Core-shell fibrous threads loaded with VEGF plasmid polyplexes for sustained, threshold-guided gene delivery [0.03%]
负载VEGF质粒聚复合物的核壳纤维线用于持续、阈值指导的基因输送
Farzaneh Ghasemkhah,Masoud Latifi,Afra Hadjizadeh et al.
Farzaneh Ghasemkhah et al.
Precise regulation of vascular endothelial growth factor (VEGF) delivery is essential for angiogenesis-oriented tissue engineering, because excessive or poorly controlled VEGF exposure may lead to abnormal and immature vascular structures. ...
3-Layer lung cancer invasion model for evaluating MMP-targeted anti-metastatic therapeutics [0.03%]
一种用于评估以基质金属蛋白酶(MMP)为靶标的抗转移药物的肺癌侵袭病灶模型
Gwang Myeong Kim,Yunji Lee,Sojung Park et al.
Gwang Myeong Kim et al.
Metastatic lung cancer is a leading cause of cancer mortality with invasion through the extracellular matrix (ECM) as a pivotal early step. This process is largely driven by metalloproteinases (MMPs), making them prime targets for antimetas...
Enhancement of type H vessels in bone repair of rat tibial defects treated with stromal vascular fraction-collagen sponge composites [0.03%]
改进型H血管在含SVF胶原海绵复合物治疗的桡骨缺损修复中的作用
Xieyang Mei,Chenyang Xu,Yawen Xu et al.
Xieyang Mei et al.
To address the clinical limitations of autografts and allografts in bone defect repair, this study aimed to develop a novel composite graft by combining adipose-derived stromal vascular fraction (SVF) with medical-grade collagen sponge, aim...
Emulsion-based synthesis of polycaprolactone/bioactive glass 45S5 microparticles for bone regeneration applications [0.03%]
基于乳液的聚己内酯/生物活性玻璃45S5微粒的合成用于骨再生应用程序
Mantas Liudvinaitis,Dinas Tverijonas,Ieva Simoliune et al.
Mantas Liudvinaitis et al.
Polycaprolactone (PCL) and bioactive glass 45S5 (BG) are widely employed within bone tissue engineering due to their mutually complementary properties: PCL contributes structural integrity and biodegradability, whereas BG imparts osteoinduc...
Structural and functional modification of electrospun nanofibers for wound healing [0.03%]
用于伤口愈合的电纺纳米纤维的结构和功能改性
Sarah Fakher,Ryan J Gilbert
Sarah Fakher
Effective wound repair relies on a balance of cellular and molecular processes, and conventional dressings often fall short in guiding this process beyond providing basic protection. In recent years, electrospun nanofibers have gained atten...
In situ gelling gelatin/modified starch hydrogel containing curcumin-loaded niosomes for wound healing application [0.03%]
一种用于伤口治疗的含姜黄素载尼沃姆的胶原/改性淀粉水凝胶的原位成型技术
Marziyeh Tahmasebi,Masumeh Kaveh Zenjanab,Hamieh Goshtasbi et al.
Marziyeh Tahmasebi et al.
Hydrogel dressings are one of the most appropriate agents for wound healing. Here, a novel, integrated hydrogel-based drug delivery system was developed for controlled curcumin (Cur) release for wound healing applications. To this purpose, ...
Sustainable metallic biomaterials for orthopaedic implants: a comprehensive review of biodegradable and conventional metals [0.03%]
可持续医用金属骨科植入材料：可降解和传统金属的全面综述
Nikhil Anand,Kaushik Pal
Nikhil Anand
The selection of biomaterial is crucial for the long-term success of implants. Materials that perform an adequate function and reduce negative biological responses should be taken. Due to their good mechanical strength, stainless steel, tit...
An injectable biomimetic hydrogel with tethered TGFβ3 for treatment in a rat growth plate injury model [0.03%]
一种可注射仿生凝胶在大鼠生长板损伤模型中的治疗作用研究：连接TGFβ3的作用
Elizabeth A Aisenbrey,Francisco Rodriguez Fontan,Sarah A Schoonraad et al.
Elizabeth A Aisenbrey et al.
Injury to the growth plate, a cartilage tissue found at the ends of children's long bones that is responsible for bone elongation, can result in bony repair tissue (or bony bar). The bony bar connects bone on both sides of the growth plate,...
Acupoint electrical stimulation with implantable carbon nanotube electrodes mitigates sciatic nerve injury-induced muscle atrophy [0.03%]
植入式碳纳米管电极的穴位电刺激缓解坐骨神经损伤引起的肌肉萎缩
Simin Ning,Yemao Chai,Qixuan Fu et al.
Simin Ning et al.
Sciatic nerve injury (SNI) is a common form of peripheral nerve injury that often leads to persistent atrophy of denervated skeletal muscle. To address this issue, we developed an implantable electrode made of carbon nanotube fibers (CNTFs)...
Advances in nano-delivery of natural products for cancer therapy: Mechanisms and translational strategies [0.03%]
天然产物纳米载药抗肿瘤治疗研究进展：机制与转化策略
Xiang Chen,Huibin Wu,Xinyu Pan et al.
Xiang Chen et al.
Cancer remains a major global health burden, with conventional monotherapies often constrained by recurrence, resistance, and systemic toxicity. Natural products derived from plants, animals, microorganisms, and minerals exhibit broad antic...