Silk fibroin-based nanocarriers for anticancer drug delivery: advances, mechanisms, and future perspectives [0.03%]
基于丝素蛋白的抗癌药物递送纳米载体：进展、机制和未来展望
Qinjing He,Dongmei Li,Yuanyuan Xu et al.
Qinjing He et al.
Cancer remains a critical global health challenge, with conventional chemotherapy limited by systemic toxicity, poor bioavailability, and lack of tumor specificity. This review comprehensively explores silk fibroin (SF)-a natural, biocompat...
Antibacterial activity of Cerium Oxide Nanoparticles: a systematic review and meta-analysis study [0.03%]
纳米氧化铈的抗菌活性：系统评价和Meta分析研究
Sajjad Jabermoradi,Parsa Paridari,Joanna Shepherd et al.
Sajjad Jabermoradi et al.
Introduction: This meta-analysis examined the antibacterial efficacy of Cerium Oxide Nanoparticles (CeO2 NPs) through statistical analysis of published data. ...
Augmenting sonodynamic therapy with single-atom nanoenzyme via tumor microenvironment-mediated reactive oxygen species generation [0.03%]
基于肿瘤微环境介导的活性氧生成的单原子纳米酶增强体声动力学疗法
Jing Yang,Qing Ji,Wenrong Zhu et al.
Jing Yang et al.
While remarkable strides have been made in personalized precision oncology, integrating diagnosis and therapy within a unitary theranostic platform remains a pivotal challenge. Sonodynamic therapy (SDT), which leverages ultrasound to activa...
Advances in the applications of stimulus-responsive nanomedicines for anti-cancer therapy [0.03%]
刺激响应型纳米药物在癌症治疗中的应用进展
Xianwen Tan,Shan Wang,Xiaoyu Zhou et al.
Xianwen Tan et al.
Current major cancer therapies are limited by nonspecific drug distribution and severe off-target toxicity. Nanomedicine has emerged as a promising strategy for targeted tumor drug delivery, leveraging nanoparticles' unique properties to en...
Donguk Kim,Augustine Duffy,Alex Wee et al.
Donguk Kim et al.
Influenza remains a major global health concern, with the ongoing seasonal epidemics causing millions of cases and up to 650,000 deaths worldwide annually. Current influenza vaccines only provide strain-specific and short-lived protection, ...
Angelea Maestas-Olguin,Maya M Dawson,Emily Rhoades Clark et al.
Angelea Maestas-Olguin et al.
Utilization of endogenous RNA interference (RNAi) mechanisms via delivery of exogeneous small interfering RNA (siRNA) molecules offers a transformative approach to treatment of disease by enabling sequence specific silencing of mutated gene...
Inhibition of calreticulin by protein nanoparticles carrying antisense oligonucleotides reduce gene expression and infection of Trypanosoma cruzi trypomastigotes on mammalian cells [0.03%]
载有反义寡核苷酸的蛋白质纳米颗粒抑制钙网蛋白减少宿主细胞中锥虫感染及其基因表达
B Prestegui-Martel,I Martínez,R E Cárdenas-Guerra et al.
B Prestegui-Martel et al.
Background: Chagas disease, caused by the parasite Trypanosoma cruzi, is a neglected tropical disease that impacts millions of individuals. At least two drugs directed against the parasite (Benznidazole and Nifurtimox) ha...
Engineered extracellular vesicles for nose-to-brain co-delivery of chlorotoxin and curcumin for treatment of glioblastoma [0.03%]
用于治疗胶质母细胞瘤的氯毒素和姜黄素鼻脑共递送工程外泌体
Mincheol Son,Jae Young Park,Subin Kang et al.
Mincheol Son et al.
Aim: Extracellular vesicles (EVs) were developed as a co-delivery carrier of curcumin and chlorotoxin (CTX) into the brain. Materials & methods: ...
Advancing melanoma treatment with nanoparticles: from chemotherapy to combination therapies [0.03%]
纳米颗粒在黑色素瘤治疗中的应用：从化疗到联合疗法
Chou-Yi Hsu,Suleiman Ibrahim Mohammad,Asokan Vasudevan et al.
Chou-Yi Hsu et al.
Nanoparticle (NPs)-based therapies have ushered in a paradigm shift in melanoma treatment, addressing key challenges in conventional chemotherapy and immunotherapy, such as drug delivery, specificity, and therapeutic efficacy. This review h...
Evaluation of PTX/Mo2CTx-MXene@Fuc surface-engineered nanosheets in targeted combination therapy for triple-negative breast cancer [0.03%]
PTX/Mo2CTx-MXene@Fuc表面工程纳米片在三阴性乳腺癌靶向联合治疗中的评价研究
Derya Özel,Ayça Tunçel,Gül Kaya et al.
Derya Özel et al.
Aims: The study aimed to evaluate the multifunctional therapeutic potential of PTX/Mo2CTx-MXene@Fuc combinations, emphasizing their performance in drug loading, release kinetics, oxidative stress induction, apoptosis, cel...