Potential of platelet-rich plasma-derived exosomes for bone-defect repair: in vitro and in vivo study [0.03%]
富血小板血浆衍生的外泌体促进骨缺损修复的潜力：基于体内外研究
Xuepu Zhang,Limin Yang,Yaguang Wang et al.
Xuepu Zhang et al.
Skeletal progenitor-enriched cells, also referred to as skeletal stem cell (SSC)-like cells, are multipotent progenitors that underpin advancements in bone bioengineering and regenerative therapy. Platelet-rich plasma-derived exosomes (PRP-...
Establishment and characterization of TK-DDCS1: a novel IDH1 mutated dedifferentiated chondrosarcoma cell line [0.03%]
TK-DDCS1细胞系的建立及鉴定：一株新型IDH1突变软骨肉瘤去分化细胞系
Krittamate Saisuwan,Piyanard Boonnate,Hiroki Goto et al.
Krittamate Saisuwan et al.
Dedifferentiated chondrosarcoma (DDCS) is a rare and aggressive subtype of chondrosarcoma, characterized by the coexistence of a high-grade spindle or pleomorphic tumor that lacks a substantial cartilaginous matrix. Notably, it shows a muta...
Establishment and comparison of three sublines from a human uterine carcinosarcoma cell line, ESCA [0.03%]
从人子宫癌肉瘤细胞系ESCA建立并比较其三个亚系
Yixiu Long,Xuan Pei,Hongyu Liu et al.
Yixiu Long et al.
The pathogenesis of uterine carcinosarcoma (UCS) remains unclear due to a few mature cell lines. Herein, we established a new cell line, ESCA, from a Chinese woman. Especially, three sublines, named ESCA-2, ESCA-3, ESCA-5, were isolated bas...
Comparative Study
Human cell. 2025 Jun 2;38(4):115. DOI:10.1007/s13577-025-01225-8 2025
Hypoxic breast cancer cell-derived exosomal miR-143-3p targets RICTOR to regulate M2 macrophage polarization, thereby modulating cancer cell invasiveness [0.03%]
缺氧乳腺癌细胞来源的外泌体miR-143-3p靶向RICTOR调节M2型巨噬细胞极化并调控癌症细胞侵袭性
Hongyu Lian,Miao Yu,Qi Li et al.
Hongyu Lian et al.
Hypoxia is a critical mechanism within the microenvironment of tumors. Exosomes, serve as conduits for intercellular communication and transport the biomolecule miRNA by facilitating intercellular signal exchange, which partially regulate c...
Biological functions and molecular mechanisms of circHIPK3 in digestive system tumors [0.03%]
circHIPK3在消化系统肿瘤中的生物学功能及分子机制研究进展
Jian Li,Xin Su,Xiao Xu et al.
Jian Li et al.
Digestive system tumors are the most common tumors worldwide with high mortality rates. Circular homeodomain-interacting protein kinase 3 (circHIPK3) is a highly abundant and stable circular RNA and have garnered significant attention in th...
Takamichi Ito,Yuka Tanaka,Keiko Tanegashima et al.
Takamichi Ito et al.
Nail apparatus melanoma (NAM) is a specific type of cutaneous melanoma that develops in the nail apparatus of the hands and feet. The prognosis for metastatic NAM is poor due to a lack of fully effective systemic therapies. However, the dif...
Case Reports
Human cell. 2025 May 28;38(4):112. DOI:10.1007/s13577-025-01242-7 2025
Mesenchymal stem/stromal cells-derived exosomes: possible therapeutic mechanism in inflammatory bowel disease [0.03%]
间充质干细胞来源的外泌体在炎症性肠病治疗中的可能机制研究
Zekun Li,Luyun Liu,Yuhui Sun et al.
Zekun Li et al.
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract caused by dysfunction of the immune system in genetically susceptible individuals. As current pharmacologic and surgical treatments remain sub...
Single-cell dynamic RNA and glycosylation sequencing reveals the mechanism underlying the differentiation of pluripotent stem cells into hematopoietic stem cells [0.03%]
单细胞动态RNA及糖基化测序揭示多能干细胞分化为造血干细胞的机制
Wanyi Feng,Sheng Zeng,Donghui Liu et al.
Wanyi Feng et al.
Studying the mechanism of hematopoietic stem cells' generation from induced pluripotent stem cells in vitro can be useful for understanding embryonic hematopoiesis, as well as for the application of related cell therapy. This study aimed to...
Establishment and characterization of NCC-MLPS4-C1: a novel patient-derived cell line of myxoid liposarcoma [0.03%]
NCC-MLPS4-C1新型黏液样脂肪肉瘤患者源细胞系的建立与鉴定
Julia Osaki,Rei Noguchi,Takuya Ono et al.
Julia Osaki et al.
Myxoid liposarcoma (MLPS) is a malignant tumor composed of uniform, round-to-ovoid cells and small lipoblasts embedded in a myxoid stroma containing branching capillaries. MLPS is characterized by the presence of fusion genes, primarily FUS...
Establishment and molecular characterization of the novel cutaneous squamous cell carcinoma cell line from advanced-stage Indian patient [0.03%]
建立并分子表征来自晚期印度患者的新型皮肤鳞状细胞癌细胞系
Darshan Mehta,Akshay Paradkar,Prakash Nayak et al.
Darshan Mehta et al.
Cutaneous squamous cell carcinoma (CSCC) is the second most prevalent skin cancer with low metastatic potential; it poses significant morbidity challenges. CSCC possesses significant heterogeneity and the treatment presents a formidable cha...