Histone H4K5 deacetylation by enhanced HDAC1 expression drives endothelial inflammation in diabetes through repression of the KLF2-eNOS axis [0.03%]
糖尿病中增强的组蛋白脱乙酰酶1通过抑制KLF2-eNOS轴诱导内皮细胞炎症及H4K5去乙酰化作用的研究
Srinjoy Chakraborty,Vivek Akhouri,Yash Tushar Katakia et al.
Srinjoy Chakraborty et al.
Endothelial dysfunction is a hallmark of diabetes, primarily driven by fluctuating blood glucose levels that contribute to vascular complications. Epigenetic regulation through histone modifications plays a crucial role in mediating such pa...
miR-16-2-3p enhances glucocorticoid sensitivity in ulcerative colitis by targeting CREB1 and NF-κB1 [0.03%]
miR-16-2-3p通过靶向CREB1和NF-κB1提高糖皮质激素在溃疡性结肠炎中的敏感性
Tianfeng Yang,Juan Luo,Junrui Tang et al.
Tianfeng Yang et al.
In this study, we systematically investigated the role of miR-16-2-3p, a microRNA passenger strand derived from the MIR16-2 hairpin, in glucocorticoid resistance (GCR) and its underlying regulatory mechanisms. The results showed that miR-16...
Gata1-mediated Hras transcription stimulates blood-brain barrier injury in ischemic stroke through activation of the ERK pathway [0.03%]
GATA1介导的Hras转录通过激活ERK通路促进缺血性卒中后的血脑屏障损伤
Kelong Chen,Ling Chen,Huijing Sun et al.
Kelong Chen et al.
Disruption of the blood-brain barrier (BBB) is an essential pathological outcome of ischemic stroke (IS). This study aimed to prove that Gata1 upregulates Hras and promotes ERK signaling, leading to BBB damage in IS. Middle cerebral artery ...
NOTCH3 signal activation by its extracellular domain accumulation in an iPSC line newly established from a CADASIL patient [0.03%]
CADASIL患者新建立的诱导多能干细胞系中NOTCH3信号由其细胞外结构城累积激活
Ruihua Sun,Zhenxiang Zhao,Ningning Che et al.
Ruihua Sun et al.
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic cerebral small-vessel disease caused by NOTCH3 mutations, yet its pathogenic mechanisms remain incompletely un...
METTL14 promotes trophoblast dysfunction by elevating SZRD1 expression in an m6A-dependent manner [0.03%]
METTL14通过m6A依赖的方式上调SZRD1促进滋养细胞功能障碍
Qinglan Ye,Liyong Deng
Qinglan Ye
Preeclampsia, a common hypertensive pregnancy disorder associated with shallow trophoblast invasion, is a leading cause of perinatal and maternal mortality worldwide. Many studies have indicated that genes are differentially expressed betwe...
Bisphosphoglycerate mutase is involved in glucose metabolism and progression of nonalcoholic fatty liver disease based on liver organoids [0.03%]
基于肝器官型的 bisphosphoglycerate 变位酶参与非酒精性脂肪性肝病中的葡萄糖代谢及疾病进展
Zheng Zhou,Xiyan Zheng,Xianqing Chen et al.
Zheng Zhou et al.
This study seeks to investigate the underlying mechanism of glycolytic key gene bisphosphoglycerate mutase (BPGM) in nonalcoholic fatty liver disease (NAFLD). qRT-PCR and immunohistochemistry were utilized to detect BPGM levels in clinical ...
NR1H4 downregulation facilitates abnormal cell proliferation contributing to IgA nephropathy pathogenesis, with potential clinical implications [0.03%]
NR1H4下调促进异常细胞增殖并参与IgA肾病发病机制，具有潜在的临床意义
Xian Li,Wen Yang,Changxi Sun
Xian Li
IgA nephropathy (IgAN) is a common glomerulonephrites worldwide. We herein aimed to investigate the pathogenic mechanisms underlying IgAN and to identify hub targets. The IgAN-related datasets were derived from the Gene Expression Omnibus d...
Deciphering the immunological landscape of HR + metastatic breast cancer: insights from single-cell transcriptomics [0.03%]
揭秘HR阳性转移性乳腺癌的免疫图谱：单细胞基因组学带来的启示
Lifang He,Qianqian Zhao,Zexiao Chen et al.
Lifang He et al.
Breast cancer remains the leading cause of cancer-related mortality among women worldwide, primarily due to metastatic complications. The immune components of the tumor microenvironment (TME) significantly influence metastatic progression. ...
Transcriptomic landscape of oral potentially malignant disorders: a meta-analysis approach [0.03%]
口腔潜在恶性疾病的转录组谱系：一种元分析方法
Vaishnav Vasudevan,Gangotri Siddappa,Reba Elsa Sam et al.
Vaishnav Vasudevan et al.
Early detection of potentially malignant and malignant lesions in the oral cavity is mandatory for reduction in oral cancer incidence, detection at an early stage and improving survival. The objective of this study was to catalogue the tran...
Meta-Analysis
Human cell. 2026 May 4;39(5):72. DOI:10.1007/s13577-026-01373-5 2026
Heterogeneity of HTLV-1 proviral integration sites and internal structures in the ATL cell line MT-1 [0.03%]
成人T细胞白血病MT-1细胞系中人类T细胞白血病病毒I型游离DNA的整合位点及内部结构的异质性研究
Misaki Izaki,Yuki Hashikura,Kunihiko Umekita et al.
Misaki Izaki et al.
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL). The ATL-derived cell line MT-1 is used to study HTLV-1 biology and leukemogenesis. However, the proviral integration sites and internal structures of HTLV-1 are...