Protoporphyrin IX-loaded solid lipid nanoparticles for dual-wavelength photodynamic therapy of melanoma [0.03%]
载原卟啉IX固体脂质纳米颗粒用于黑色素瘤双波长光动力治疗
Yang Sheng,Kangyao Zhao,Peng Zhang et al.
Yang Sheng et al.
Lipid nanoparticles have emerged as promising nanocarriers for improving the delivery of both hydrophobic and hydrophilic photosensitizers and enhancing therapeutic efficacy in photodynamic therapy (PDT). In this study, a biocompatible PDT ...
S A Halim,Rozy Kamal
S A Halim
Ionizing radiation-induced physicochemical modifications in implant materials directly influence their mechanical performance, surface stability, and biocompatibility, thereby affecting the material's long-term tissue integration, inflammat...
Modulating burn wound immunity and vasculature with a photo-crosslinkable glycyrrhizic acid-ginsenoside hydrogel [0.03%]
一种可光交联的甘草酸-人参皂苷水凝胶用于调节烧伤创面免疫和血管新生
Huiwen Lu,Da Song,Shujing Wang et al.
Huiwen Lu et al.
Burn injuries create a complex wound microenvironment characterized by a persistent cytokine storm that locks macrophages in a pro-inflammatory (M1) phenotype, while thermally damaged vasculature fails to regenerate, leading to prolonged in...
Three-dimensional cell-culture systems using nanofibrillated bacterial cellulose restores drug metabolism activity in HepG2 hepatocellular carcinoma cells [0.03%]
利用纳米纤维细菌纤维素的三维细胞培养系统可恢复HepG2肝癌细胞的药物代谢能力
Hidenori Ando,Cristina Nana Amorim Matsuo,Shunsuke Akagi et al.
Hidenori Ando et al.
Three-dimensional (3D) culture more faithfully reproducesin vivo-like cell interactions and functions than conventional two-dimensional (2D) monolayers. Although HepG2 cells are widely used in drug discovery, their 2D cultures exhibit low e...
Modified chitosan-based hydrogel for sustained release of tetramethylpyrazine and polydatin to promote diabetic wound healing [0.03%]
改性壳聚糖水凝胶的制备及四甲基吡嗪与聚datin的缓释研究及其促进糖尿病创面修复的作用观察
Changle Lu,Bailei Li,Jiali Liu et al.
Changle Lu et al.
Diabetic wound healing remains a clinical challenge due to impaired repair, often leading to complications such as infection and tissue necrosis. Here, we present a novel dual-drug-loaded hydrogel formulated using oxidized hyaluronic acid (...
Multifunctional BBR/PVA@PLGA coaxial electrospun membranes with osteogenic, angiogenic and barrier activities for potential bone regeneration [0.03%]
具有成骨、促血管生成和屏障作用的多功能BBR/PVA@PLGA同轴电纺膜用于潜在的骨再生
Ling Guo,Zonghao Hu,Long Yang et al.
Ling Guo et al.
Maxillofacial bone defects present a significant clinical challenge. Although guided bone regeneration (GBR) is widely employed, the therapeutic efficacy of conventional barrier membranes remains limited due to their lack of multifunctional...
Translating 3D-printed PEEK for orthopaedic implants: Nonlinear effects of gamma sterilization on time- dependent mechanical integrity and in vivo biocompatibility [0.03%]
用于骨科植入物的3D打印peek的翻译：γ灭菌对时间依赖性机械完整性和体内生物相容性的非线性影响
Wafa&#x; AlAlaween,Abdallah Alalawin,Mahmoud Abdallat et al.
Wafa&#x; AlAlaween et al.
While fused deposition modeling (FDM) of polyether ether ketone (PEEK) has achieved regulatory acceptance and is utilized for patient-specific orthopaedic implants, the obligatory terminal sterilization via gamma irradiation raises concerns...
Contribution of biomaterials analysis to the study of extractables from neonatal central venous catheters [0.03%]
生物材料分析在研究新生儿中心静脉导管提取物中的作用
Yoann Le Basle,Valérie Sautou,Sabine Sarraute et al.
Yoann Le Basle et al.
The study of extractable chemicals is used to evaluate whether a medical device contains harmful substances susceptible to migrate and contaminate the patients they are used in. The analysis of the biomaterial itself after extraction is oft...
Replacing animal models in microsurgical training: A review and future perspectives on engineered synthetic blood vessels [0.03%]
微外科训练中用合成血管取代动物模型：现状与未来展望
Simon M Kratzer,Sushma Priya,Leo Saturnino et al.
Simon M Kratzer et al.
Microsurgical training requires high-fidelity vascular models to replace traditional training on living animals or cadavers, which face increasing ethical and logistical constraints. This review evaluates the current state of engineered syn...
Advanced guar gum/polyvinyl alcohol/CS-MnP smart hydrogel for promoting osteoblastic proliferation [0.03%]
一种促进成骨细胞增殖的高级 guar 胶/PVA/CS-MnP 智能水凝胶
Benjamín Valdez-Salas,Karen Guillén-Carvajal,Jorge Salvador-Carlos et al.
Benjamín Valdez-Salas et al.
Exposed bone fractures (EBF) require multifunctional biomaterials capable of simultaneously providing structural adaptability, physicochemical stability, and biological support under dynamic physiological conditions. In this study, a smart ...