Hsa_circ_0000437 promotes the progression of rheumatic valvular heart disease by activating the mitogen-activated protein kinase signaling pathways after sponging let-7f-5p and targeting RAS-like proto-oncogene B [0.03%]
Hsa_circ_0000437通过海绵吸附let-7f-5p并靶向RAS样原癌基因B激活丝裂原活化蛋白激酶信号通路促进风湿性瓣膜性心病的进展
Linwen Zhu,Ni Li,Huoshun Shi et al.
Linwen Zhu et al.
Circular RNAs (circRNAs) are involved in cardiovascular disease development and progression. We identified has_circ_0000437 from three pairs of clinical samples using a circRNA microarray and predicted the has_circ_0000437 sponge let-7f-5p ...
A novel function of STARD7: its tumor-promoting role involves the activation of NF-κB signaling pathway in ovarian cancer [0.03%]
STARD7的新功能：通过激活NF-κB信号通路促进卵巢癌的作用
Tian Tian,Xiaona Luan,Lingzhi Wang et al.
Tian Tian et al.
Ovarian cancer is one of the most lethal gynecologic malignancies contributing to cancer-related deaths among women. However, the mechanisms underlying its development remain poorly understood. This study aimed to investigate the role of ST...
Expansion characteristics of CD34+ cells derived from umbilical cord blood HS/PCs in single-parameter culture under serum-free static suspension condition [0.03%]
无血清悬浮培养体系中人胎盘造血干细胞/progenitor细胞CD34＋亚群的单指标扩增特征研究
Hezhi Chen,Liying Li,Weiting Guo et al.
Hezhi Chen et al.
Currently, the ex vivo expansion of hematopoietic stem/progenitor cells (HS/PCs) is one of the effective ways to address the shortage of HS/PCs for clinical transplantation. Therefore, the optimal in vitro expansion strategy for HS/PCs is a...
OTUB2 aggravates pathological cardiac hypertrophy through Rac1 activation [0.03%]
通过激活Rac1促进病理性心脏肥厚恶化
Junhui Xing,Lijin Lin,Yi Zhao et al.
Junhui Xing et al.
Pathological cardiac hypertrophy develops as a maladaptive response to sustained pressure overload, transitioning from compensatory adaptation to dysfunction. Understanding its molecular mechanisms is crucial for developing therapeutic stra...
Deciphering the relevance of dead box RNA helicases in gliomagenesis and autophagy [0.03%]
解码死盒RNA解旋酶在胶质瘤发生和自噬中的作用
Arpit Sharma,Naveen Soni,Megha Chaudhary et al.
Arpit Sharma et al.
Dead-box RNA helicases (DDXs) are a family of proteins with roles in RNA metabolism, regulating processes such as RNA splicing, translation, and ribosome assembly. Recently, their functions have expanded to include essential roles in autoph...
Establishment of immortalized ovarian stromal cell lines using Sendai virus vectors: a platform for studying tumor-stroma interactions and carcinogenesis [0.03%]
利用仙台病毒载体建立卵巢间质细胞永生化细胞系：研究肿瘤-间质相互作用和致癌的平台
Masayo Okawa,Hiroaki Komatsu,Yasuhiro Kazuki et al.
Masayo Okawa et al.
We aimed to generate immortalized stromal cell lines from the ovarian and fallopian tube tissues of a single patient using Sendai virus (SeV) vectors and identify candidate stromal genes involved in ovarian carcinogenesis. Tissues were coll...
RMND5A upregulation via IGF2BP3-mediated m6A RNA modification enhances malignant traits and immune evasion in laryngeal squamous cell carcinoma cells [0.03%]
通过IGF2BP3介导的m6A RNA修饰上调的RMND5A增强喉部鳞状细胞癌细胞的恶性表型和免疫逃逸能力
Shu Zhang,Xiaojun Li,Miao Zhang et al.
Shu Zhang et al.
N6-methyladenosine (m6A) is the most prevalent mRNA internal modification in eukaryotic mRNAs and is frequently associated with progression and immune response in human cancers. This study delves into the function of m6A reader insulin like...
CDC6 promotes the development and progression of clear cell renal cell carcinoma via upregulating RRM2 [0.03%]
CDC6通过上调RRM2促进透明细胞肾细胞癌的发生发展
Tianpeng Xie,Zanxuan Deng,Youping Ding et al.
Tianpeng Xie et al.
Clear cell renal cell carcinoma (ccRCC) is the most common type of renal cell carcinoma, and exploration of its molecular mechanism benefits for developing more effective molecular targeted drugs. CDC6 has been found to be highly expressed ...
Mitophagy is responsible to ionizing radiation but plays a very limited role in the radiosensitivity of adenocarcinoma cells [0.03%]
线粒体自噬对放射敏感性的影响作用微弱
Chen Yan,Kai Huang,Yong Xu et al.
Chen Yan et al.
Radioresistance of adenocarcinoma cells limits the efficiency of radiotherapy. In addition to the cell nucleus, ionizing radiation (IR) also induces damage to the mitochondria. Mitophagy, a selective degradation of impaired mitochondria via...
Establishment and characterization of a novel cell line ICH-BCPALL-3 from B cell precursor acute lymphoblastic leukemia with TCF3::HLF [0.03%]
TCF3::HLF阳性B系急性淋巴细胞白血病新型细胞系ICH-BCPALL-3的建立与鉴定
Keisuke Kato,Ioannis Panagopoulos,Ai Yoshimi et al.
Keisuke Kato et al.
In vitro models of acute leukemia are crucial for understanding its biology and developing effective treatments. The authors have established and characterized a novel cell line, ICH-BCPALL-3, which expresses the TCF3::HLF fusion from B cel...