Advancing nanomedicine with machine learning: predicting protein corona and nano-bio interactions [0.03%]
Alexa Canchola,Keyuan Li,Kunpeng Chen et al.
Alexa Canchola et al.
The protein corona (PC) has widely been demonstrated to impact the pharmacokinetics, safety, and efficiency of nanoparticle (NP) systems for clinical applications such as drug or vaccine delivery. However, a comprehensive understanding of P...
Engineering perspectives on nano-micro structural design of gold and mesoporous silica nanoparticle imaging systems for tumor diagnosis and in vivo cell tracking [0.03%]
Sang Bong Lee
Sang Bong Lee
Nanoparticle-based imaging systems are increasingly used for tumor diagnosis and in vivo cell tracking due to their tunable physicochemical properties and high imaging sensitivity. Among inorganic platforms, gold nanoparticles (AuNPs) and m...
Anuradha Kumari,Siddhant Kumar,Rahul Shukla
Anuradha Kumari
One of the biggest causes of morbidity and mortality in the world today is sepsis, primarily due to dysregulated host responses that culminate in systemic inflammation, oxidative stress, and progressive multi-organ failure. Conventional the...
Macrophage membrane-encapsulated liposomes of protopanaxadiol-type doxorubicin hydrochloride improve formulation stability for the treatment of triple-negative breast cancer [0.03%]
Xinxin Bai,Zhixia Wang,Yawen Yu et al.
Xinxin Bai et al.
Aims: The use of macrophage membrane-encapsulated protopanaxadiol (PPD)-type doxorubicin hydrochloride liposomes provides an innovative solution to improve the drug stability of DOX and enhance its antitumor effect. ...
A multifunctional lipid-lowering nanotherapeutic alleviates lipid deposition associated microglial dysfunction [0.03%]
Jiyao Xie,Yining Liu,Jiamei Xie et al.
Jiyao Xie et al.
Aim: Microglial lipid deposition is increasingly recognized as a critical feature of disturbed lipid homeostasis, and lipid droplet driven pathological cascades can reinforce oxidative and mitochondrial stress, creating a...
Spatiotemporal cancer control via alternating magnetic field -activated nanoantennae: coupling heat, electron transport, and immune reprogramming [0.03%]
Thrinayan Moorthy,Shang-Hsiu Hu
Thrinayan Moorthy
Magnetic-field-responsive nanoparticles (MFR-NPs) have evolved from traditional magnetic hyperthermia agents into conductive nanomaterials that combine catalytic therapy with electrical current generation under alternating magnetic fields (...
Natural killer cells labeled with radionuclide-embedded double-layer gold nanoparticles conjugated to a mitochondrial localization sequence for PET/CT imaging and NK cell-based immunotherapy [0.03%]
内嵌放射性核素的双层金纳米颗粒标记自然杀伤细胞用于正电子发射断层及计算机体层摄影融合成像和基于自然杀伤细胞的免疫治疗
Sang Bong Lee,Yong Hyun Jeon
Sang Bong Lee
Background: Noninvasive, sensitive monitoring of natural killer (NK) cells in vivo remains challenging due to limited nanoparticle uptake. We developed a radionuclide-embedded double-layer gold nanoparticle (RI-DLGNP) pla...
Heparin-functionalized chitosan-poly(ε-caprolactone) nanoparticles loaded with quinine for selective targeting of infected erythrocytes and enhanced antiplasmodial efficacy [0.03%]
肝素功能化的壳聚糖-聚（己内酯）载奎宁纳米颗粒用于感染红细胞的选择性靶向及抗疟活性的增强
Yohana Amos,Rami Ahmed,Elingarami Sauli et al.
Yohana Amos et al.
Aims: Malaria remains a major global health burden, particularly in sub-Saharan Africa. Although quinine (QN) is an effective antimalarial, its clinical application is limited by dose-dependent toxicity from nonspecific b...
Current challenges in the development of liposomes to target mitochondria [0.03%]
当前针对线粒体脂osome开发所面临的挑战
Shrey Shah,Gerard G M D&#x;Souza
Shrey Shah
Although liposomes have been shown to be capable of mediating the delivery of therapeutics to mitochondria, clinical translation has yet to be realized. This short, focused review outlines some major challenges and offers hypotheses that wa...
Toxicological assessment of intraperitoneal administration for Au nanorods with ultra-small Pt nanoparticles on surface (Au@pt NRs) in mice [0.03%]
超小型Pt纳米颗粒修饰的金棒对小鼠的毒理学评估
Aiyun Yang,Tao Wen,Jie Meng et al.
Aiyun Yang et al.
Aims: Ultra-small Pt NPs on Au nanorods (Au@Pt NRs) is a typical bimetallic nanomaterial. Due to their superior optical and catalytic ability, they are widely investigated in biomedical fields. However, the toxicity has n...