SerpinB1 reduces neutrophil airway inflammation, airway remodeling, and pyroptosis in asthmatic mice by interacting with Elane [0.03%]
通过与Elane相互作用，SerpinB1在哮喘小鼠中减少中性粒细胞气道炎症、气道重塑和细胞焦亡
Na Chen,Zhu Chen,LianKe Li et al.
Na Chen et al.
Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness, airway remodeling, and persistent inflammation, with neutrophilic phenotypes often associated with severe and steroid-resistant cases. SerpinB1, a serine ...
TPM3-NTRK1 fusion confers resistance to osimertinib in lung adenocarcinoma: a model in a continuous cell line [0.03%]
TPM3-NTRK1融合导致肺癌腺癌患者对奥希替尼耐药：连续细胞系中的模型研究
Fang Cao,Jiayin Dai,Kun Dong et al.
Fang Cao et al.
A 62-year-old woman with EGFR exon 19-mutant lung adenocarcinoma developed resistance to osimertinib after 13 months of treatment. At progression, genetic analysis revealed persistence of the EGFR mutation and acquisition of a TPM3-NTRK1 fu...
Case Reports
Human cell. 2025 Oct 28;38(6):182. DOI:10.1007/s13577-025-01315-7 2025
Overexpression of miR-454-3p inhibits high glucose-induced ET-1 expression, leading to eNOS upregulation in endothelial cells: an integrated bioinformatics and experimental analysis [0.03%]
高糖诱导的内皮细胞ET-1表达上调通过miR-454-3p/eNOS信号轴调节的作用及机制研究
Weifang Li,Qiuwang Zhang,Michael J B Kutryk
Weifang Li
Endothelin-1 (ET-1) plays a critical role in diabetic vasculopathy. Although clinical trials have shown promise for ET-1 receptor antagonists in treating diabetic nephropathy, their clinical use remains limited by adverse effects. MiR-454-3...
Psoriasis and lichen planus: an immunohistochemical study of Trophoblast cell-surface antigen 2 expression in skin biopsies [0.03%]
银屑病和扁平苔藓：Trophoblast细胞表面抗原2在皮肤活检标本中的表达免疫组化研究
Giovanni Tossetta,Sonia Fantone,Alessandra Filosa et al.
Giovanni Tossetta et al.
Chronic plaque psoriasis (CPS) and lichen planus (LP) are two chronic, immune-mediated inflammatory skin conditions that often spontaneously heal, even if recurrence is common. In both diseases, the immune system mistakenly targets skin cel...
Long non-coding RNA FEZF1-AS1 suppresses ferroptosis in multiple myeloma cells through KIAA1429-mediated m6A modification [0.03%]
长非编码RNA FEZF1-AS1通过KIAA1429介导的m6A修饰抑制多发性骨髓瘤细胞铁死亡
Qing Su,Weiliang Liu,Peijin Wang et al.
Qing Su et al.
Multiple myeloma (MM) is a hematologic malignancy characterized by abnormal clonal plasma cells in the bone marrow. This study aims to investigate the mechanism by which the long non-coding RNA FEZF1 antisense RNA 1 (FEZF1-AS1) regulates fe...
Cedrol impedes lung cancer metastasis by reducing tumor-associated macrophage polarization mediated by MYC-driven aerobic glycolysis [0.03%]
CEDROL通过抑制MYC驱动的有氧糖酵解介导的肿瘤相关巨噬细胞极化来阻止肺癌转移
Qingsheng Li,Yuxi Liu,Lin Zhang et al.
Qingsheng Li et al.
The occurrence of tumor metastasis is associated with the phenotype of tumor-associated macrophages (TAMs). Within the tumor microenvironment, TAMs undergo metabolic reprogramming. Aerobic glycolysis contributes to TAM polarization into an ...
Multifaceted roles of microbiota-derived deoxycholic acid in gastrointestinal cancers: from barrier disruption to therapeutic implications [0.03%]
肠道微生物群衍生的脱氧胆酸在胃肠道癌症中的多面角色：从屏障破坏到治疗意义
Hai Zhao,Fan Yang,Jiaxin Yang et al.
Hai Zhao et al.
Deoxycholic acid (DCA), a microbial-derived secondary bile acid, plays a multifunctional role in gastrointestinal (GI) carcinogenic through various molecular and cellular mechanisms. Mechanistically, DCA causes disruption of epithelial barr...
Establishment of human histiocytic sarcoma organoids dependent on the SHH/YAP pathway [0.03%]
依赖SHH/YAP途径的人类组织细胞肉瘤器官样培养的建立
Yusuke Yoshimura,Keiichi Yoshida,Yukiko Matsuoka et al.
Yusuke Yoshimura et al.
Histiocytic sarcoma is an extremely rare and aggressive malignant neoplasm characterized by immunophenotypic features of mature histiocytes. The mechanisms underlying its malignant transformation remain poorly understood; consequently, the ...
Single-cell transcriptome analysis highlights a critical role of ATG5 for endothelial cells in diabetic nephropathy [0.03%]
单细胞转录组分析强调ATG5在糖尿病肾病内皮细胞中的关键作用
Yun Zhang,Lishuang Che,Hanyuan Gao et al.
Yun Zhang et al.
This study analyzed diabetic nephropathy (DN)-related single-cell RNA sequencing (scRNA-seq) data from public databases and dissected the mechanism by which the sirtuin 1 (SIRT1)/autophagy-related 5 (ATG5) axis mediates high glucose (HG)-in...