Herbacetin alleviates acute doxorubicin cardiotoxicity via regulating the ERK1/2-FOXO3a signaling pathway [0.03%]
黄芩素通过调节ERK1/2-FOXO3a信号通路缓解阿霉素急性心毒性
Sijia Bian,Xinran Li,Peiyan Zhu et al.
Sijia Bian et al.
Doxorubicin (DOX) is a commonly prescribed chemotherapeutic regimen, but its practice is challenged by cardiotoxicity risks. Herbacetin (HBT), a bioactive flavonoid compound, has demonstrated anti-oxidative, anti-inflammation, and anti-tumo...
The sialyltransferase ST3GAL1 mediates MUCL1 sialylation to exacerbate breast cancer progression [0.03%]
ST3GAL1唾液酸转移酶介导的MUCL1唾液酸化可促进乳腺癌进展
Can Cui,Jing Feng,Boyu Shang et al.
Can Cui et al.
Breast cancer is highly heterogeneous and involves complex molecular mechanisms, posing significant therapeutic challenges. Glycosylation modifications, particularly sialylation, play a critical role in tumor progression. The sialyltransfer...
DKK1 exacerbates dental pulp inflammation: insights from RNA-sequencing analysis [0.03%]
DKK1加剧牙髓炎症：来自RNA测序分析的见解
Qiting Liang,Jingyi Ding,Jiayan Xie et al.
Qiting Liang et al.
Dickkopf-related protein 1 (DKK1) has been implicated in several inflammatory diseases; however, its role in pulpitis remains poorly understood. This study aimed to investigate the role and underlying molecular mechanisms of DKK1 on pulpiti...
MKRN2 enhances hepatocellular carcinoma proliferation through the p38 MAPK pathway [0.03%]
MKRN2通过p38MAPK途径促进肝癌细胞增殖
Xiaojing Chen,Zihan Yan,Xinrui Du et al.
Xiaojing Chen et al.
Elucidating the molecular mechanisms underlying hepatocellular carcinoma (HCC) pathogenesis is crucial for the development of targeted therapies. Makorin-2 (MKRN2), a member of the makorin RING zinc finger protein family, acts as an E3 ubiq...
5-Azacytidine induces sensory hair cell marker expression in human inner ear cells in vitro [0.03%]
5-氮杂胞苷诱导人内耳细胞系分化的听觉毛细胞标志物的表达
Meng Deng,Zhengqing Hu
Meng Deng
Adult human inner ear hair cells have extremely limited regenerative ability, and the inaccessibility of human inner ear tissue makes studying regeneration challenging. In this study, we examined whether 5-azacytidine (5-aza) could induce h...
Establishment and characterization of a novel sinonasal adenosquamous carcinoma cell line, TC717, with a high tumor mutational burden [0.03%]
Ryosuke Kuga,Takeo Yamamoto,Takeshi Iwasaki et al.
Ryosuke Kuga et al.
We established and characterized a novel human sinonasal adenosquamous carcinoma (ASC) cell line, TC717, derived from a 64-year-old, never-smoking woman. The patient received neoadjuvant chemotherapy followed by total maxillectomy but succu...
Case Reports
Human cell. 2026 Feb 24;39(3):45. DOI:10.1007/s13577-026-01360-w 2026
The role of macrophages in peritoneal dialysis-associated peritoneal fibrosis [0.03%]
腹膜透析相关性腹膜纤维化中巨噬细胞的作用
Jianqiang Shu,Zhikang Sun,Wenwen Zhao et al.
Jianqiang Shu et al.
The peritoneum is the largest and most complex serous membrane in the body belonging to the category of semi-permeable membrane. Peritoneal dialysis, which is based on this principle, has become a primary treatment for patients with end-sta...
SIRT1 reduced DDX5 neddylation to attenuate myocardial ischemia/reperfusion injury [0.03%]
SIRT1通过减少DDX5泛素化修饰减轻心肌缺血再灌注损伤
Yan Liang,Gongcheng Huang,Xiaohua Zhu et al.
Yan Liang et al.
Background: SIRT1 exhibited a protective role in myocardial ischemia/reperfusion injury (MI/RI), but the related mechanisms remained unclear. In this study, the regulation of SIRT1 on neddylation modification in MI/RI was...
Conditioned medium from human adipose-derived mesenchymal stromal cells can modulate cell migration and morphology of keratinocytes in vitro [0.03%]
人源脂肪基质干细胞培养上清液可调节体外角质形成细胞的迁移和形态变化
Cristiano Rodrigues,Thaís Casagrande Paim,Carla Zanatelli et al.
Cristiano Rodrigues et al.
The regenerative ability of the skin is orchestrated by different types of cells, including mesenchymal stromal cells (MSCs). Their role in wound healing is being widely studied due to their capacity to produce a secretome able to modulate ...
The interplay between circadian rhythm components and apoptosis in health and disease [0.03%]
生理节律与凋亡在健康和疾病中的相互作用
Mohammad Rafi Khezri,Somayeh Mohammadi Panah,Morteza Ghasemnejad-Berenji et al.
Mohammad Rafi Khezri et al.
In humans, circadian rhythm regulates the expression of numerous protein-coding genes across nearly all cell types, playing a central role in maintaining health. However, circadian rhythm components interact with a wide variety of intracell...