Eucommia ulmoides (Duzhong) extract alleviates cerebral stroke by inhibiting ferroptosis-related gene DNA Damage-Inducible Transcript 4 (DDIT4) expression [0.03%]
杜仲叶提取物通过抑制铁死亡相关基因DNA损伤诱导转录4（DDIT4）表达缓解脑卒中
Xin Qi,Mengyuan Deng,Minhong Li et al.
Xin Qi et al.
Cerebral stroke is an acute cerebrovascular disease, which is characterized by significant morbidity, death, and disability rate. Ischemic stroke is more than hemorrhagic stroke and accounts for 60-70% of all strokes. The present study expl...
Hofbauer cell alterations and potential role in the pathophysiology of HELLP syndrome [0.03%]
hofbauer细胞改变与HELLP综合征发病机制的潜在作用
Ayano Ezaki,Akihito Sagara,Yoshihiro Komohara et al.
Ayano Ezaki et al.
HELLP syndrome, a severe pregnancy complication characterized by hemolysis, elevated liver enzymes, and low platelet count, is a subtype of preeclampsia (PE). However, its rapid onset and unique clinical features suggest distinct underlying...
Exportin-1 and epigenetic modifications interaction: more than nuclear transport [0.03%]
出口蛋白1与表观遗传修饰的相互作用：不仅仅是核运输
Leonidas Benetatos,Eleftheria Hatzimichael,Eleni Kapsali
Leonidas Benetatos
Exportin-1 (XPO1) is fundamental in the regulation of nuclear-to-cytoplasm transportation. XPO1 has the ability to transport hundreds of proteins and several different types of mRNAs responsible for proper cellular biology. Deregulation of ...
Generation of human induced pluripotent stem cell lines derived from Wolf-Hirschhorn syndrome patients with chromosomal 4p deletion [0.03%]
由4号染色体短臂缺失的Wolf-Hirschhorn综合征患者诱导的多能干细胞系的建立
Tomoya Shimizu,Miho Takami,Mami Matsuo-Takasaki et al.
Tomoya Shimizu et al.
Wolf-Hirschhorn syndrome (WHS) is a devastating congenital disease caused by deletions on the short arm of chromosome 4 (4p), for which no curative treatments currently exist. To facilitate the development of therapeutic strategies, the dev...
ODC1 loss upon KLF6 upregulation promotes macrophage pyroptosis and acute kidney injury in sepsis [0.03%]
KLF6上调介导的ODC1丢失促进脓毒症中的巨噬细胞焦亡及急性肾损伤
Jiansheng Ding,Shijie Zhang,Xiangxian Zhang
Jiansheng Ding
The excessive inflammatory cascade in sepsis represents a major cause of multiorgan injuries, including sepsis-associated acute kidney injury (SAKI). Following the bioinformatics prediction, this study aims to investigate the role of ornith...
tRNA-derived small RNAs: emerging regulators of ferroptosis in human diseases [0.03%]
tRNA衍生的small RNA：人类疾病中铁死亡的新兴调节因子
Jiqing Zhang,Mu Liu,Zhongjun Li
Jiqing Zhang
tRNA-derived small RNAs (tsRNAs) are functional non-coding RNAs that play crucial roles in transcriptional, translational, and epigenetic regulation. Ferroptosis is an iron-dependent form of programmed cell death driven by lipid peroxidatio...
A stem cell-based toolkit to model Angelman syndrome caused by paternal uniparental disomy of chromosome 15 [0.03%]
基于干细胞的工具包用于建模由于15号染色体父系单亲二倍体导致的天使人综合症
Francisca Cazaux Mateus,João Camões Dos Santos,Maria Arez et al.
Francisca Cazaux Mateus et al.
Angelman syndrome is a rare neurodevelopmental disorder caused by the loss of function of the maternally inherited UBE3A gene within the chr15q11-q13 region. This gene is subjected to a tissue-specific form of genomic imprinting leading to ...
Samanmitha Srinivasa,Shuchi Odiyanda Charmanna,Rachana Rajesh Nayak et al.
Samanmitha Srinivasa et al.
The liver is the largest internal organ. Several critical functions are attributed to the liver which include metabolism, synthesis of serum proteins, excretion, detoxification, and various physiological processes essential for maintaining ...
Establishment of KGAS, a cell line derived from gastric-type adenocarcinoma of the uterine cervix [0.03%]
宫颈胃型腺癌细胞系KGAS的建立
Hiroaki Yamada,Akira Yokoi,Eri Asano-Inami et al.
Hiroaki Yamada et al.
Gastric-type adenocarcinoma (GAS) of the uterine cervix is a rare and aggressive subtype of cervical adenocarcinoma characterized by intrinsic resistance to chemotherapy and poor clinical outcomes due to the lack of effective treatment opti...
The SWI/SNF chromatin remodeling complex subunit BAF53B as an immunohistochemical marker for neuroendocrine neoplasms [0.03%]
BAF53B作为神经内分泌肿瘤免疫组化标志物的研究及其在肺癌中的临床应用研究
Kouhei Sakurai,Mako Ochiai,Kanata Kojima et al.
Kouhei Sakurai et al.
The Switch/Sucrose Nonfermentable (SWI/SNF) complexes are chromatin remodeling factors that consist of multiple protein subunits. Each subunit plays a distinct role in gene regulation and is aberrantly expressed in tumors, such as neuroendo...