Effects of small extracellular vesicles isolated from pleural effusion on lung cancer cell proliferation and migration [0.03%]
胸水中小细胞外囊泡对肺癌细胞增殖和迁移的影响
G Cammarata,A Masucci,I Giusti et al.
G Cammarata et al.
Pleural effusion (PE) is a common clinical manifestation associated with advanced stages of both malignant and non-malignant diseases. PE frequently occurs in advanced non-small cell lung cancer (NSCLC) and contributes to tumor progression....
Establishment and characterization of a novel imatinib-resistant dermatofibrosarcoma protuberans cell line, DFSP-DPH1 [0.03%]
一种新型伊马替尼耐药的隆突性皮肤纤维肉瘤细胞系DFSP-DPH1的建立及鉴定
Hao Jiang,Kunqian He,Danli Li et al.
Hao Jiang et al.
Dermatofibrosarcoma protuberans (DFSP) is a rare, locally aggressive cutaneous sarcoma characterized by high recurrence rates and the development of resistance to imatinib. The scarcity of preclinical models hinders research into DFSP patho...
Interaction between gastric cancer organoids and peritoneal mesothelial cells suppresses the growth of gastric cancer organoids and induces drug resistance [0.03%]
胃癌类器官与腹膜间皮细胞互作抑制胃癌生长并诱导耐药性
Hiroyuki Uematsu,Shota Shimizu,Kunishige Onuma et al.
Hiroyuki Uematsu et al.
The prognosis of gastric cancer with peritoneal dissemination is poor because of its resistance to chemotherapy. To investigate the mechanism of drug resistance in peritoneal metastasis, cancer organoids were established from the ascites of...
ONECUT2-driven activation of ADAMTS14 boosts colorectal cancer stemness via Wnt pathway [0.03%]
ONECUT2通过Wnt信号激活ADAMTS14促进结直肠癌干细胞特性增强
Yicheng Jiang,Xingping Tan
Yicheng Jiang
The malignant progression of colorectal cancer (CRC) is closely related to cell stemness, but its regulatory mechanism has not been fully elucidated. This study found that ADAMTS14 was significantly highly expressed in CRC tissues and cell ...
The "dual personality" of LOXL3: a tumor accomplice and a new hope for immunotherapy [0.03%]
LOXL3的双重性格：肿瘤的帮凶与免疫治疗的新希望
Shuang Wu,Chao Huang
Shuang Wu
The lysyl oxidase family is a group of copper-containing amine oxidases involved in the remodeling of the extracellular matrix, and regulates cell signaling, metabolism, organ development, and immunity by modifying the cellular matrix. Amon...
Partial TEX14 peptides inhibit proliferation of cancer cells and have potential as anti-tumour agents [0.03%]
TEX14片段多肽具有抑制癌细胞增殖和抗肿瘤的潜力
Tokuko Iwamori,Yusuke Sakurai,Tasrin Sultana et al.
Tokuko Iwamori et al.
TEX14 is essential for the formation and maintenance of the intercellular bridge (ICB) which is one of the major cellular junctions required for spermatogenesis. Previously, TEX14 was shown to block germ cell abscission prior to cytokinesis...
Quick and robust method for the generation of human iPSC-derived choroid plexus organoids [0.03%]
快速而稳健的人类诱导多能干细胞来源脑室脉络丛类器官的生成方法
Rodi Kado Abdalkader,Takuya Fujita
Rodi Kado Abdalkader
The choroid plexus (ChP) is a key brain structure responsible for cerebrospinal fluid (CSF) production and forms a selective barrier that regulates brain homeostasis and immune surveillance. In vitro models of ChP are essential for studying...
WTAP-mediated m6A modification of PTPN1 contributes to ulcerative colitis pathogenesis through regulating colonic epithelial cell phenotypes [0.03%]
WTAP介导的PTPN1m6A修饰通过调节结肠上皮细胞表型参与溃疡性结肠炎发病机制
Yichi Zhang,Nijina Li,Dan Zhang et al.
Yichi Zhang et al.
Relapsing and remitting mucosal inflammation can potentially spread throughout the colon in cases of ulcerative colitis (UC). N6-methyladenosine (m6A) is the most prevalent epigenetic change in RNA, and it is essential to numerous biologica...
Screening and validation of autophagy-related mRNAs and lncRNAs in bone nonunion based on transcriptome sequencing analysis [0.03%]
基于转录组测序分析筛选并验证骨不连相关mRNA和lncRNA
Wei Xu,Qianliang Wang,Meng Li et al.
Wei Xu et al.
This study aims to screen for differentially expressed mRNAs (DEmRNAs) and lncRNAs (DELncRNAs) related to autophagy in bone nonunion through transcriptome sequencing, and explore their molecular mechanisms at the cellular level. In this stu...
Srpx2 exerts multifaceted cardio-protection in septic cardiomyopathy: PI3K/AKT-dependent attenuation of mitochondrial oxidative stress, apoptotic signaling, and inflammatory response [0.03%]
Septic心肌病中，Srx2通过PI3K / AKT依赖的途径减轻线粒体氧化应激，凋亡信号和炎症反应而产生多方面的保护作用
Yan Guo,Ying Liu,Mingkai Zhou et al.
Yan Guo et al.
Mitochondrial dysfunction is a key contributor to septic cardiomyopathy, driving myocardial inflammation and apoptosis. This study found that Sushi-repeat containing protein X-linked 2 (Srpx2) is associated with mitochondrial damage and is ...