arabey
Amr Ahmed El-Arabey
ITGA5 drives angiogenesis in diabetic retinopathy via TAK-1/NF-kB activation [0.03%]
ITGA5通过TAK-1/NF-κB激活驱动糖尿病视网膜病变的新生血管生成
Feifei Kan,Di Wang,Sijia Li et al.
Feifei Kan et al.
Diabetic retinopathy is a retinal damage, which causes vision impairment and blindness. Integrin Subunit Alpha 5 (ITGA5) regulates angiogenic response, but its roles in diabetic retinopathy remain unclear. In this work, diabetes mellitus wa...
Establishment and characterization of patient-derived tongue squamous cell carcinoma cell lines [0.03%]
建立并表征源自患者的舌鳞状细胞癌细胞系
Priyanka Joshi,Sanjay Bane,Pankaj Chaturvedi et al.
Priyanka Joshi et al.
Oral squamous cell carcinoma (OSCC) is a common carcinoma in Indian population, wherein one-third of global OSCC cases are from India. The five-year survival rate is poor due to late diagnosis. Oral tongue squamous cell carcinoma (OTSCC) is...
The role of microglia in the development of diabetic retinopathy and its potential clinical application [0.03%]
小胶质细胞在糖尿病视网膜病变发病机制中的作用及其潜在临床应用价值
Tingting Lu,Jiameng Shang,Shengdan Pu et al.
Tingting Lu et al.
Lately, research on the function of microglia in diabetic retinopathy (DR) is becoming increasingly focused. Microglia are immune cells that dwell in the central nervous system and are crucial to the pathophysiology of DR. According to stud...
Sunitinib-resistant renal cell carcinoma cell-derived exosomes promote facilitation of tumor progression via secretion of the lncRNA SNHG16 [0.03%]
索拉非尼耐药肾癌细胞来源的外泌体通过分泌长链非编码 RNA SNHG16 促进肿瘤进展
WeiLijiang Saimaiti,Jun Ma,Paluoke Dilimulati et al.
WeiLijiang Saimaiti et al.
Renal cell carcinoma (RCC) is one of the most common tumors of high malignancy in the urological system. Sunitinib is commonly used to treat RCC, while drug resistance severely limited the therapeutic efficacy. Tumor-derived exosomes play i...
Advanced glycation end products alter the structural integrity, increase the permeability and transform the biocompatibility of collagen within the peritoneal membrane [0.03%]
advanced glycation end 产物改变腹膜胶原结构完整性、增加其通透性并转化其生物相容性
Makoto Fukuda,Yusuke Chiwata,Takayuki Narita et al.
Makoto Fukuda et al.
In patients undergoing long-term peritoneal dialysis, the peritoneal accumulation of advanced glycation end-products (AGEs) due to the Maillard reaction has long been acknowledged as problematic, although the underlying mechanisms remain in...
Establishment and characterization of Cri Du Chat neuronal stem cells: a novel promising resource to study the syndrome [0.03%]
克氏征神经干细胞的建立与鉴定：一种研究该综合症的新资源
Giovanna Piovani,Rosalba Monica Ferraro,Silvia Clara Giliani
Giovanna Piovani
The Cri Du Chat (CdC) Syndrome is a rare chromosome disease condition resulting from variable size deletion occurring on the short arm of one of the chromosomes 5. This disorder, which affects one in 50,000 births, is responsible for develo...