Apigenin inhibits endothelial-to-mesenchymal transition of coronary artery endothelial cells and myocardial fibrosis by regulating ribosome biogenesis through GTPBP4 modulation [0.03%]
染色质重塑蛋白GTPBP4调控核糖体生成，黄酮类化合物Apigenin通过该途径抑制冠状动脉内皮细胞上皮间质转化及心肌纤维化
Xiaoyong Hu,Zhaoying Yang,Rui Tang et al.
Xiaoyong Hu et al.
Myocardial fibrosis is a complex pathological process that often leads to myocardial dysfunction, heart failure, and ultimately, death. A critical contributor to the development of cardiac fibrosis is the endothelial-to-mesenchymal transiti...
Correction: Long non-coding RNA DUXAP10 exerts oncogenic properties in osteosarcoma by recruiting HuR to enhance SOX18 mRNA stability [0.03%]
长非编码RNA DUXAP10通过招募HuR增强SOX18 mRNA稳定性在骨肉瘤中发挥致癌作用的修正观点
Guantong Wang,Qian Zhang,Qinjue Wang et al.
Guantong Wang et al.
Published Erratum
Human cell. 2025 Sep 12;38(6):156. DOI:10.1007/s13577-025-01281-0 2025
SIRT1 as a potential target for age-related eye diseases: mechanisms and therapeutic strategies [0.03%]
SIRT1可能是年龄相关性眼病的治疗靶点：机制和治疗策略
Huirui Liu,Yuting Ouyang,Hongyan Ge
Huirui Liu
Age-related eye diseases (AREDs) are the leading cause of visual impairment in the elderly, affecting the structure of the anterior and posterior segments of the eye, significantly reducing the quality of life of patients, and even leading ...
USF1-induced RPS6KB2 activation influences aggressive phenotype in B-cell non-Hodgkin lymphoma [0.03%]
USF1通过激活RPS6KB2影响B细胞非霍奇金淋巴瘤的侵袭表型
Zhaoyu Liu,Xiang Song,Zhuang Liu et al.
Zhaoyu Liu et al.
B-cell non-Hodgkin lymphoma (B-NHL) is a diverse group of aggressive lymphoid malignancies characterized by its molecular complexity. This study investigated the role of the upstream stimulatory factor 1 (USF1)-ribosomal protein S6 kinase B...
FTO inhibited miR-487a-3p biosynthesis via N6-methyladenosine-dependent pathway to promote WNT5A-mediated osteogenic differentiation of adipose-derived stem cells [0.03%]
FTO通过N6-甲基腺苷依赖性通路抑制miR-487a-3p生物合成以促进WNT5A介导的脂肪源性干细胞成骨分化
Yong Li,Yang Yue,Chaoqun Cen et al.
Yong Li et al.
miR-487a-3p shows the potential of modulating adipose-derived stem cells (ADSCs) differentiation. This study aimed to investigate the mechanism of miR-487a-3p on the osteogenic differentiation of ADSCs. In this work, ADSCs were induced to d...
100% Fish oil-based lipid emulsion inhibits hepatic stellate cell activation via suppression of the TGF-β1 autocrine signaling [0.03%]
100％鱼油基脂质乳剂通过抑制TGF-β1自分泌信号抑制肝星状细胞活化
Ryo Watanabe,Mayako Morii,Kenki Yamagata et al.
Ryo Watanabe et al.
Intestinal failure-associated liver disease (IFALD) is a life-threatening complication of short bowel syndrome (SBS), characterized by cholestasis, hepatic steatosis, and hepatic fibrosis. Fish oil-based lipid emulsion (FO) has been demonst...
Keywan Mortezaee
Keywan Mortezaee
Regulatory T cell (Treg) immunome profile and targets in antiprogrammed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) is a subject of extensive research, but there are still complexities in the area due to the nature of tumor m...
Nicotinamide N-methyltransferase enhances paclitaxel resistance in ovarian clear cell carcinoma [0.03%]
尼可酸-N-甲基转移酶通过表观遗传学调控增强卵巢透明细胞癌对紫杉醇的耐药性
Ryoko Kikuchi-Koike,Masaru Sakamoto,Yuko Sasajima et al.
Ryoko Kikuchi-Koike et al.
Nicotinamide N-methyltransferase (NNMT) is an S-adenosyl-l-methionine (SAM)-dependent cytosolic enzyme, and a growing body of evidence suggest that it plays an essential role in cancer progression. Recently, NNMT has a role in methylation m...
Simulating tumor complexity: 3D pancreatic tumor spheroid model for improved drug screening [0.03%]
模拟肿瘤复杂性：改进药物筛选的三维胰腺肿瘤类器官模型
Bano Subia,Ankit Patel,Simran Nathwani et al.
Bano Subia et al.
Most drug discovery studies use 2D cell cultures and animal models for screening new chemical entities (NCEs), which often leads to suboptimal results due to genetic variations, species differences, or lack of most physiological preclinical...
Collagen alpha-5(IV) chain activation by nuclear factor 1/C promotes nasopharyngeal carcinoma progression [0.03%]
核因子1/C促进胶原α-5（IV）链活化从而促进鼻咽癌进展
Ying Cao,Peibei Wang,Peng Li et al.
Ying Cao et al.
The expression of collagen receptors by cancer cells serves a vital function in the regulation of cell behavior. These receptors are capable of sensing the signals generated by alterations in the collagen state, thereby contributing to the ...