Evolution of peptide-mediated siRNA delivery - from early design to next generation platform [0.03%]
肽介导的小干扰核糖核酸递送的演变——从早期设计到下一代平台技术
Michael Y T Chow,Jenny K W Lam
Michael Y T Chow
Small interfering RNA (siRNA) therapeutics has huge potential for treating many diseases, including those incurable or undruggable by small molecules or antibodies, by harnessing RNA interference (RNAi) to achieve specific silencing of dise...
Advances in carbohydrate polymer-based stimuli-responsive nanocarriers: precision strategies for overcoming multidrug resistance in targeted cancer therapy [0.03%]
基于碳水化合物聚合物的刺激响应型纳米载体的研究进展：精准策略克服靶向治疗中多药耐药性问题
Muhammad Liaquat Raza,Alam Shah,Habibun Nisa et al.
Muhammad Liaquat Raza et al.
Multidrug resistance (MDR) remains a formidable challenge in cancer therapy, often rendering conventional chemotherapeutics ineffective. Recent advances in carbohydrate polymer-based stimuli-responsive nanocarriers have opened new avenues f...
Radiolabeling of clinically approved nanomedicine carriers: lessons from albumin- and liposome-based systems for biomaterial design and translational imaging [0.03%]
临床批准的纳米药物载体的放射性标记：血清白蛋白和脂质体系统在生物材料设计和转化成像中的经验教训
Ye Ri Han,Sang Bong Lee
Ye Ri Han
Radiolabeling is a powerful approach for investigating the in vivo behavior of nanomedicine carriers beyond conventional pharmacokinetic analysis. This review examines clinically approved nanocarrier platforms, particularly albumin-bound na...
Qianqian Huang,Fei Luan,Junbo Zou et al.
Qianqian Huang et al.
Aims: To investigate whether non‑cytotoxic Au NPs induce reversible structural remodeling of multiple organelles, and to provide a basis for redefining biocompatibility assessment and nanocarrier design. ...
Next-generation stealth lipid-based nanocarriers: advances in PEGylation and emerging amide-containing polymer alternatives [0.03%]
下一代隐身脂质基纳米载体：PEG修饰及新兴酰胺类聚合物替代品的研究进展
Manon Degey,Stefano Pedergnana,Brigitte Evrard et al.
Manon Degey et al.
Surface chemistry affects the in vivo behavior of lipid-based nanocarriers, through lipid-PEGylation (polyethylene glycol, PEG), which forms a steric barrier at the nanoparticle interface and extends systemic circulation. This is relevant f...
Quantitative phase imaging analysis of silica nanoparticle-induced macrophage recovery and functionality [0.03%]
定量相显微镜分析二氧化硅纳米颗粒诱导的巨噬细胞恢复和功能性的研究
Sushanto Kumar Saha,Shukran Alizada,Thomas A Zangle et al.
Sushanto Kumar Saha et al.
Aim: Uptake of nanoparticles by macrophages has long been a significant concern for systemically delivered nanoparticle-based therapeutics. While the accumulation of nanoparticles in macrophages reduces the availability o...
Longitudinally cultured precision cut lung slices as a predictive ex vivo model for metastatic lung cancer [0.03%]
长期培养的精确切割肺片作为转移性肺癌的预测性体外模型
Ara Sargsian,Hermon Girmatsion,Vincent Lenders et al.
Ara Sargsian et al.
Aim: Exploring alternatives to in vivo models, this study validates Precision Cut Lung Slices (PCLS) as a viable ex vivo platform for lung cancer research. We established the prolonged viability and structural preservatio...
Navigating the translational Valley of death in oncology nanotheranostics: manufacturing, biological, clinical, and regulatory barriers to implementation [0.03%]
肿瘤纳米治疗诊断技术转化过程中的制造、生物学、临床和监管障碍
Esther Ugo Alum,David Chukwu Obasi,Simon Uzor et al.
Esther Ugo Alum et al.
Nanotheranostics integrate diagnostic and therapeutic functions within nanoscale platforms and have emerged as promising tools for precision oncology by enabling image-guided drug delivery, real-time biodistribution tracking, treatment moni...
Optimized curcumin-loaded anionic niosomes for intranasal delivery: enhanced ex vivo nasal permeation and cytotoxicity against neuroblastoma [0.03%]
一种优化的姜黄素阴离子鼻用尼osome递送系统：增强的透皮吸收和对神经母细胞瘤的细胞毒性
Alaa R Al Jayoush,Jayalakshmi Jagal,Muna B Najm et al.
Alaa R Al Jayoush et al.
Aims: To develop and evaluate a Quality-by-Design (QbD) optimized curcumin-loaded niosomal (OptCUR-NS) formulation for intranasal delivery and determine its delivery performance and in vitro activity against neuroblastoma...
Targeting USP7 - a nano-therapeutic approach to restore and reactivate P53 for promoting apoptosis in glioma therapy [0.03%]
靶向USP7——用于恢复和重新激活P53以促进胶质瘤治疗中细胞凋亡的纳什疗法
Sunny Kumar,Mrinal K Ghosh
Sunny Kumar
Background: Glioblastoma remains one of the most lethal brain malignancies due to its profound molecular heterogeneity, invasive biology, and poor drug penetration across the BBB. Clinically, USP7 is highly overexpressed ...