Mitochondrial Dysfunction Contributes to Decompensation in a Zebrafish Model of Isoproterenol-Induced Heart Failure [0.03%]
线粒体功能紊乱参与异丙肾上腺素诱导斑马鱼心力衰竭恶化中的作用机制研究
Manuel Vicente,Aaron García-Blázquez,Antonio Martínez-Sielva et al.
Manuel Vicente et al.
Aim: Heart failure is a clinical syndrome where the heart's structural or functional impairment leads to inadequate blood flow to meet the body's metabolic demands. Mitochondrial dysfunction is increasingly recognized as ...
Caloric Restriction Substantially Improves Glucose Regulation in Mice With Hnf1a-Deficient Beta-Cells [0.03%]
热量限制可显著改善因HNF1A缺陷导致胰岛β细胞功能不全小鼠的糖调节
Shayla Sharmine,Thomas Aga Legøy,Lucas Unger et al.
Shayla Sharmine et al.
Aim: HNF1A-MODY, the most prevalent form of monogenic diabetes, displays incomplete penetrance, indicating the involvement of other environmental and genetic factors in the disease etiology. Currently, it is largely unkno...
Estrogen and Estrogen Receptors in Cardioimmunology: Implications in Physiology, Pathophysiology, and Therapeutic Strategies [0.03%]
心血管免疫学中的雌激素与雌激素受体：在生理、病理生理及治疗策略中的意义
Hongjian Hou,Gabriel K Adzika
Hongjian Hou
Estrogen (E2) and estrogen receptors (ERs) play vital roles in conferring cardioprotection by modulating several immunological homeostatic responses in cardiovascular tissues. Over the recent decades, the role of inflammatory responses as a...
Is Predisposition to T2D Impacted by Polymorphisms in Genes Involved in Insulin Signaling and Cellular Bioenergetics? [0.03%]
2型糖尿病易感性是否会受到与胰岛素信号传导和细胞生物能学相关基因多态性的影响？
Benudhara Pati,Martin Jastroch,Naresh Chandra Bal
Benudhara Pati
Background: Type 2 diabetes (T2D) represents a growing global health challenge, with its prevalence and associated metabolic complications rising sharply over the past two decades. Although the pathogenesis of T2D is comp...
Charlotte Wenzel,David Walzik,Tiffany Wences et al.
Charlotte Wenzel et al.
Exploring Desmin as a Potential Modifier in Duchenne Muscular Dystrophy-Associated Cardiomyopathy [0.03%]
探究肌节蛋白在杜氏肌营养不良相关心肌病中的修饰作用
Brice-Emmanuel Guennec,Yeranuhi Hovhannisyan,Gaëlle Revet et al.
Brice-Emmanuel Guennec et al.
Aim: Duchenne muscular dystrophy (DMD), a rare X-linked genetic disorder, is affecting skeletal and cardiac muscles due to the loss of the dystrophin protein. Modifier proteins, whose expression is altered in DMD patients...
Morten B Thomsen
Morten B Thomsen
Many physiological parameters, such as heart rate and blood pressure, display pronounced daily rhythms, with significant differences between day and night levels. The ability to anticipate the 24 h cycle of ambient light confers an adaptive...
Cardiomyocyte-Specific Deletion of Sirtuin 5 Accelerates the Development of Heart Failure Upon Dysregulating Purine Metabolism [0.03%]
心脏特异性删除Sirtuin 5通过扰乱嘌呤代谢加速心力衰竭的发展
Nikole J Byrne,Christoph Koentges,Katharina Pfeil et al.
Nikole J Byrne et al.
Aim: Sirtuin 5 (SIRT5), a mitochondrial NAD+-dependent deacylase, regulates fundamental cellular pathways, including energy substrate metabolism. The current study is designed to better elucidate the role of SIRT5 in the ...
Fentanyl Disrupts Vagal Control of Airway Tone to Induce Transient Obstruction [0.03%]
芬太尼通过干扰迷走神经控制气道张力来诱导短暂性气道梗阻
Riley R Parks,Marissa J Andersen,Mackenna L Hatfield et al.
Riley R Parks et al.
Aim: Opioid-induced respiratory depression (OIRD) is the primary cause of death in opioid overdose, resulting from both suppressed respiratory rhythm and increased airway and thoracic rigidity that compromise ventilation ...
Electrical Remodeling of Pressure Overloaded Rat Heart Is Attenuated if Imposed During Proliferative Cardiac Growth [0.03%]
增生性心脏生长时施加的压力过载大鼠心脏电重构减弱
Eva Nekvindova,Jaroslav Hrdlicka,Almos Boros et al.
Eva Nekvindova et al.
Aim: Left ventricular pressure overload (LVPO) in adults is associated with adverse electrical remodeling, characterized by reduced conduction velocity (CV). However, the progression of LVPO differs when imposed during th...