A new way to modulate tumor therapy: artificial intelligence predicts nanoshape efficacy [0.03%]
一种新的肿瘤治疗调控方式：人工智能预测纳米形状疗效
Jie Dai,Jianmei Li,Bengui Ye et al.
Jie Dai et al.
Cancer remains one of the leading causes of death worldwide, and its treatment continues to present significant challenges. Nanomedicines have shown remarkable potential in cancer therapy; however, research on their delivery still faces sev...
Simultaneous co-delivery of a reporter EGFP gene and doxorubicin to HepG2 cells using AuNPs-Functionalized Graphene Oxide Nanostructures [0.03%]
利用AuNPs功能化石墨烯纳米结构同时共递送EGFP基因和多柔比星到HepG2细胞中
Sanaz Hosseini,Ali Khorsand Zak,Abbas Nikravesh et al.
Sanaz Hosseini et al.
Aims: Hepatocellular carcinoma (HCC) ranks among the leading causes of cancer-related mortality worldwide. While doxorubicin (DOX) demonstrates efficacy, its associated toxicity is considerable, necessitating innovative s...
Nano-icilin-driven TRPM8 activation elicits immunogenic exosomes with antitumor effects [0.03%]
纳米级冰片通过激活TRPM8诱导出具有抗肿瘤作用的免疫小体
Ghasem Noorkhajavi,Salar Hemmati,Mehdi Shahgolzari et al.
Ghasem Noorkhajavi et al.
Background: Transient receptor potential melastatin 8 (TRPM8) is a cold-sensing cation channel that regulates calcium (Ca2+) levels in cells. Its overexpression is linked to tumor development and progression. TRPM8 activa...
Nanoemulsions as carriers for malignant brain tumors treatment: a scoping review on drugs, natural compounds, and siRNA delivery [0.03%]
纳米乳作为恶性脑肿瘤治疗载体：药物、天然化合物及siRNA递送的系统综述
Betina Montanari Beltrame,Patrícia Weimer,Bruna Medeiros-Neves et al.
Betina Montanari Beltrame et al.
Malignant brain tumors are a highly complex and heterogeneous group of neoplasms, with glioblastoma being the most aggressive and treatment-resistant form. Standard therapies remain insufficient, largely due to poor drug penetration across ...
Quantitative proteomic and phenotypic responses of urinary pathogens to CuO/Cu₂O nanoparticles [0.03%]
CuO/Cu₂O纳米粒子对尿路病原菌定量蛋白质组学和表型的影响响应
Kidon Sung,Miseon Park,Ohgew Kweon et al.
Kidon Sung et al.
Aims: To evaluate the antibacterial efficacy of pulsed laser ablation-generated copper oxide (CuO/Cu₂O) nanoparticles (NPs) against urinary pathogens and to elucidate molecular stress responses through proteomic profilin...
Cancer targeting carfilzomib nanomedicine: a comprehensive review of delivery vehicles and efficacy [0.03%]
卡非佐米抗癌纳米药物：递送载体与疗效的全面综述
Matthew Molinaro,Dipanjan Pan
Matthew Molinaro
Cancer therapy is an ever-changing landscape in constant demand of innovative approaches. Carfilzomib (CFZ) is a tetrapeptide epoxyketone covalent proteasome inhibitor currently approved for the treatment of refractory multiple myeloma. CFZ...
Jiaqi Huang,Theepa Thivaharan,Yi Liu et al.
Jiaqi Huang et al.
Development and characterization of multifunctional dendrimeric nanoconjugates for delivery of rutin: in vitro characterization for potential neuroprotective application [0.03%]
用于递送芦丁的多功能树状纳米载体的开发及表征：体外神经保护作用特征研究
Abhishek Sonwani,Anchal Pathak,Keerti Jain
Abhishek Sonwani
Aim: In the present research work, multifunctional dendrimeric nanoconjugates were developed, where poly(amidoamine) dendrimer generation 4.0 (G4.0) was conjugated with folic acid and N-acetyl cysteine simultaneously to d...
The rationality guidance index: a framework for reducing redundancy in nanomedicine innovation [0.03%]
理性的指导指数：减少纳米医学创新中冗余的框架
Aliasgar Shahiwala
Aliasgar Shahiwala
Nanocarriers have transformed drug delivery by improving bioavailability, enabling targeted action, and reducing systemic toxicity. Despite these advances, the field has become saturated with structurally and functionally similar platforms,...
Stiripentol-loaded self-nanoemulsifying delivery system for glioblastoma: therapeutic efficacy in 3D spheroid and xenograft model [0.03%]
载有司替戊醇的自纳米乳化递送系统治疗胶质母细胞瘤：三维球体和异种移植模型中的疗效研究
Anjali Yadav,Himaxi Patel,Shraddha Bhutkar et al.
Anjali Yadav et al.
Aim: To develop, formulate, and evaluate stiripentol (STP)-loaded Self-Nano Emulsifying Drug Delivery System (SNEDDS) for its potential as a Glioblastoma (GBM) therapeutic. ...