A novel HPV E6/E7-regulated long noncoding RNA CRL suppresses cervical intraepithelial neoplasia progression by attenuating ferroptosis [0.03%]
一种新型HPV E6/E7调控的长链非编码RNA CRL通过抑制铁死亡来抑制宫颈上皮内瘤变进展
Ting Zhang,Yanan Yan,Shuai Yuan et al.
Ting Zhang et al.
Sustained human papillomavirus (HPV) infection induces cervical intraepithelial neoplasia (CIN), a well-established precursor lesion and risk factor for cervical cancer. However, the specific long noncoding RNAs (lncRNAs) that regulate CIN ...
Effects of ABCG2 dysfunction on hyperuricemia progression in premenopausal and postmenopausal women [0.03%]
ABCG2功能障碍对绝经前和绝经后妇女高尿酸血症进展的影响
Yuka Miyoshi,Akiyoshi Nakayama,Hiroshi Nakashima et al.
Yuka Miyoshi et al.
Serum uric acid (SUA) levels are influenced by environmental and genetic factors, such as sex and ABCG2 variants. Their poorlyunderstood links to menstrual status prompted us to conduct this study to evaluate the effects of menstrual status...
BMAL1 regulates the initial step of embryo implantation by modulating endometrial cell adhesion and migration [0.03%]
BMAL1通过调节子宫内膜细胞黏附和迁移来调控胚胎着床的初始步骤
Keita Imai,Yidan Dai,Masanori Ono et al.
Keita Imai et al.
Embryo implantation is a critical and tightly regulated process essential for successful human reproduction. Although the role of endometrial receptivity is well established, the molecular mechanisms governing this process are not thoroughl...
Indole-3-acetic acid promotes differentiation while suppressing proliferation in human intestinal epithelial cells [0.03%]
吲哚-3-乙酸促进人类肠上皮细胞分化同时抑制增殖
Marta Mallardo,Furqan Memon,Raffaella Pagliaro et al.
Marta Mallardo et al.
Indole-3-acetic acid (IAA) is a tryptophan-derived microbial metabolite increasingly recognized for its role in intestinal homeostasis, immune regulation, and epithelial function. However, the IAA molecular effects on intestinal epithelial ...
Immune imbalance in rheumatoid arthritis: insights from γδ T cell receptor phenotyping [0.03%]
γδT细胞受体分型在类风湿关节炎免疫失衡中的意义
Sylwia Biały,Joanna Wielińska,Kinga Maria Tyczyńska et al.
Sylwia Biały et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint destruction. While conventional αβ T cells have been extensively studied, the contribution of γδ T cells t...
The potential of bioengineered exosomes in regenerative medicine: a next generation therapy [0.03%]
生物工程外泌体在再生医学中的潜力：下一代疗法
Shiwani Kumari,Anjali Agnihotri,Arpit Sharma et al.
Shiwani Kumari et al.
The limitations of conventional drug delivery systems and synthetic nanocarriers have spurred the search for advanced therapeutic platforms in regenerative medicine. Bioengineered exosomes/sEV, natural extracellular vesicles with inherent b...
Thiolutin attenuates neuroinflammation and neuronal apoptosis by suppressing microglial pyroptosis through NLRP3 inflammasome inhibition after spinal cord injury [0.03%]
硫洛丁因通过NLRP3炎性小体抑制抑制脊髓损伤后的微胶质细胞焦亡以此减轻神经炎症和神经元凋亡
Yifan Zeng,Lijuan Zhao,Shuxia Qian
Yifan Zeng
Traumatic spinal cord injury (SCI) initiates a neuroinflammatory response dominated by tissue-resident microglia. Thiolutin (THL) can weaken several inflammatory diseases by blocking the NOD-, LRR-, and pyrin domain-containing protein 3 (NL...
FUS modulates R-loops by functionally interacting with RNase H1 [0.03%]
FUS通过功能上与RNase H1相互作用来调节R环结构
Anusree Dey,Rituparna Das,Sheetal Uppal
Anusree Dey
R-loops are three-stranded nucleic acid structures consisting of an RNA:DNA hybrid and a displaced single-stranded DNA, typically formed during transcription. Emerging evidence indicates that R-loops are not merely transcriptional byproduct...
Integrative analysis of lncRNAs associated with disulfidptosis-related genes for prognostic risk evaluation and tumor immune microenvironment assessment in laryngeal squamous cell carcinoma [0.03%]
整合分析与二硫化依赖性相关基因相关的长链非编码RNA，以评估喉部鳞状细胞癌的预后风险和肿瘤免疫微环境
Qinghua Liu,Zesheng Zhang,Yingli Xie et al.
Qinghua Liu et al.
Disulfidptosis, an emerging metabolism-associated regulated cell death pathway, involves tumor progression via the modulation of redox homeostasis. Long noncoding RNAs (lncRNAs) are promising for tumor prognostic models, but prognostic mode...
miR-141-5p positively regulates ACVRL1 expression to promote cervical cancer progression [0.03%]
miR-141-5p通过正向调控ACVRL1促进宫颈癌进展
Jianbing Liu,Yongzhi Jiao,Jinjuan Wang et al.
Jianbing Liu et al.
Global cancer data show a continuous rise in cervical cancer incidence and mortality, burdening public health. To effectively mitigate this challenge, elucidating molecular pathogenesis and novel drug targets are critical for advancing clin...