Tumor promoting effects of glucagon receptor: a promising biomarker of papillary thyroid carcinoma via regulating EMT and P38/ERK pathways [0.03%]
通过调节EMT和P38 / ERK途径促进肿瘤的作用： glucagon受体作为乳头状甲状腺癌的有希望的生物标志物的作用
Hong-Chun Jiang,Xiang-Ru Chen,Hai-Feng Sun et al.
Hong-Chun Jiang et al.
Glucagon is a crucial hormone involved in the maintenance of glucose homeostasis. Large efforts to define the role of glucagon receptor (GCGR) have been continuously made in recent years, but it is still incomplete about its function and me...
Hirsutella sinensis inhibits NLRP3 inflammasome activation to block aristolochic acid-induced renal tubular epithelial cell transdifferentiation [0.03%]
雷丸菌抑制NLRP3炎性小体活化以阻断马兜铃酸致肾小管上皮细胞转分化
Min Yu,Yu-Lin Man,Meng-Hua Chen et al.
Min Yu et al.
In recent years, kidney damage caused by ingestion of Chinese medicinal herbs containing Aristolochic acid (AA) has attracted extensive attention. However, whether the nephrotoxicity of AA is related to NLRP3 inflammasome has not been repor...
LncRNA MYCNOS facilitates proliferation and invasion in hepatocellular carcinoma by regulating miR-340 [0.03%]
长链非编码RNA MYCNOS通过调控miR-340促进肝癌细胞增殖和侵袭
Junfeng Yu,Zhejian Ou,Yangyang Lei et al.
Junfeng Yu et al.
Hepatocellular carcinoma (HCC) remains one of the most common and aggressive human cancers worldwide. Accumulating evidences indicate that non-coding RNAs are critical regulators implicated in various physiological processes including HCC d...
miR-663b promotes colorectal cancer progression by activating Ras/Raf signaling through downregulation of TNK1 [0.03%]
microRNA-663b通过下调TNK1激活Ras/Raf信号促进结直肠癌进展
Sen Hong,Zhenkun Yan,Helei Wang et al.
Sen Hong et al.
MiR-663b has been demonstrated to be abnormally expressed in several cancer types and was involved in the progression of cancer. Although overexpression of miR-663b in colorectal cancer was observed, the role of miR-663b in colorectal cance...
Exploring the effect of epigenetic modifiers on developing insulin-secreting cells [0.03%]
表观遗传修饰物对诱导生成胰岛素分泌细胞的影响研究
Ibrahim Elsharkawi,Divyasree Parambath,Maha Saber-Ayad et al.
Ibrahim Elsharkawi et al.
Diabetes is a worldwide health problem with increasing incidence. The current management modalities did not succeed to decrease comorbidities. This study aimed at enhancing the regenerative solution for diabetes by improving the differentia...
Risk factors associated with the development of moderate to severe chronic graft-versus-host disease after non-myeloablative conditioning allogeneic stem cell transplantation in patients with AML or MDS [0.03%]
非清髓性预处理异基因干细胞移植后慢性移植物抗宿主病进展为中/重度的风险因素分析（急性髓系白血病和骨髓增生异常综合症患者）
Laurence M C Kok,Laura Bungener,Geertruida H de Bock et al.
Laurence M C Kok et al.
Moderate to severe chronic graft-versus-host disease (cGVHD) is associated with high morbidity, hospital dependency and poor quality of life. In this study, we analyzed a well-defined consecutive series of 98 patients with acute myelogenous...
Gene expression and DNA methylation changes in BeWo cells dependent on tumor necrosis factor-α and insulin-like growth factor-I [0.03%]
肿瘤坏死因子-α和胰岛素样生长因子-I依赖的贝沃细胞基因表达及DNA甲基化变化
Kei Tanaka,Kazuhiko Nakabayashi,Tomoko Kawai et al.
Kei Tanaka et al.
Pregnant women with increased insulin resistance, characterized by elevated levels of tumor necrosis factor-alpha (TNF-α) and insulin-like growth factor-I (IGF-I), are at high risk of preeclampsia. We hypothesized that TNF-α and IGF-I aff...
LINC00174 down-regulation decreases chemoresistance to temozolomide in human glioma cells by regulating miR-138-5p/SOX9 axis [0.03%]
LINC00174通过调节miR-138-5p/SOX9轴降低胶质瘤细胞对替莫唑胺的耐药性
Bin Li,Haikang Zhao,Jianming Song et al.
Bin Li et al.
Temozolomide (TMZ) is one of the most common drugs selected for glioma chemotherapy, but the therapeutic effect of glioma treatment is usually limited due to its resistance. Long non-coding RNA (lncRNA) is gradually found to be a vital regu...
CCND1 silencing suppresses liver cancer stem cell differentiation through inhibiting autophagy [0.03%]
CCND1沉默通过抑制自噬抑制肝癌干细胞分化
Hongying Zhang
Hongying Zhang
Liver cancer stem cells (LCSCs) are responsible for the carcinogenesis, recurrence, metastasis and chemoresistance of hepatocellular carcinoma (HCC). This study aimed to explore the role of CCND1 (Cyclin D1), an oncogene in HCC, in regulati...
Circ_ANKIB1 stabilizes the regulation of miR-19b on SOCS3/STAT3 pathway to promote osteosarcoma cell growth and invasion [0.03%]
circ_ANKIB1通过稳定miR-19b对SOCS3/STAT3通路的调节促进成骨细胞瘤细胞增殖和侵袭
Yi-Xin Du,Lin-Xin Guo,Han-Song Pan et al.
Yi-Xin Du et al.
Osteosarcoma is a highly malignant tumor. The molecular mechanism of its occurrence and development has not yet been clarified. Current studies have found that noncoding RNAs, such as circular RNAs (circRNAs) and microRNAs (miRNAs), play im...