Potential of potentiometric biosensors for the study of ion influx and efflux via gasdermin pores in plasma membrane in pyroptosis: a hypothesis [0.03%]
关于潜在的电势生物传感器研究吡毒素中通过气导敏蛋白孔道进入和流出离子的可能性：一种假说
Caglar Berkel,Oguz Özbek,Onur Cem Altunoluk
Caglar Berkel
Dysfunctional variants of ABCG2 create strong individual and population risks for progression of hyperuricemia: the potential for implementation of genome-personalized nursing [0.03%]
ABCG2功能异常型通过促进高尿酸血症进展从而在个体和人群层面产生较强的发病风险：实施基因组个性化护理的潜力分析
Akiyoshi Nakayama,Kimiko Hayano,Miki Ueno et al.
Akiyoshi Nakayama et al.
Gout, a common disease, develops after prolonged hyperuricemia with elevated serum uric acid (SUA) levels. Sex, overweight/obesity, heavy drinking, and aging all increase risk. Common dysfunctional variants (polymorphisms) in the ABCG2/BCRP...
HSPA8 promotes the progression of gastric cancer by activating the canonical Wnt pathway and glycolysis [0.03%]
HSPA8通过激活经典Wnt信号通路和糖酵解促进胃癌进展
Xiaoyi Shi,Peng Ge,Yalan Luo et al.
Xiaoyi Shi et al.
HSPA8, a crucial molecular chaperone, has been implicated in the promotion of cancer across various malignancies. The clinical significance of HSPA8 in gastric cancer (GC) and its molecular contribution to tumour progression are unknown. Se...
Neuroprotective activity of thiolutin in epileptic mice: the inhibition of NLRP3 inflammasome [0.03%]
氯硫锌素通过抑制NLRP3炎性小体对癫痫小鼠的神经保护作用研究
Jiadong Sun,Caili Fan,Xiaoyu Chen et al.
Jiadong Sun et al.
Neuroinflammation is a key mechanism in epileptogenesis. Thiolutin (THL), an inhibitor of NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome, targets a central driver of the neuroinflammatory cascade. However, its role in...
Exosomal miR-145-5p impairs neoadjuvant chemotherapy by suppressing TFRC-mediated macrophage iron uptake and driving M2 polarization in esophageal cancer [0.03%]
外泌体miR-145-5p通过抑制TFRC介导的巨噬细胞铁摄取并驱动M2极化从而损害食管癌新辅助化疗
Jianfeng Xu,Deng Lei,Peng Xu et al.
Jianfeng Xu et al.
Esophageal cancer (EC) remains a highly aggressive malignancy with limited therapeutic success, partly due to heterogeneous responses to neoadjuvant chemotherapy (NAC). Tumor-derived exosomes and tumor-associated macrophages play critical r...
Fumio Kasai,Hiroaki Kataoka
Fumio Kasai
Human cellular models used as materials in 183 articles published in *Human Cell* during 2025 comprise a total of 313 samples (Table 1, Tables S1, S2). This highlights current trends in research involving human cells and raises concerns abo...
Interplay between TGF-β signaling and long non-coding RNAs in digestive system cancers: mechanisms and biological implications [0.03%]
转化生长因子-β信号与长链非编码RNA在消化系统肿瘤中的相互作用：机制及生物学意义
Penghui Li,Di Huang,Xinyu Gu
Penghui Li
The interaction between the transforming growth factor beta (TGFβ) signaling pathway and long non-coding RNAs (lncRNAs) has been known to contribute to the progression and metastasis of digestive system cancers. Dysregulated expression of ...
Radiotherapy or chemoradiotherapy might sensitize cervical cancer cells to plasma membrane rupture during necroptosis by upregulating the expression of SIGLEC12, a recently identified membrane-rupturing protein [0.03%]
放射治疗或放化疗可通过上调近期鉴定的促细胞膜破裂蛋白SIGLEC12的表达，增强宫颈癌细胞的细胞坏死性凋亡导致的细胞膜破裂效应
Caglar Berkel
Caglar Berkel
Antitumoral effect of Nitraria retusa bioactive compounds on two glioblastoma cell lines [0.03%]
硝化植物鲁萨草活性化合物对两种胶质母细胞瘤细胞系的抗肿瘤作用
Jihed Boubaker,Aida Lahmar,Abir Salek et al.
Jihed Boubaker et al.
The objective of this research was to investigate the effects of proven antioxidant compounds identified in Nitraria retusa leaf extracts (Nr-extracts) on glioblastoma (GBM) cells. The antioxidant capacity was evaluated in nonenzymatic, enz...
Generation and characterization of early stage oral cancer cell line of buccal mucosa of Indian origin [0.03%]
印度起源的颊粘膜早期口腔癌细胞系的建立和鉴定
Akhila George,Sudhir Nair,Kumar Prabhash et al.
Akhila George et al.
Being topmost cancer in India, oral cancer management warrants discovery of novel biomarkers, treatment strategies, and targets to help with early diagnosis, treatment, and recovery. To have a continuous supply of cells, the study was aimed...