Enzymatic cell-surface engineering with glycocalyx mimicking anti-oxidant and anti-inflammatory sulfated polymers for protection against inflammatory vascular injury [0.03%]
利用模拟糖萼的抗炎抗氧化硫酸化多聚物进行酶催化细胞表面工程以抵抗血管炎症损伤
Haiming D Luo,Md Mohosin Rana,Peyman Malek Mohammadi Nouri et al.
Haiming D Luo et al.
The endothelial glycocalyx is among the earliest cellular components disrupted during inflammatory vascular injury, where oxidative stress and inflammatory signaling drive endothelial dysfunction. Current therapeutic strategies remain limit...
Superparamagnetic nanoparticles' potential in hyperthermia therapy and targeted drug delivery systems [0.03%]
超顺磁性纳米颗粒在热疗和靶向药物递送系统中的潜力
Heba AlRefaey,Fayed A Megahed,Kareem Abdelrahman et al.
Heba AlRefaey et al.
Cancer is among the fatal diseases that affect individuals worldwide. According to World Health Organization statistics, if the current trends continue, the world will see a significant increase in cancer cases over the next two decades, le...
Oral chitosan/alginate nanoparticles for enhanced bioavailability, intestinal retention, and sustained analgesic efficacy of NANT [0.03%]
用于提高NANT口服生物利用度、肠道滞留和长效镇痛功效的壳聚糖/海藻酸纳米颗粒
Lei Jiang,Yue Chen,Hao Lv et al.
Lei Jiang et al.
Snake venom proteins have attracted considerable attention as oral analgesics owing to their definite analgesic effects and lack of tolerance or addiction. Herein, we report the successful development of an optimized oral analgesic nanopart...
Chondrogenic differentiation of human periosteum-derived cells in spheroids, HAMA hydrogels, and bioprinted constructs: Comparison of kartogenin and TGF-β1 [0.03%]
人骨外膜细胞在类球体、HAMA水凝胶和生物打印结构中的软骨分化：Kartogenin与TGF-β1的比较研究
Ane Albillos Sanchez,Maria Paula Marks,Martyna Nikody et al.
Ane Albillos Sanchez et al.
Kartogenin (KGN) is a small molecule reported to promote chondrogenesis and inhibit hypertrophic differentiation in mesenchymal stromal cells (MSCs), but its effect on human periosteum-derived cells (hPDCs) remains unexplored. This study in...
Bioactive wound dressings for diabetic foot ulcers: Mechanisms, materials, and clinical translation [0.03%]
糖尿病足溃疡的活性伤口敷料：机制、材料和临床转化
Xue Wang,Nana Xiong,Huilin Hu et al.
Xue Wang et al.
Diabetic foot ulcers (DFU) represent a severe and challenging complication of diabetes, where healing is impaired by neuropathy, vascular dysfunction, persistent inflammation, and oxidative stress. Conventional therapies, including debridem...
Novel printing strategy for high fidelity extrusion-based bioprinted multi-material nested models [0.03%]
一种用于高保真度挤出式生物打印多材料嵌套模型的新颖打印策略
Maialen Zelaia Amilibia,Uxue Aizarna-Lopetegui,Laura Pérez Sánchez et al.
Maialen Zelaia Amilibia et al.
Recent advances in drug development and tissue engineering have emphasized the need for precise 3D-printed multilayered blood vessel biomodels. Although existing extrusion-based models integrate biomaterials and cells, they often lack geome...
Investigating the mechanical characteristics, microstructure, biodegradation, and in vitro biocompatibility potential of HAp-assisted, nano-scale TiO2@Al2O3strengthen Sr-reinforced Mg-Zn composite for internal fracture fixation [0.03%]
用于内固定治疗骨折的HAp辅助型纳米TiO2@Al2O3强化Sr掺杂Mg-Zn复合材料的力学性能、微观结构、生物降解性和体外生物相容性研究
Joy Saha,Kaushik Pal
Joy Saha
This study develops a hybrid-reinforced magnesium (Mg) composite for orthopedic implants by incorporating bioactive hydroxyapatite (HAp) and inert TiO2@Al2O3 nanoparticles. HAp is synthesized via controlled precipitation, while TiO2-coated ...
Resource-efficient decellularization of human iliac arteries using a 3D-printed radial-flow bioreactor: CFD-guided design and experimental validation [0.03%]
基于CFD的径向流动生物反应器设计和实验验证高效去细胞人髂动脉
Juan Odin Ramírez,Fabian Equihua Guillen,Emilio Camporredondo-Saucedo et al.
Juan Odin Ramírez et al.
Vascular bypass and reconstruction often rely on synthetic or allogeneic grafts, which may exhibit limited long-term patency and adverse host responses. Decellularized extracellular matrix (ECM) scaffolds offer a promising alternative; howe...
Innovations and optimal design in scaffold materials: The key to vascularization in bone tissue engineering [0.03%]
骨组织工程中血管化的关键在于支架材料的创新和最佳设计
Yan He,Xiao Liu,Shicong Chen et al.
Yan He et al.
Bone defects resulting from physiological or pathological processes are common in clinical practice, and bone grafting remains the primary treatment for large defects. However, grafting procedures are associated with relatively high recurre...
Loading of EPO on hydroxyapatite/polyurethane composite scaffolds promotes osteogenesis and angiogenesis by regulating of HIF-1α/VEGF signaling [0.03%]
负载EPO的羟基磷灰石/聚氨酯复合支架通过调节HIF-1α/VEGF信号促进成骨和血管生成
Xuefei Xiang,Yufang Yang,Heyou Gao et al.
Xuefei Xiang et al.
Composite scaffolds composed of porous Polyurethane (PU) block copolymer and nano-hydroxyapatite (n-HA) have demonstrated significant potential in bone defect repair. However, the co-effect of osteogenesis and angiogenesis during the proces...