Induction of activating transcription factor 3 (ATF3) in the cerebral cortex of a mouse model of blast-induced traumatic brain injury [0.03%]
炸弹爆震诱导创伤性脑损伤小鼠大脑皮层激活转录因子3（ATF3）的表达
Arumu Endo,Yasushi Satoh,Minori Koga et al.
Arumu Endo et al.
Traumatic brain injury (TBI) is a leading cause of long-term disabilities and mortality worldwide. Blast-induced TBI (bTBI) is the injury most commonly sustained by military personnel, but the pathomechanisms are largely unknown. Recently, ...
An overview of the developments in 3D cancer cell models, assay techniques, and imaging modalities [0.03%]
三维癌症细胞模型、试验技术和成像方式的发展概况
Nicola H Wheeler,Kayode A Dada,Carrie A Minnaar
Nicola H Wheeler
Cancer biology is a constantly evolving field of study due to the dynamic and complex nature of biological systems. The unique role of in vitro assays in cell biology has led to numerous transformations in our understanding of the functiona...
Ubiquitously expressed prefoldin-like chaperone (UXT) regulates putrescine metabolism and promotes colorectal cancer progression [0.03%]
泛表达伴侣蛋白辅酶（UXT）调控腐胺代谢并促进结直肠癌进展
Ming Chen,Shisi Huang,Lu Gong et al.
Ming Chen et al.
Colorectal cancer (CRC) is a prevalent and increasingly common malignancy that poses significant threats to patient survival and quality of life. This study investigates the role of ubiquitously expressed prefoldin-like chaperone (UXT) in r...
Advancing diagnostic biomarkers in Alzheimer's disease: interdisciplinary innovations and technological frontiers [0.03%]
阿尔茨海默病诊断生物标志物研究进展：跨学科创新与技术前沿
Faheem Patwekar,Mohsina Patwekar,Lee Seong Wei et al.
Faheem Patwekar et al.
Developing diagnostic biomarkers for Alzheimer's disease (AD) is at the cutting edge of interdisciplinary research and technical advancement. This comprehensive analysis investigates potential options for improving diagnostic accuracy and e...
CBC3T-3: a novel patient-derived cisplatin-resistant distal cholangiocarcinoma cell line harboring multiple TP53 missense mutations [0.03%]
一种新的含有多处TP53错义突变的吉西他滨顺铂耐药型壶腹癌细胞系CBC3T-3
Jiahui Xi,Mingzhen Bai,Ruyang Zhong et al.
Jiahui Xi et al.
Distal cholangiocarcinoma (dCCA) is a malignant tumor characterized by a challenging diagnosis, high invasiveness, and extremely poor prognosis. Research on dCCA is limited by the scarcity of reliable patient-derived preclinical tumor model...
Arginine deprivation induces ROS dependent autophagic cell death in human acute myeloid leukemia cells [0.03%]
精氨酸剥夺通过ROS诱导自噬性细胞死亡在急性髓系白血病中发挥重要作用
Fatima Taki,Mirna Farhat,Oula El-Atat et al.
Fatima Taki et al.
In this study, we assess the activation of autophagy and its impact on cytotoxicity following [HuArgI (Co)-PEG5000]-induced arginine deprivation in AML cells. We have previously shown that arginine deprivation is selectively cytotoxic to AM...
Rolled amniotic membrane for practical vascular graft development: a scoping review [0.03%]
卷绕的胎盘膜在血管移植物开发中的应用：系统综述
Ahmad Hafiz Murtadha,Nur Najmi Mohamad Anuar,Mohamad Fikeri Ishak et al.
Ahmad Hafiz Murtadha et al.
Small-diameter vascular grafts remain a clinical challenge due to thrombosis, stenosis, and poor long-term patency of synthetic substitutes. Decellularised human amniotic membrane (dHAM), derived from placental tissue, offers a promising al...
Unveiling TNFRSF19: a novel tumor suppressor targeting endoplasmic reticulum stress and LGR5/Wnt/β-catenin in cervical cancer [0.03%]
TNFRSF19去盖：宫颈癌内质网应激和LGR5/Wnt/beta; catenin的新型抑癌靶点
Xing Wei,Lili Su,Ran Chen et al.
Xing Wei et al.
TNF Receptor Superfamily Member 19 (TNFRSF19) has been implicated in the advancement of several types of cancer. However, its function and mechanism in cervical cancer (CC) remain unclear. Additionally, while ER stress is proposed as a ther...
Femtosecond label-free imaging evaluates the metabolism of mesenchymal stromal cells [0.03%]
飞秒无标记追踪成像评估间质干细胞代谢
Jiawei Liu,Yang Liu,Benhan Xiong et al.
Jiawei Liu et al.
Mesenchymal stromal cells (MSCs) hold significant promise in regenerative medicine, yet their clinical application is hindered by challenges such as cellular heterogeneity and quality control. This study aims to develop a rapid, noninvasive...
Establishment and characterization of NCC-GCTB16-C1: novel patient-derived cell line of giant cell tumor of bone [0.03%]
NCC-GCTB16-C1的建立及特性分析：骨巨细胞瘤患者来源的新细胞系
Kenta Kono,Yomogi Shiota,Julia Osaki et al.
Kenta Kono et al.
Giant cell tumor of bone (GCTB) is a locally aggressive osteolytic bone tumor characterized by recurrent mutation in the H3-3A gene. Although surgical resection remains the mainstay of treatment, a considerable proportion of patients experi...