Antimicrobial nanocoatings and films for contact lenses: progress and promise [0.03%]
隐形眼镜的抗菌纳米涂层和薄膜：进展与前景
Manjulatha Sara,Samuel Attard,Naresh Kumar et al.
Manjulatha Sara et al.
Introduction: Microbial keratitis is a serious complication of contact lens wear, occurring in 2-24 cases per 10,000 wearers annually. Increasing lens use, especially for myopia control in children, highlights the need fo...
How has the inclusion of unconventional lipids improved LNP-mediated mRNA delivery? [0.03%]
非传统脂质的纳入是如何改进LNP介导的mRNA递送的？
Mingsen Zhou,Jingyan Chen,Ziling Zheng et al.
Mingsen Zhou et al.
Lipid nanoparticles (LNPs) have become the leading platform for mRNA delivery, exemplified by the success of mRNA vaccines. However, LNPs composed of classical lipid materials are still constrained by intrinsic hepatotropism and suboptimal ...
Filipa Ramos,Girish Kumar,Tarun Virmani et al.
Filipa Ramos et al.
Mishita Akter,Manman Wang,Chenyu Liu et al.
Mishita Akter et al.
Malignant cancer remains the leading cause of mortality globally, and advancements in nanotechnology-driven nanomedicine are expected to yield promising alternative therapeutic strategies. Dendrimers, as synthetic polymers, possess a broad ...
Dual-functional nanoparticle formulations for simultaneous intraocular pressure reduction and neuroprotection in glaucoma: a review [0.03%]
用于同时降低眼内压和神经保护的双功能纳米颗粒制剂(GLAUCOMA的文献回顾)
Lei Xu,Yang Hu,Xiaorong Liu et al.
Lei Xu et al.
Glaucoma is a leading cause of irreversible blindness, driven by elevated intraocular pressure (IOP), progressive retinal ganglion cell (RGC) loss, and optic nerve degeneration. Current therapies rely on lowering IOP, which slows but does n...
Anti-apoptotic effects of ruthenium nanozyme-augmented adipose stem cells accelerate cutaneous wound healing [0.03%]
抗凋亡钌纳米酶增强脂肪干细胞加速创面修复的作用
Zhangqiang Wu,Daoqiang Huang,Jiashui Xie et al.
Zhangqiang Wu et al.
Introduction: The failure of conventional therapies for diabetic wounds, including those relying solely on stem cells or antioxidants, stems from an inability to simultaneously overcome the hostile microenvironment charac...
Designing drug delivery systems: the impact of structural order and disorder for optimized therapeutic outcomes [0.03%]
药物输送系统的结构设计：以最佳疗效为导向的有序与无序结构的影响研究
Alessandro Masoero,Marzia Conte,Nicolò Maria Percivalle et al.
Alessandro Masoero et al.
The implementation of drug delivery systems in nanomedicine aims to improve the efficacy, safety and stability of therapeutic substances within the body, while controlling their rate and time of release. While numerous reviews over the year...
Silver nanoparticle-antimicrobial peptide supramolecular nanocomposite coating improves implant osseointegration under mechanical loading [0.03%]
银纳米粒子-抗菌肽超分子纳米复合涂层改善机械载荷下植入物的骨整合
Huihui Wang,Nicholas G Fischer,Yunlin Guan et al.
Huihui Wang et al.
Background: Long-term implant success depends on preventing infection and achieving initial stability, yet many antimicrobial coatings impair osseointegration, and most animal models overlook the impact of mechanical load...
An AlFu MOF nanoadjuvant functionalized with mannose for potential dendritic-cell targeting and dual TLR9-STING activation [0.03%]
一种潜在的树突状细胞靶向和双重TLR9-STING激活的甘露糖改性的AlFu MOF纳米佐剂
Weixia Li,Yang Sun,Yi Guan et al.
Weixia Li et al.
Background: Aluminum adjuvants remain the most widely used adjuvants in licensed vaccines. Their broader application, however, is restricted by local and systemic adverse effects and limited antigen compatibility, slowing...
Hydrogels for acne treatment: a systematic review and meta-analysis of clinical trials [0.03%]
用于治疗痤疮的水凝胶：临床试验的系统评价和荟萃分析
Shaden Abunasser,Salma Younes,Nijad R Mina et al.
Shaden Abunasser et al.
Aim: Hydrogels are three-dimensional, water-rich polymer networks that enhance drug delivery, hydration, and tolerability in topical acne therapy. This systematic review and meta-analysis evaluated the efficacy and safety...