Biomimetic keratin gold nanoparticle-mediated in vitro photothermal therapy on glioblastoma multiforme [0.03%]
仿角蛋白金纳米颗粒介导的原代胶质母细胞瘤光热治疗
Alexa Guglielmelli,Paolo Rosa,Marco Contardi et al.
Alexa Guglielmelli et al.
Aim: To realize and characterize a new generation of keratin-coated gold nanoparticles (Ker-AuNPs) as highly efficient photosensitive nanosized therapeutics for plasmonic photothermal (PPT) therapy. Materials & methods: The chemical, physic...
Synthesis of mussel-inspired polydopamine-gallium nanoparticles for biomedical applications [0.03%]
受贻贝启发的聚多巴胺-镓纳米颗粒的合成及其生物医学应用
Jean Valdir Uchôa Teixeira,Fátima Raquel Azevedo Maia,Mariana Carvalho et al.
Jean Valdir Uchôa Teixeira et al.
Aim: To established a simple, controlled and reproducible method to synthesize gallium (Ga)-coated polydopamine (PDA) nanoparticles (NPs). Materials & methods: PDA NPs were synthesized in alkali medium with posterior Ga shell formation due ...
Epigallocatechin-3-gallate PEGylated poly(lactic-co-glycolic) acid nanoparticles mitigate striatal pathology and motor deficits in 3-nitropropionic acid intoxicated mice [0.03%]
聚乙二醇化儿茶素纳米粒缓解3-硝基丙酸致小鼠纹状体病理损害和运动缺陷
Amanda Cano,Miren Ettcheto,Marta Espina et al.
Amanda Cano et al.
Aim: To compare free and nanoparticle (NP)-encapsulated epigallocatechin-3-gallate (EGCG) for the treatment of Huntington's disease (HD)-like symptoms in mice. Materials & methods: EGCG was incorporated into PEGylated poly(lactic-co-glycoli...
TNF-α detection using gold nanoparticles as a surface-enhanced Raman spectroscopy substrate [0.03%]
利用表面增强拉曼光谱基底的金纳米颗粒检测TNF-α
Elizabeth Loredo-García,Alejandra Ortiz-Dosal,Juan Manuel Núñez-Leyva et al.
Elizabeth Loredo-García et al.
Background: TNF-α is a cytokine involved in inflammation. Surface-enhanced Raman spectroscopy (SERS) could be useful in its detection. Aim: Identify the TNF-α in an aqueous solution, using gold nanoparticles (AuNPs) as a SERS substrate. M...
Mariana Amaral,Ana B Pereiro,Maria Manuela Gaspar et al.
Mariana Amaral et al.
In drug discovery and drug development, it is estimated that around 40% of commercialized and 90% of under-study drugs have inadequate pharmaceutical properties, severely impairing its therapeutic efficacy. Thus, there is a strong demand to...
Hydrogel-nanoparticle hybrids for biomedical applications: principles and advantages [0.03%]
用于生物医学应用的水凝胶-纳米粒子杂化材料：原理及优势
Nur Shahirah Sulaiman,Nurasyikin Hamzah,Siti Fatimah Zakaria et al.
Nur Shahirah Sulaiman et al.
Magnetic polymeric nanobubbles with optimized core size for MRI/ultrasound bimodal molecular imaging of prostate cancer [0.03%]
一种用于前列腺癌磁共振成像和超声波模态分子成像的具有优化核心尺寸的磁性聚合物微气泡
Yunkai Zhu,Ying Sun,Weiyong Liu et al.
Yunkai Zhu et al.
Aim: To design MRI/ultrasound (US) dual modality imaging probes with optimized size for prostate cancer imaging by targeting prostate-specific membrane antigen (PSMA). Materials & methods: The PSMA-targeting polypeptide-nanobubbles (PP-NBs)...
Albumin-based lipoprotein nanoparticles for improved delivery and anticancer activity of curcumin for cancer treatment [0.03%]
基于白蛋白的类脂质体纳米颗粒用于提高姜黄素输送及抗癌活性以治疗癌症
Preeti Kumari,Milan Paul,Yamini Bobde et al.
Preeti Kumari et al.
Aim: To prepare curcumin (CUR)-loaded, dioleoyl phosphoethanolamine-conjugated human serum albumin nanoparticles (NPs) and to evaluate their effectiveness in breast cancer therapy. Materials & methods: The CUR-loaded NPs were physicochemica...
New proposal involving nanoformulated melatonin targeted to the mitochondria as a potential COVID-19 treatment [0.03%]
针对线粒体的纳米配方褪黑素作为潜在COVID-19治疗药物的新建议
Virna Margarita Martín Giménez,Natalia Prado,Emiliano Diez et al.
Virna Margarita Martín Giménez et al.
Curcumin-loaded niosomes downregulate mRNA expression of pro-inflammatory markers involved in asthma: an in vitro study [0.03%]
姜黄素载尼osome下调哮喘相关促炎标记物的mRNA表达：一项体外研究
Jin-Ying Wong,Zhao Yin Ng,Meenu Mehta et al.
Jin-Ying Wong et al.
Aim: In this study, curcumin was encapsulated in niosomes (Nio-Curc) to increase its effectiveness for the treatment of asthma. Materials & methods: The formulation underwent various physicochemical characterization experiments, an in vitro...