Establishment of Coala: a novel 3D and 2D cancer cell line derived from colorectal cancer liver metastasis [0.03%]
Coala的建立：一种新型的源自结直肠癌肝转移细胞系
Sandra Mersakova,Juraj Marcinek,Dusan Brany et al.
Sandra Mersakova et al.
Metastatic colorectal cancer is one of the most critical causes of cancer-related dead in patients suffering this type of malignancy. As the liver metastases are found in almost 25-50% of all colorectal cancer patients, there is an urgent n...
Activated PLK1 promotes the migration and invasion of polyploid giant cancer cells with daughter cells via β-catenin/STAT3 signaling pathway [0.03%]
活化的PLK1通过β-catenin/STAT3信号通路促进多倍体巨癌细胞及其子细胞的迁移和侵袭
Xinyue Zhou,Yidi Ning,Xiaorui Wang et al.
Xinyue Zhou et al.
The abundance of polyploid giant cancer cells (PGCCs) is correlated with malignant tumor progression. PGCCs divide asymmetrically to generate daughter cells with high invasive and migratory capacities. The objective of this study was to inv...
Establishment and characterization of a novel patient-derived TP63-rearranged anaplastic large-cell lymphoma model PTCL-S1 [0.03%]
建立并表征一种新的患者衍生的TP63重排型间变性大细胞淋巴瘤模型PTCL-S1
Kelila Xin Ye Chai,Elizabeth Chun Yong Lee,Zhimei Li et al.
Kelila Xin Ye Chai et al.
Anaplastic large-cell lymphoma (ALCL) accounts for 15% of all peripheral T-cell lymphomas globally and can be further divided into subcategories, of which patients with ALK-negative ALCL have dismal prognosis and overall survival. We establ...
Editorial Expression of Concern: Human placental mesenchymal stromal cell therapy restores the cytokine efflux and insulin signaling in the skeletal muscle of obesity-induced type 2 diabetes rat model [0.03%]
关于胎盘间充质干细胞治疗恢复肥胖诱导的2型糖尿病大鼠骨骼肌细胞因子流出和胰岛素信号表达的更正及声明
Nagasuryaprasad Kotikalapudi,Samuel Joshua Pragasam Sampath,Sukesh Narayan Sinha et al.
Nagasuryaprasad Kotikalapudi et al.
Correction: IL-32/NFκB/miR-205 loop sustains the high expression of IL-32 and enhances the motility of cervical cancer cells [0.03%]
订正：IL-32/NFκB/miR-205环状调控维持高表达并增强宫颈癌细胞迁移能力
Jianbing Liu,Kai Yang,Xiaoyu Lin et al.
Jianbing Liu et al.
Published Erratum
Human cell. 2025 Jul 22;38(5):133. DOI:10.1007/s13577-025-01260-5 2025
Naoya Nakahashi,Makoto Emori,Yasutaka Murahashi et al.
Naoya Nakahashi et al.
Pleomorphic rhabdomyosarcoma (pRMS) is a rare and highly malignant mesenchymal tumor. Complete resection is the only curative treatment available, owing to the limited efficacy of chemotherapy and radiotherapy. Therefore, developing novel t...
Blocking secretion of exosomes by GW4869 dampens CD8+ T cell exhaustion and prostate cancer progression [0.03%]
通过GW4869阻断外泌体分泌可抑制CD8+t细胞衰竭和前列腺癌进展
Jing Liu,Hongyan Guo,Shiqi Liu et al.
Jing Liu et al.
Functional exhaustion of T lymphocytes is considered an important factor in the failure of tumor treatment. Accumulating evidence has shown that tumor cells cultivate their immune microenvironment through secreting exosomes. However, the me...
Metformin promotes osteogenic differentiation of human periodontal ligament stem cells via KLF2-mediated activation of miR-181a-5p under lipopolysaccharide stimulation [0.03%]
二甲双胍通过KLF2介导的miR-181a-5p激活促进脂多糖刺激下的人牙周膜干细胞成骨分化
Xu Zhang,Wen Hu,Hua Hua
Xu Zhang
Periodontal ligament stem cells (PDLSCs) constitute a promising source for successful periodontal regeneration. This study aims to explore roles of metformin, krüppel-like factor 2 (KLF2), and miR-181a-5p in mediating osteogenic differenti...
Activation of the circAGFG1/miR-195-5p/PD-L1 axis induces lung injury in sepsis [0.03%]
circAGFG1/miR-195-5p/PD-L1信号轴活化诱发脓毒症肺损伤
Yang Bi,Rui Ding,Xinyan Liu et al.
Yang Bi et al.
Severe sepsis can escalate to acute lung injury (ALI), a critical condition with limited treatment options. Emerging research highlights the role of non-coding RNAs, including microRNAs (miRNAs) and circular RNAs (circRNAs), in regulating e...
Establishment and characterization of two novel patient-derived cell lines from giant cell tumor of bone: NCC-GCTB11-C1 and NCC-GCTB12-C1 [0.03%]
由骨巨细胞瘤患者衍生的两个新型细胞系NCC-GCTB11-C1和NCC-GCTB12-C1的建立与鉴定
Yuki Adachi,Takuya Ono,Rei Noguchi et al.
Yuki Adachi et al.
Giant cell tumor of bone (GCTB) is locally aggressive and rarely metastasizing mesenchymal tumor, molecularly characterized by the presence of H3-3A mutation. The management of GCTB is problematic because of local recurrence after curative ...