Applying dendrimer nanoprobes to the diagnosis and evaluation of kidney fibrosis [0.03%]
应用树枝状分子纳米探针进行肾脏纤维化的诊断与评估研究
Xiaoxu Li,Leyuan Xu
Xiaoxu Li
Renal fibrosis is the central pathological process driving the progression of chronic kidney disease (CKD), representing a major global health burden. Current diagnostics, like biopsy, are invasive and lack the sensitivity for early, repeat...
Advancing prussian blue nanoparticle-mediated photothermal therapy through machine learning and multiomics integration [0.03%]
通过机器学习和多组学整合推进普鲁士蓝纳米粒子介导的光热疗法
Vanessa F Merino,Namya Saini,Rohan Fernandes
Vanessa F Merino
Prussian blue nanoparticles (PBNPs) are a versatile platform for administering photothermal therapy (PTT) in cancer therapy applications. PBNPs combine biocompatibility, safety, and clinical translational potential with durable treatment ou...
Yaodong Miao,Chun Li,Yadi Su et al.
Yaodong Miao et al.
As an efficient genome-editing technology, Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-CRISPR-associated protein9 (Cas9) system is increasingly being recognized as a significant therapeutic strategy for brain diseases....
The application of exosomes derived by mesenchymal stem cell from different tissues in the management of Alzheimer's disease [0.03%]
来源于不同组织的间充质干细胞衍生外泌体在阿尔茨海默病治疗中的应用研究
Chao Gao,Yan Li,Bo Zhou et al.
Chao Gao et al.
With the intensifying global trend of population aging, the treatment of Alzheimer's disease (AD) faces significant challenges. Current therapeutic approaches can only temporarily alleviate symptoms without halting or reversing disease prog...
Precise atorvastatin delivery by cardiac homing peptide functionalized nanoliposomes for myocardial damage repair after myocardial infarction [0.03%]
一种具有心肌定位肽的阿托伐他汀纳米脂质体用于急性心梗后的心肌损伤修复
Hongqin Yu,Shuai Li,Hongtao Niu et al.
Hongqin Yu et al.
Objective: To develop a novel lipid nanoparticle (Ato@DSPE-PEG-CHP) for targeted delivery to ischemic myocardium to treat myocardial infarction. Methods: ...
Tamoxifen-loaded TPGS-PLGA nanoplatform for breast cancer therapy: insights into drug delivery, distribution, treatment efficacy, and ultrasound/photoacoustic imaging [0.03%]
用于乳腺癌治疗的加载他莫昔芬TPGS-PLGA纳米递药平台：药物递送、分布、治疗效果及超声/光声成像研究
Dipali Patil,Vaishali,Nandini Vinodrao Randhave et al.
Dipali Patil et al.
Aims: The objective of the present study was to develop and characterize tamoxifen (TAM)-loaded TPGS-PLGA nanoparticles (NPs) for more effective breast cancer treatment than conventional therapy. ...
M2-sEVs-based immunotherapy for alleviation of osteoarthritis-related pain by regulating synovial macrophage NGF expression via the NOTCH pathway [0.03%]
基于M2-sEVs的免疫疗法通过NOTCH信号调节滑膜巨噬细胞NGF表达来缓解骨关节炎相关性疼痛
Jiashuo Liu,Luhao Sun,Lei Luo et al.
Jiashuo Liu et al.
Aim: Osteoarthritis (OA) is a prevalent degenerative joint disease characterized primarily by chronic pain. Currently, there are no highly effective treatments for OA pain. This study aimed to assess the efficacy of M2 ma...
Applications of engineered peptide nanomaterials in enhanced cancer imaging [0.03%]
工程化肽纳米材料增强肿瘤成像中的应用
Chloe E Shenouda,Tiana V Sharpe,Jacob W Campbell et al.
Chloe E Shenouda et al.
In this review, applications of engineered peptide nanomaterials in enhanced cancer imaging are summarized, focusing on the most pertinent of reports. The design principles of said peptide nanostructures are outlined as well as their functi...
Caroline R Fox,Sheryl A Loden,Kelsey P Kubelick
Caroline R Fox
Cell-derived therapies represent a rapidly growing field for treating various diseases. Serving as "living" medicines, these therapies involve the use of live cells that can be engineered with added therapeutic benefits to treat various dis...
Precision nanomedicine against pulmonary tuberculosis: the role of lipid-based drug delivery systems [0.03%]
针对肺结核的精准纳米药物治疗：脂质载药体系的作用
Nathan He,Kevin Dong,William Lee et al.
Nathan He et al.
Tuberculosis (TB) is one of the world's leading causes of death and continues to pose a major global public health challenge. Caused by Mycobacterium tuberculosis, TB most commonly presents as pulmonary disease and is primarily treated with...