Clinical relevance of tumor microenvironment: immune cells, vessels, and mouse models [0.03%]
肿瘤微环境的临床意义：免疫细胞、血管和小鼠模型
Eriko Katsuta,Omar M Rashid,Kazuaki Takabe
Eriko Katsuta
The tumor microenvironment (TME) plays a crucial role in tumor progression, therapeutic response, and patient outcomes. TME includes immune cells, blood and lymphatic vessels, and so on. There are anti-cancer and pro-cancer immune cells. In...
microRNA-4270-5p inhibits cancer cell proliferation and metastasis in hepatocellular carcinoma by targeting SATB2 [0.03%]
miR-4270-5p通过靶向SATB2抑制肝癌细胞增殖和转移
Yun Wang,Chang-Feng Li,Li-Bo Sun et al.
Yun Wang et al.
Hepatocellular carcinoma (HCC) remains a lethal cancer type for both males and females. MicroRNAs (miRNAs) contribute to the initiation, development and metastasis of cancer. Although several miRNAs have been identified as drivers or suppre...
Characterization and comparative DNA methylation profiling of four adipogenic genes in adipose-derived stem cells and dedifferentiated fat cells from aging subjects [0.03%]
人间充质干细胞衰老的表观遗传学机制研究进展及展望
Kallapat Tansriratanawong,Isao Tabei,Hiroshi Ishikawa et al.
Kallapat Tansriratanawong et al.
Adipose-derived stem cells (ASCs) and dedifferentiated fat (DFAT) cells are alternative cell sources in tissue engineering and regeneration because they are easily obtained and exhibit multilineage differentiation. However, aging may attenu...
Comparative Study
Human cell. 2020 Oct;33(4):974-989. DOI:10.1007/s13577-020-00379-x 2020
Investigation of the effects of urea cycle amino acids on the expression of ALB and CEBPB in the human hepatocellular carcinoma cell line FLC-4 [0.03%]
尿素循环氨基酸对人肝癌细胞系FLC-4中ALB和CEBPB表达影响的研究
Takahiko J Fujimi,Yoshihiro Mezaki,Takahiro Masaki et al.
Takahiko J Fujimi et al.
Cell lines are powerful tools for research into liver function at the molecular level. However, they are generally unsuitable for rigorously assessing the effects of amino acid composition, because many lines require serum-containing medium...
Interleukin-22 enhances chemoresistance of lung adenocarcinoma cells to paclitaxel [0.03%]
白介素22增强肺腺癌细胞对紫杉醇的耐药性
Zhiliang Huang,Yu Gao,Dianchen Hou
Zhiliang Huang
The chemoresistance of tumors is the main barrier to cancer treatment. Interleukin-22 (IL-22) plays an important role in the chemoresistance of multi-cancers; however, the roles of IL-22 in the paclitaxel resistance of lung adenocarcinoma c...
Exosomes derived from natural killer cells inhibit hepatic stellate cell activation and liver fibrosis [0.03%]
天然杀伤细胞衍生的外泌体可抑制肝星状细胞活化和肝纤维化
Ling Wang,Yinghao Wang,Jun Quan
Ling Wang
Activation of hepatic stellate cells (HSCs) is a prominent driver of liver fibrosis. This study was designed to investigate the effect of exosomes derived from natural killer (NK) cells on HSC activation and liver fibrosis. The exosomes wer...
Biological assessment of new tetrahydroacridine derivatives with fluorobenzoic moiety in vitro on A549 and HT-29 cell lines and in vivo on animal model [0.03%]
含氟苯甲酸结构的新四氢吖啶衍生物的体外抗A549和HT-29细胞系活性及动物模型体内评估
Karol Kłosiński,Małgorzata Girek,Kamila Czarnecka et al.
Karol Kłosiński et al.
A new series of tetrahydroacridine derivatives with the fluorobenzoyl moiety was synthesized and evaluated for cytotoxic activity against lung cancer cell lines A549 and colorectal cancer HT29. The cytotoxic activity of the compounds was co...
LncRNA HCG18 is critical for vascular smooth muscle cell proliferation and phenotypic switching [0.03%]
长链非编码RNA HCG18对血管平滑肌细胞增殖和表型转换至关重要
Yanjiao Lu,Jingjing Guo,Shengnan Zhu et al.
Yanjiao Lu et al.
Previous studies have shown that some specific long non-coding RNAs are dysregulated in vascular walls and abnormally expressed in vascular disease. LncRNA HLA complex group 18 (HCG18) is a member of the HLA complex group, which has been ra...
Progress in the treatment of osteoarthritis with umbilical cord stem cells [0.03%]
胎盘cord干细胞治疗骨关节炎的进展
Hanguang Liang,Haiqiang Suo,Zhiwei Wang et al.
Hanguang Liang et al.
Osteoarthritis is a chronic degenerative joint disease with an incidence of 81% among people aged over 65 years in China. Osteoarthritis significantly decreases the quality of life of patients, causing physical and psychological damage and ...
Tricyclic antipsychotics promote adipogenic gene expression to potentiate preadipocyte differentiation in vitro [0.03%]
三环抗精神病药促进脂肪生成基因表达以增强前脂肪细胞分化（体外）
Christopher M Cottingham,Taylor Patrick,Morgan A Richards et al.
Christopher M Cottingham et al.
Antipsychotic-induced weight gain is a well-established but poorly understood clinical phenomenon. New mechanistic insights into how antipsychotics modulate adipose physiology are sorely needed, in hopes of either devising a therapeutic int...