Nonwoven nanofibrous PLA/SiO2-gelatin/hydroxyapatite hybrid scaffolds by two-nozzle electrospinning: bone tissue engineering applications [0.03%]
双喷头电纺非织造纳米级PLA/硅凝胶/羟基磷灰石杂化支架：骨组织工程应用
Marziyeh Ranjbar-Mohammadi,Roghayeh Ebrahimzadeh,Elnaz Esmizadeh et al.
Marziyeh Ranjbar-Mohammadi et al.
This study presents the fabrication and optimization of poly(lactic acid)/gelatin (PLA/Gel) composite nanofibrous scaffolds simultaneously reinforced with hydroxyapatite (HA) and silica (SiO₂) nanoparticles using a dual-nozzle electrospinn...
3D Printed 13-93B3 borate bioactive glass/hydroxypropyl methyl cellulose/gelatin scaffolds with cerium oxide submicrometric particles for potential bone regeneration [0.03%]
含CeO₂纳米颗粒的13-93B3硼酸盐生物玻璃/羟丙基甲基纤维素/明胶复合支架的骨再生潜能研究
Sezgi İyigün,Alper Güven,Caner Arslan et al.
Sezgi İyigün et al.
In this study, a novel HPMC/gelatin composite scaffold was prepared by incorporating 13-93B3 borate bioactive glass (BBG) microparticles and cerium oxide (CeO₂) submicrometric particles as a discrete phase, enabling higher ceria loadings w...
Wenhan Ma,Xuqin Tang,Yutong Han et al.
Wenhan Ma et al.
Recurrent aphthous ulcers (RAU) is a common idiopathic oral mucosal disorder marked by painful, round ulcers on non-keratinized tissues such as the buccal, labial, and lingual mucosa. These recurrent lesions impair oral function and quality...
Tumor cell membrane modified clinical lCG nanoprobes for NIR fluorescence imaging of targeted triple negative breast cancer [0.03%]
用于近红外荧光成像的肿瘤细胞膜修饰的临床lCG纳米探针靶向三阴性乳腺癌
Yuxiang Gao,Siyu Huang,Jiaxing Li et al.
Yuxiang Gao et al.
Triple-negative breast cancer (TNBC) is one of the most aggressive breast cancer subtype with high metastatic and recurrence rates. However there is still a lack of effective targeting nanoprobes (NPs) which is leading to suboptimal targete...
Decellularized matrix of porcine skeletal muscle (dECM-pSM) and its in vitro biocompatibility as a graft approach for oral mucosa regeneration [0.03%]
脱细胞猪骨骼肌基质及其体外生物相容性作为口腔黏膜再生的移植方法研究
Jimena Macouzet-Garduño,Iriczalli Cruz-Maya,Janeth Serrano-Bello et al.
Jimena Macouzet-Garduño et al.
Oral mucosa regeneration represents a significant clinical challenge due to the limited availability of autologous grafts and associated morbidity. This study focused on developing and characterizing decellularized matrices (dECM-pSM) for t...
A tunable, biofabricated light-delivery platform for in vitro modelling of age-related macular degeneration using iPSC-derived RPE cells [0.03%]
一种可调的生物制造光输送平台 使用由诱导多能干细胞衍生的视网膜色素上皮细胞 用于模拟年龄相关性黄斑变性的体外模型
Anwar Azad Palakkan,Gowthami Shankar,T P Vignesh et al.
Anwar Azad Palakkan et al.
The lack of physiologically relevant and controllable experimental systems has limited mechanistic understanding of age-related macular degeneration (AMD) and the development of effective therapeutic strategies. Here, we present a tunable i...
A CREKA-modified multifunctional nanoplatform for targeted thrombolysis: an in vitro characterization of efficacy and biocompatibility for retinal thrombotic diseases [0.03%]
一种用于视网膜血栓病的CREKA修饰多功能纳米平台的体内疗效和生物相容性特征研究
Yanmei Wang,Shuxian Shao,Yufan Zhang et al.
Yanmei Wang et al.
Retinal thrombotic diseases, a major cause of vision impairment, lack effective treatments that directly resolve vascular occlusion. To address this challenge, we developed a novel multifunctional nanoplatform for targeted thrombolysis: PLG...
Application of hybrid exosomes-mediated targeted delivery system for sinomenine hydrochloride in rheumatoid arthritis therapy [0.03%]
氯化丝氨菌素治疗类风湿性关节炎的杂合外泌体介导靶向递送系统应用研究
Ziwei Feng,Yue Zhang,Liang Yao et al.
Ziwei Feng et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and joint destruction, whose pathogenesis is closely associated with dysregulated macrophage polarization. Recent evidence highlights the inher...
Extracellular matrix-targeted biomaterials and nanocarriers for pelvic-floor repair/regeneration in stress urinary incontinence: local modulation of the MMP/TIMP axis and NF-κB/MAPK-linked remodeling programs [0.03%]
用于压力性尿失禁盆底修复/再生的细胞外基质靶向生物材料和纳米载体：局部调节MMP/TIMP轴和NF-κB / MAPK相关重塑程序
Caizhi Lin,Yan Ke
Caizhi Lin
Stress urinary incontinence (SUI) is associated with pelvic-floor extracellular-matrix (ECM) remodeling, including an imbalance between matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) that can weaken per...
In vitro cytocompatibility, antibacterial properties, and hemocompatibility of MAO-Zn/PLA composite films for potential guided bone regeneration treatments [0.03%]
用于指导骨再生治疗的MAO-Zn/PLA复合膜的体外细胞相容性、抗菌性能和血液相容性
Hong Cai,Shijie Liu,HaiTao Zhao et al.
Hong Cai et al.
To evaluate the application potential of micro-arc oxidized Zn foil (MAO-Zn)/Poly(lactic acid) (PLA) composite films in guiding oral bone regeneration (GBR) from the perspective of material composition, their cytocompatibility, antibacteria...