Phase I first-in-human dose-escalation trial of a bladder cancer-specific nanoparticle in non-muscle-invasive bladder cancer [0.03%]
膀胱癌纳米颗粒递药系统治疗非肌层浸润性膀胱肿瘤的I期临床试验
Chong-Xian Pan,Matthew Mossanen,Jeffrey L Ellis et al.
Chong-Xian Pan et al.
Objectives: Non-muscle-invasive bladder cancer (NMIBC) refractory to Bacillus Calmette-Guérin (BCG) treatment recurs frequently, even with recent approved therapies. We developed a novel, solvent-free, cancer-specific na...
From conventional formulations to nanoparticles in the delivery of Imiquimod: a literature review [0.03%]
伊米喹莫德递送方式的研究进展：从传统制剂到纳米药物体系
Hamoud Alotaibi,Mona Al Hamod,Mohammed Aljuaid et al.
Hamoud Alotaibi et al.
Imiquimod (IMQ) is an FDA-approved immune response modifier available as a 5% w/w topical cream (Aldara™) and is extensively utilized in the treatment of superficial basal cell carcinoma and other skin cancers. PubMed and Google Scholar (2...
Lipid-based nanocarriers as transformative treatment in tuberculosis: a systematic review of therapeutic efficacy [0.03%]
基于脂质的纳米载体作为治疗结核病的变革性疗法：疗效系统综述
Nur Afifah Othman,Mohd Cairul Iqbal Mohd Amin,Hui Yin Yow et al.
Nur Afifah Othman et al.
Aim: Despite advances in global medicine, tuberculosis (TB) remains a leading cause of mortality worldwide. The current TB regime is hampered by prolonged treatment duration that frequently results in poor patient adheren...
UCMSC-Exo for chemotherapy-induced myelosuppression in acute myeloid leukemia: a phase I clinical trial protocol [0.03%]
乌司他丁人源化单链骆驼抗体修饰的外泌体治疗急性髓系白血病化疗所致骨髓抑制：I期临床试验方案
Di Wu,Wenjuan He,Jing He et al.
Di Wu et al.
Myelosuppression induced by chemotherapy represents a critical bottleneck for patients with hematological malignancies, leading to a series of severe complications responsible for chemotherapy dose reduction, interruptions, and even treatme...
Aptamer-functionalized nanoparticles for cancer targeting: conjugation strategies, current applications and future perspectives [0.03%]
用于癌症靶向的适配体功能化纳米颗粒：连接策略、当前应用和未来前景
Laura Cerchia,Emanuela Bua,Letizia Sambri et al.
Laura Cerchia et al.
Aptamers have emerged as highly versatile targeting ligands for nanomedicine due to their small size, low immunogenicity, and programmable chemical modification. Their integration into nanoparticle-based systems has enabled precise molecula...
Targeted therapy of highly aggressive thyroid papillary carcinoma by AS1411-guided nanomaterials [0.03%]
AS1411引导的纳米材料针对高度侵袭性甲状腺乳头状癌的靶向治疗
Yinghou Wang,Qikun Jiang,Guozheng Liu et al.
Yinghou Wang et al.
Aims: Aggressive papillary thyroid carcinoma (PTC) is often refractory to radioiodine therapy, and effective targeted therapeutic strategies are urgently needed. This study aimed to construct an AS1411 aptamer-guided gold...
Impacts of curcumin nanoemulgel on cell viability and apoptotic pathways: a comprehensive study of ROS generation across different skin cancer cell lines [0.03%]
姜黄素纳米乳胶对细胞活力和凋亡途径的影响：不同皮肤癌细胞系中ROS生成的全面研究
Joshna Booravilli,Janaki Devi Sirisolla
Joshna Booravilli
Objective: Conventional curcumin formulations, such as gels, creams, and oral dosage forms, have poor solubility and bioavailability, limiting its therapeutic efficiency. Therefore, the primary objective of this research ...
Advancements in single-chain antibody functionalized nanoparticles for the treatment of advanced solid tumors [0.03%]
单链抗体功能化纳米颗粒治疗晚期实体瘤的研究进展
Tara Wieben,Horacio Bach
Tara Wieben
Cancer therapeutics for solid tumors remain limited by the low specificity and high rates of multidrug resistance of conventional chemotherapy. Immunotherapy offered a potential solution to these challenges; however, monoclonal antibody tre...
Next-generation intranasal delivery nano-platforms for targeted brain therapy of Alzheimer's disease [0.03%]
下一代鼻内递送纳米平台针对阿尔茨海默病的脑部治疗靶向性研究
Akanksha Malaiya,Rameshroo Kenwat,Aanjaneya Mamgain et al.
Akanksha Malaiya et al.
Introduction: Alzheimer's disease (AD) is a progressive neurodegenerative disorder that poses a growing global health burden. Effective drug delivery to the brain is largely constrained by the selective nature of the bloo...
Controlling nanoparticle targeting: from physicochemical design to molecular recognition [0.03%]
纳米颗粒靶向递送的调控：从物理化学设计到分子识别
Antonella Rocchi,Luca Marchetti,Paolo Decuzzi et al.
Antonella Rocchi et al.
Nanomedicine has revolutionized drug delivery, providing innovative nanodelivery platforms that enhance biodistribution, targeting, precision, and therapeutic efficacy across a wide range of pathological conditions. The design of nanopartic...