Mert Gayretli,Jacob H Hanna
Mert Gayretli
A universal 6iL/E4 culture system for deriving and maintaining embryonic stem cells across mammalian species [0.03%]
一种用于跨哺乳动物物种的胚胎干细胞分离和维持的通用6iL/E4培养系统
Duo Wang,Hao Ming,Dongshan Yang et al.
Duo Wang et al.
The derivation of authentic embryonic stem cells (ESCs) across mammalian species remains a major challenge. Here, we report the development of a defined, serum-free culture system, termed 6iL/E4, that enables the derivation and long-term se...
A new era of lineage tracing [0.03%]
谱系追踪的新纪元
Kathy O Lui,Bin Zhou
Kathy O Lui
Genome-wide profiling of histone modifications and transcription factor binding at single-cell resolution by DeChIC-seq [0.03%]
单细胞分辨率下DeChIC-seq绘制组蛋白修饰和转录因子结合的全基因组图谱
Zhifei Shi,Xiyang Chen,Yijia Yang et al.
Zhifei Shi et al.
Mapping of protein-DNA interactions at single-cell resolution remains a central challenge in epigenomics, particularly for transcription factors (TFs), whose sparse binding limits reliable detection. Here, we establish DeChIC-seq (DNA Deami...
Bishwa Ranjan Si,Debanik Choudhury,Sanjiban Nath et al.
Bishwa Ranjan Si et al.
Yvonne L Latour,Dorian B McGavern
Yvonne L Latour
Atypical signaling, ligand recognition and selective agonist discovery of complement receptor C5aR2 [0.03%]
补体受体C5aR2非典型激活机制、配体识别与偏向性激动剂发现
Jiao Qin,Chenxi Cai,Mayu Shan et al.
Jiao Qin et al.
C5a, the most potent anaphylatoxin in the complement system, exerts its effects through the canonical G protein-coupled receptor C5aR1 and the arrestin-coupled receptor C5aR2. Despite the critical role of C5aR2 in immunomodulation, the mole...
One drug, five targets [0.03%]
一个药物五种作用靶点
Haipeng Fu,Alan R Saltiel
Haipeng Fu
Smooth emotional response: amygdalar neurovascular coupling drives stress encoding [0.03%]
平滑的情绪反应：杏仁体神经血管耦合驱动应激编码
Alice Cadoret,Luisa Bandeira Binder,Caroline Menard
Alice Cadoret
Tian-Gen Chang,Eldad D Shulman,Eytan Ruppin
Tian-Gen Chang