The cell-surface serine protease prostasin is lost during cervical squamous cell carcinogenesis [0.03%]
鳞状细胞宫颈癌变过程中细胞表面丝氨酸酶prostasin的丢失
Joseph G Lundgren,Michael G Flynn,Karin List
Joseph G Lundgren
The glycosylphosphatidylinositol (GPI)-anchored serine protease prostasin has been reported to have increased expression with tumor-promoting properties in some cancer types, while expression is lost and prostasin displays tumor-suppressing...
The expression of PD-1 ligands in the immune microenvironment was altered in TTF-1-negative lung adenocarcinoma [0.03%]
TTF-1阴性肺腺癌免疫微环境中的PD-1配体表达改变
Hiroyuki Yamada,Hiromu Yano,Eri Matsubara et al.
Hiroyuki Yamada et al.
Thyroid transcription factor-1 (TTF-1) is a lineage-specific marker for lung adenocarcinoma (LUAD), whereas the relatively minor subset of TTF-1-negative LUADs shows a poor prognosis and a limited response to therapy. However, its relations...
Exosomal FGD5-AS1 promotes proliferation of lung cancer cells under hypoxia by inhibiting miR-1179 and activating P-cadherin [0.03%]
低氧条件下FDG5_AS1通过抑制miR_1179激活P_cadherin促进肺癌细胞增殖的作用机制研究：基于外泌体的长链非编码RNA分子的研究
Bilan Yang,Zhongkun Tian,Zhiqiang Luo et al.
Bilan Yang et al.
Lung adenocarcinoma (LUAD) continues to be a major contributor to cancer-related deaths due to its aggressive nature and resistance to current therapies, highlighting the need for novel molecular insights and therapeutic targets. This study...
Establishment and characterization of a new Chinese extrahepatic cholangiocarcinoma cell line, EBC-X1 [0.03%]
建立并表征新的中国肝外胆管癌细胞系EBC-X1
Yuanhui Su,Huan Tang,Xin Miao et al.
Yuanhui Su et al.
Cholangiocarcinoma (CCA) is a highly heterogeneous primary malignant tumor of the biliary tract. Intrahepatic and extrahepatic cholangiocytes originate from different sources, resulting in significant clinical, epidemiological, molecular, a...
Unveiling the vital role of OGG1 in inflammation, vascular endothelial damage, and cell death in obstetric and gynecological diseases [0.03%]
OGG1在生殖系统炎症、血管内皮损伤及细胞死亡中的重要作用及其机制研究
Yang Li,Wenying Zhang,Bo Wang et al.
Yang Li et al.
The DNA repair enzyme 8-oxoguanine DNA glycosylase-1 (OGG1) plays a crucial role in the initiation of DNA base excision repair pathway by recognizing and excising the oxidative base lesions including 7,8-dihydro-8-oxoguanine (8-oxoG). Beyon...
ATG5-mediated cGAS-STING-NLRP3 axis alleviates symptoms of knee osteoarthritis [0.03%]
ATG5介导的cGAS-STING-NLRP3轴缓解膝骨关节炎症状
Hao Wu,Jinhong Yan,Qian Zhang et al.
Hao Wu et al.
Knee osteoarthritis (KOA) is a degenerative joint disorder characterized by articular cartilage degeneration and synovial inflammation. Dysfunction mediated by autophagy-related protein 5 (ATG5) represents a key driver of KOA pathogenesis, ...
Bone marrow mesenchymal stem cell-derived exosomal METTL14 promotes the osteogenic differentiation of MC3T3-E1 cells by regulating BMP2 in bone fracture recovery [0.03%]
骨髓间充质干细胞源性METTL14外泌体通过调控BMP2促进骨折修复中MC3T3-E1细胞成骨分化
Min Liu,Zhenye Guo,Xiaoyan Shi et al.
Min Liu et al.
Bone fracture healing is a complex physiologic process that aims at restoring the damaged bone to its pre-injury state and cellular composition. Exosomes secreted by bone marrow mesenchymal stem cells (BMSCs) are emerging as a promising str...
Robo4 inhibits neovascularization in oxygen-induced retinopathy by regulating ARF6 and VEGF [0.03%]
ROBO4通过调节ARF6和VEGF抑制氧诱导性视网膜病变新生血管形成
Yujun Liao,Chunhong Yu,Weiwei Xiong et al.
Yujun Liao et al.
Retinopathy of prematurity (ROP) is an abnormal proliferative disease of retinal blood vessels. This study investigates the role of Robo4 in angiogenesis and its molecular mechanisms in the Oxygen-Induced Retinopathy (OIR) model and a hypox...
Leucyl-tRNA synthetase promotes malignant progression in diffuse large B-cell lymphoma by regulating glycolysis via the LRPPRC/HIF-1α/HK2 axis [0.03%]
亮氨酰-tRNA合成酶通过LRPPRC/HIF-1α/HK2轴调节糖酵解促进弥漫性大B细胞淋巴瘤恶性进展
Weiming Zhang,Nasha Yu,Xiangxiang Song et al.
Weiming Zhang et al.
Diffuse large B-cell lymphoma (DLBCL) is a malignant tumor and research on its therapeutic targets has received increasing attention. It has been reported that Leucyl-tRNA synthetase (LARS) contributes to the growth and migration of non-Hod...
Palmatine inhibits colorectal cancer proliferation and metastasis by regulating miR-363-3p/AURKA axis [0.03%]
棕亭胺通过调控miR-363-3p/AURKA轴抑制结直肠癌的增殖和转移
Changxia Mao,Xue Chai,Huan He et al.
Changxia Mao et al.
Colorectal cancer, a prevalent digestive system malignancy, is characterized by a high incidence, low early detection rate, limited surgical resection opportunities, and high mortality. Palmatine (PAL), an active ingredient primarily found ...