ODC1 loss upon KLF6 upregulation promotes macrophage pyroptosis and acute kidney injury in sepsis [0.03%]
KLF6上调介导的ODC1丢失促进脓毒症中的巨噬细胞焦亡及急性肾损伤
Jiansheng Ding,Shijie Zhang,Xiangxian Zhang
Jiansheng Ding
The excessive inflammatory cascade in sepsis represents a major cause of multiorgan injuries, including sepsis-associated acute kidney injury (SAKI). Following the bioinformatics prediction, this study aims to investigate the role of ornith...
tRNA-derived small RNAs: emerging regulators of ferroptosis in human diseases [0.03%]
tRNA衍生的small RNA：人类疾病中铁死亡的新兴调节因子
Jiqing Zhang,Mu Liu,Zhongjun Li
Jiqing Zhang
tRNA-derived small RNAs (tsRNAs) are functional non-coding RNAs that play crucial roles in transcriptional, translational, and epigenetic regulation. Ferroptosis is an iron-dependent form of programmed cell death driven by lipid peroxidatio...
A stem cell-based toolkit to model Angelman syndrome caused by paternal uniparental disomy of chromosome 15 [0.03%]
基于干细胞的工具包用于建模由于15号染色体父系单亲二倍体导致的天使人综合症
Francisca Cazaux Mateus,João Camões Dos Santos,Maria Arez et al.
Francisca Cazaux Mateus et al.
Angelman syndrome is a rare neurodevelopmental disorder caused by the loss of function of the maternally inherited UBE3A gene within the chr15q11-q13 region. This gene is subjected to a tissue-specific form of genomic imprinting leading to ...
Samanmitha Srinivasa,Shuchi Odiyanda Charmanna,Rachana Rajesh Nayak et al.
Samanmitha Srinivasa et al.
The liver is the largest internal organ. Several critical functions are attributed to the liver which include metabolism, synthesis of serum proteins, excretion, detoxification, and various physiological processes essential for maintaining ...
Establishment of KGAS, a cell line derived from gastric-type adenocarcinoma of the uterine cervix [0.03%]
宫颈胃型腺癌细胞系KGAS的建立
Hiroaki Yamada,Akira Yokoi,Eri Asano-Inami et al.
Hiroaki Yamada et al.
Gastric-type adenocarcinoma (GAS) of the uterine cervix is a rare and aggressive subtype of cervical adenocarcinoma characterized by intrinsic resistance to chemotherapy and poor clinical outcomes due to the lack of effective treatment opti...
The SWI/SNF chromatin remodeling complex subunit BAF53B as an immunohistochemical marker for neuroendocrine neoplasms [0.03%]
BAF53B作为神经内分泌肿瘤免疫组化标志物的研究及其在肺癌中的临床应用研究
Kouhei Sakurai,Mako Ochiai,Kanata Kojima et al.
Kouhei Sakurai et al.
The Switch/Sucrose Nonfermentable (SWI/SNF) complexes are chromatin remodeling factors that consist of multiple protein subunits. Each subunit plays a distinct role in gene regulation and is aberrantly expressed in tumors, such as neuroendo...
Apigenin inhibits endothelial-to-mesenchymal transition of coronary artery endothelial cells and myocardial fibrosis by regulating ribosome biogenesis through GTPBP4 modulation [0.03%]
染色质重塑蛋白GTPBP4调控核糖体生成，黄酮类化合物Apigenin通过该途径抑制冠状动脉内皮细胞上皮间质转化及心肌纤维化
Xiaoyong Hu,Zhaoying Yang,Rui Tang et al.
Xiaoyong Hu et al.
Myocardial fibrosis is a complex pathological process that often leads to myocardial dysfunction, heart failure, and ultimately, death. A critical contributor to the development of cardiac fibrosis is the endothelial-to-mesenchymal transiti...
Correction: Long non-coding RNA DUXAP10 exerts oncogenic properties in osteosarcoma by recruiting HuR to enhance SOX18 mRNA stability [0.03%]
长非编码RNA DUXAP10通过招募HuR增强SOX18 mRNA稳定性在骨肉瘤中发挥致癌作用的修正观点
Guantong Wang,Qian Zhang,Qinjue Wang et al.
Guantong Wang et al.
Published Erratum
Human cell. 2025 Sep 12;38(6):156. DOI:10.1007/s13577-025-01281-0 2025
SIRT1 as a potential target for age-related eye diseases: mechanisms and therapeutic strategies [0.03%]
SIRT1可能是年龄相关性眼病的治疗靶点：机制和治疗策略
Huirui Liu,Yuting Ouyang,Hongyan Ge
Huirui Liu
Age-related eye diseases (AREDs) are the leading cause of visual impairment in the elderly, affecting the structure of the anterior and posterior segments of the eye, significantly reducing the quality of life of patients, and even leading ...
USF1-induced RPS6KB2 activation influences aggressive phenotype in B-cell non-Hodgkin lymphoma [0.03%]
USF1通过激活RPS6KB2影响B细胞非霍奇金淋巴瘤的侵袭表型
Zhaoyu Liu,Xiang Song,Zhuang Liu et al.
Zhaoyu Liu et al.
B-cell non-Hodgkin lymphoma (B-NHL) is a diverse group of aggressive lymphoid malignancies characterized by its molecular complexity. This study investigated the role of the upstream stimulatory factor 1 (USF1)-ribosomal protein S6 kinase B...