Youngsoon Kim,Jie Hao,Yadu Gautam et al.
Youngsoon Kim et al.
Identification of differential gene regulators with significant changes under disparate conditions is essential to understand complex biological mechanism in a disease. Differential Network Analysis (DiNA) examines different biological proc...
Integration of multi-omics data for integrative gene regulatory network inference [0.03%]
多组学数据整合的集成基因调控网络推断方法研究
Neda Zarayeneh,Euiseong Ko,Jung Hun Oh et al.
Neda Zarayeneh et al.
Gene regulatory networks provide comprehensive insights and indepth understanding of complex biological processes. The molecular interactions of gene regulatory networks are inferred from a single type of genomic data, e.g., gene expression...
Jingshan Huang,Karen Eilbeck,Barry Smith et al.
Jingshan Huang et al.
Identification of non-coding RNAs (ncRNAs) has been significantly improved over the past decade. On the other hand, semantic annotation of ncRNA data is facing critical challenges due to the lack of a comprehensive ontology to serve as comm...
Learning multiple distributed prototypes of semantic categories for named entity recognition [0.03%]
用于命名实体识别的语义类分布式原型学习方法研究
Aron Henriksson
Aron Henriksson
The scarcity of large labelled datasets comprising clinical text that can be exploited within the paradigm of supervised machine learning creates barriers for the secondary use of data from electronic health records. It is therefore importa...
Weighted fusion regularisation and predicting microbial interactions with vector autoregressive model [0.03%]
加权融合正则化和用向量自回归模型预测微生物互作
Yan Wang,Tingting He,Xingpeng Jiang et al.
Yan Wang et al.
In this paper, we develop a novel regularisation method for MVAR via weighted fusion which considers the correlation among variables. In theory, we discuss the grouping effect of weighted fusion regularisation for linear models. By virtue o...
Application of consensus string matching in the diagnosis of allelic heterogeneity involving transposition mutation [0.03%]
共有序列匹配在转座突变异体多样性诊断中的应用研究
Fatema Tuz Zohora,M Sohel Rahman
Fatema Tuz Zohora
In this paper, an algorithm is proposed that detects the existence of a common ancestor gene sequence for non-overlapping transposition metric given two input DNA sequences. We consider two cases: fixed length transposition and all length t...
Genome-wide discovery of miRNAs using ensembles of machine learning algorithms and logistic regression [0.03%]
基于逻辑回归和机器学习集成算法的基因组范围内的miRNA发现方法
Benjamin Ulfenborg,Karin Klinga-Levan,Björn Olsson
Benjamin Ulfenborg
In silico prediction of novel miRNAs from genomic sequences remains a challenging problem. This study presents a genome-wide miRNA discovery software package called GenoScan and evaluates two hairpin classification methods. These methods, o...
In silico identification and functional annotation of yeast E3 ubiquitin ligase Rsp5 substrates [0.03%]
酵母E3泛素连接酶RSP5底物的鉴定及功能注释研究
Xiaofeng Song,Lizhen Hu,Ping Han et al.
Xiaofeng Song et al.
Rsp5, E3 ligases conserved from yeast to mammals, plays a key role in diverse processes in yeast. However, many of Rsp5 substrates are still unclear. Therefore we proposed an in silico method to recognise new substrates of Rsp5. To investig...
Towards rule-based metabolic databases: a requirement analysis based on KEGG [0.03%]
基于KEGG的规则型代谢数据库的需求分析
Stephan Richter,Ingo Fetzer,Martin Thullner et al.
Stephan Richter et al.
Knowledge of metabolic processes is collected in easily accessable online databases which are increasing rapidly in content and detail. Using these databases for the automatic construction of metabolic network models requires high accuracy ...
A fast Boyer-Moore type pattern matching algorithm for highly similar sequences [0.03%]
一种用于高度相似序列的快速Boyer-Moore模式匹配算法
Nadia Ben Nsira,Thierry Lecroq,Mourad Elloumi
Nadia Ben Nsira
In the last decade, biology and medicine have undergone a fundamental change: next generation sequencing (NGS) technologies have enabled to obtain genomic sequences very quickly and at small costs compared to the traditional Sanger method. ...