Rajnish Kumar,Nishant R Sinha,Nikhil M Karupathi et al.
Rajnish Kumar et al.
Drug delivery in cornea remains a challenge due to its unique dome shape, anatomy, epithelial barrier, rapid drug clearance, and eyelid blinking. Nanoscale-based drug delivery systems are particularly attractive for treating corneal disease...
Advances in the development and application of nanofibrous systems for intranasal drug delivery [0.03%]
纳米纤维系统在鼻用药物递送方面的研发进展及其应用
Angeliki Koimtzidou,Konstantina Chachlioutaki,Dimitrios G Fatouros
Angeliki Koimtzidou
Intranasal drug delivery has emerged as an attractive noninvasive route for local, systemic, and central nervous system (CNS) therapy due to its rapid absorption, avoidance of first-pass metabolism, and potential for nose-to-brain transport...
Bacterial extracellular vesicles: mechanisms, engineering strategies, and therapeutic potential for inflammatory bowel disease [0.03%]
细菌外泌体：机制、工程策略及在炎症性肠病治疗中的潜力
Qing Ji,Huabiao Chen,Xiaochun Sun
Qing Ji
Clinical management of inflammatory bowel disease (IBD) is hampered by limited therapeutic targets, primary non-response, secondary loss of efficacy, and safety risks, which undermine clinical outcomes. Probiotics and postbiotics represent ...
Debadatta Mohapatra,Timothy W Corson
Debadatta Mohapatra
Conventional therapeutics (eye drops, injectables, ointments, gels) for ocular diseases face several challenges, including low ocular permeability, rapid clearance, low bioavailability, and off-target effects due to complex anatomical barri...
Evolution of peptide-mediated siRNA delivery - from early design to next generation platform [0.03%]
肽介导的小干扰核糖核酸递送的演变——从早期设计到下一代平台技术
Michael Y T Chow,Jenny K W Lam
Michael Y T Chow
Small interfering RNA (siRNA) therapeutics has huge potential for treating many diseases, including those incurable or undruggable by small molecules or antibodies, by harnessing RNA interference (RNAi) to achieve specific silencing of dise...
Advances in carbohydrate polymer-based stimuli-responsive nanocarriers: precision strategies for overcoming multidrug resistance in targeted cancer therapy [0.03%]
基于碳水化合物聚合物的刺激响应型纳米载体的研究进展：精准策略克服靶向治疗中多药耐药性问题
Muhammad Liaquat Raza,Alam Shah,Habibun Nisa et al.
Muhammad Liaquat Raza et al.
Multidrug resistance (MDR) remains a formidable challenge in cancer therapy, often rendering conventional chemotherapeutics ineffective. Recent advances in carbohydrate polymer-based stimuli-responsive nanocarriers have opened new avenues f...
Radiolabeling of clinically approved nanomedicine carriers: lessons from albumin- and liposome-based systems for biomaterial design and translational imaging [0.03%]
临床批准的纳米药物载体的放射性标记：血清白蛋白和脂质体系统在生物材料设计和转化成像中的经验教训
Ye Ri Han,Sang Bong Lee
Ye Ri Han
Radiolabeling is a powerful approach for investigating the in vivo behavior of nanomedicine carriers beyond conventional pharmacokinetic analysis. This review examines clinically approved nanocarrier platforms, particularly albumin-bound na...
Qianqian Huang,Fei Luan,Junbo Zou et al.
Qianqian Huang et al.
Aims: To investigate whether non‑cytotoxic Au NPs induce reversible structural remodeling of multiple organelles, and to provide a basis for redefining biocompatibility assessment and nanocarrier design. ...
Next-generation stealth lipid-based nanocarriers: advances in PEGylation and emerging amide-containing polymer alternatives [0.03%]
下一代隐身脂质基纳米载体：PEG修饰及新兴酰胺类聚合物替代品的研究进展
Manon Degey,Stefano Pedergnana,Brigitte Evrard et al.
Manon Degey et al.
Surface chemistry affects the in vivo behavior of lipid-based nanocarriers, through lipid-PEGylation (polyethylene glycol, PEG), which forms a steric barrier at the nanoparticle interface and extends systemic circulation. This is relevant f...
Quantitative phase imaging analysis of silica nanoparticle-induced macrophage recovery and functionality [0.03%]
定量相显微镜分析二氧化硅纳米颗粒诱导的巨噬细胞恢复和功能性的研究
Sushanto Kumar Saha,Shukran Alizada,Thomas A Zangle et al.
Sushanto Kumar Saha et al.
Aim: Uptake of nanoparticles by macrophages has long been a significant concern for systemically delivered nanoparticle-based therapeutics. While the accumulation of nanoparticles in macrophages reduces the availability o...