Self-assembled influenza a neuraminidase virus-like particle vaccination confers protection against influenza B virus [0.03%]
自组装流感A型神经氨酸酶病毒样颗粒疫苗对流感B型病毒具有保护作用
Gi-Deok Eom,Ki Back Chu,Keon-Woong Yoon et al.
Gi-Deok Eom et al.
Background: Neuraminidase has gained increasing attention as a broadly reactive influenza vaccine antigen capable of mitigating the strain-specific limitations of hemagglutinin-based vaccines. ...
Doxorubicin-loaded perfluoropentane nanodroplets enhance radiofrequency ablation efficacy by relieving tumor hypoxia [0.03%]
载多柔比星的全氟戊烷纳米气泡通过缓解肿瘤低氧增强射频消融疗效
Yang Tan,Lin Wang,Yu Duan et al.
Yang Tan et al.
Aims: Radiofrequency ablation (RFA) is a common treatment for malignant tumors, yet recurrence and metastasis persist a major challenge. The hypoxic microenvironment induced by RFA is a key driver of residual tumor aggres...
Smart oral delivery of curcumin nanoparticulate systems for targeted colorectal cancer therapy: strategies, applications, and future perspectives [0.03%]
智能口服递送姜黄素纳米颗粒系统用于结直肠癌靶向治疗：策略、应用和未来展望
Yuxuan Zhu,Tianyu Wu,Yuxing Fu et al.
Yuxuan Zhu et al.
Colorectal cancer (CRC) offers a unique opportunity for oral nanomedicine due to its anatomical location and distinct physiological gradients. Curcumin (CUR) demonstrates immense therapeutic potential against CRC but is limited by poor solu...
Subconjunctival injection of novel antioxidant nanoparticles inhibits neovascularization after corneal injury [0.03%]
新型抗氧化纳米颗粒的亚conjunctival注射可抑制角膜损伤后的新生血管化
Jilin Zhou,Shuyi Hou,Xiaojue Wang et al.
Jilin Zhou et al.
Objective: To mitigate corneal neovascularization, we developed antioxidant nanoparticles (BP@CS) that sustainably inhibit the overexpression of reactive oxygen species (ROS) after corneal chemical injury. ...
When small gets smart: how the application of nanotechnology is transforming immunology in the 21st Century [0.03%]
当小型技术变得聪明：纳米技术在21世纪免疫学中的应用如何转变免疫学
Marina A Dobrovolskaia
Marina A Dobrovolskaia
Tremendous progress has been made over the past two decades in understanding how nanoparticles interact with the immune system. This knowledge was used to improve research tools in basic immunology and to develop novel nanotechnology-enable...
SHED-derived exosomes ameliorate age-related osteoporosis by activating mitophagy in senescent bone marrow mesenchymal stem cells [0.03%]
外泌体通过激活衰老骨髓间充质干细胞的线粒体自噬来缓解年龄相关的骨质疏松症
Kuan Yang,Baize Zhang,Yingyue Zhang et al.
Kuan Yang et al.
Aim: This study aims to explore the therapeutic efficacy of stem cells from human exfoliated deciduous teeth-derived exosomes (SHED-Exo) in age-related osteoporosis (OP) and clarify its mechanism via mitophagy activation ...
Inhalable gene and RNA therapy for cystic fibrosis: perspectives and progress in clinical development [0.03%]
吸入给药的基因和RNA疗法治疗囊性纤维化：临床开发前景及进展
Miftakul Munir,Neville J Butcher,Rhiannon B Werder et al.
Miftakul Munir et al.
Small molecule modulators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) play a key role in cystic fibrosis (CF) management. Around 10% of people with CF (pwCF), however, are ineligible for modulator therapy. Inhalable CF...
Nanocarriers for potential treatment of sensorineural hearing loss and retinitis in congenital cytomegalovirus [0.03%]
纳米载体有望用于先天性巨细胞病毒的感觉神经性聋和视网膜炎的治疗
Mary Daniel,Horacio Bach
Mary Daniel
Congenital cytomegalovirus (cCMV), which results from in utero transmission of CMV, is associated with devastating pediatric sequelae, including sensorineural hearing loss and retinitis. Current treatment guidelines suggest treatment with i...
Tian Yun,Yujie Hu,Yihui Deng et al.
Tian Yun et al.
Ischemic stroke (IS), as a cerebrovascular disease caused by interrupted blood supply to the neurons, results in a high prevalence of disability and mortality worldwide. Traditional treatment methods including antithrombotic and neuroprotec...
Wojciech G Lesniak,Martin G Pomper
Wojciech G Lesniak
Dendrimers represent a unique category of polymeric macromolecules characterized by a well-defined architecture that begins with a central core, expands through regularly repeating branching units, and terminates in a dense array of surface...